Publications

 

 

Student Publications (partial list)

| 2014 | 2013 | 2012 | 2011 |
| 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 |
| 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 |


2014 | Top

(01) Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AMS, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, Aparicio S, Eaves CJ, Hirst, M. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell 14(2):253-63. 2014. [PMID 24440600]

(02) Potter KJ, Westwell-Roper CY, Klimek-Abercrombie AM, Warnock GL, Verchere CB. Death and Dysfunction of Transplanted β-Cells: Lessons Learned From Type 2 Diabetes? Diabetes 63(1):12-9. doi: 10.2337/db12-0364. 2014. [PMID 24357689]

2013 | Top

(01) Ali S, Hirschfeld AF, Mayer ML, Fortuno ES 3rd, Corbett N, Kaplan M, Wang S, Schneiderman J, Fjell CD, Yan J, Akhabir L, Aminuddin F, Marr N, Lacaze-Masmonteil T, Hegele RG, Becker A, Chan-Yeung M, Hancock RE, Kollmann TR, Daley D, Sandford AJ, Lavoie PM, Turvey SE. Functional genetic variation in NFKBIA and susceptibility to childhood asthma, bronchiolitis, and bronchopulmonary dysplasia. J Immunol 190(8):3949-58. 2013. [PMID 23487427]

(02) Cheung AM, Nguyen LV, Carles A, Beer P, Miller PH, Knapp DJHF, Dhillon K, Hirst M, Eaves CJ. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.  Blood 122(18):3129-37. 2013. [PMID 24030380]

(03) Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ. The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol 15(8)916-25. 2013. [PMID 23811688]

(04) Copley MR, Eaves CJ. Developmental changes in hematopoietic stem cell properties. Exp Mol Med 2013 Nov 15;45:e55. doi: 10.1038/emm.2013.98. [PMID 24232254]

(05) Crabtree A, Mercer G, Horan R, Grant S, Tan T, Buxton JA. A qualitative study of the perceived effects of blue lights in washrooms on people who use injection drugs. Harm Reduct J. 2013 Oct 8;10(1):22. doi: 10.1186/1477-7517-10-22. [PMID 24099145]

(06) Ma HK, Min C, Neville A, Eva K. How good is good? Students and assessors’ perceptions of qualitative markers of performance. Teach Learn Med 25(1):15-23. 2013. [PMID 23330890]

(07) Makarem M, Kannan N, Nguyen LV, Knapp DJ, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P, Eaves CJ. Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. PLoS Biol. 11(8):e1001630. doi: 10.1371/journal.pbio.1001630. Epub 2013 Aug 13. [PMID 23966837]

(08) Mayer ML, Blohmke CJ, Falsafi R, Fjell CD, Madera L, Turvey SE, Hancock RE. Rescue of dysfunctional autophagy attenuates hyperinflammatory responses from cystic fibrosis cells. J Immunol 190(3):1227-38. 2013. [PMID 23264659]

(09) Mohajerani MH, Chan AW, Mohsenvand M, Ledue J, Liu R, McVea DA, Boyd JD, Wang YT, Reimers M, Murphy TH. Spontaneous cortical activity alternates between motifs defined by regional axonal projections. Nat Neurosci Aug 25. doi: 10.1038/nn.3499. 2013. [Epub ahead of print] [PMID 23974708]

(10) Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff R, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim E, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole genome sequencing. Blood 122(7):1256-65. 2013. [PMID 23699601]

(11) Sabatini PV, Krentz NA, Zarrouki B, Westwell-Roper C, Nian C, Uy RA, Shapiro AM, Poitout V, Lynn FC. Npas4 Is a Novel Activity-Regulated Cytoprotective Factor in Pancreatic β-Cells. Diabetes 62(8):2808-20. 2013. [PMID 23656887]

(12) Sutton LM, Sanders SS, Butland SL, Singaraja RR, Franciosi S, Southwell AL, Doty CN, Schmidt ME, Mui KK, Kovalik V, Young FB, Zhang W, Hayden MR. Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease. Hum Mol Genet 22(3):452-65. 2013. [PMID 23077216]

(13) Westwell-Roper C, Dunne A, Kim ML, Verchere CB, Masters SL. Activating the NLRP3 Inflammasome Using the Amyloidogenic Peptide IAPP. Methods Mol Biol 1040:9-18. 2013. [PMID 23852593]

(14) Westwell-Roper C, Ehses JA. Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes? Diabetologia. 2013 Dec 21. [PMID 24362729]

(15) Westwell-Roper CY, Ehses JA, Verchere CB. Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and beta cell dysfunction. Diabetes. 2013 Nov 12. [PMID 24222351]

(16) Woodsworth DJ, Castellarin M, Holt RA. Sequence analysis of T-cell repertoires in health and disease. Genome Med 5(10):98. 2013. [PMID 24172704]

(17) Xia J, Fjell CD, Mayer ML, Pena OM, Wishart DS, Hancock RE. INMEX–a web-based tool for integrative meta-analysis of expression data. Nucleic Acids Res 41(W1):W63-W70. 2013. [PMID 23766290]

(18) Xia J, Lyle NH, Mayer ML, Pena OM, Hancock RE. INVEX–a web-based tool for integrative visualization of expression data. Bioinformatics 29(24):3232-4. 2013. [PMID 24078684]

2012 | Top

(01) Achtman AH, Pilat S, Law CW, Lynn DJ, Janot L, Mayer ML, Ma S, Kindrachuk J, Finlay BB, Brinkman FS, Smyth GK, Hancock RE, Schofield L. Effective adjunctive therapy by an innate defense regulatory peptide in a preclinical model of severe malaria. Sci Transl Med 4(135):135ra64. 2012. [PMID 22623740]

(02) Astanehe A, Finkbeiner MR, Krzywinski M, Fotovati A, Dhillon J, Berquin IM, Mills GB, Marra MA, Dunn SE. MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition. Oncogene 31(41):4434-46. 2012. [PMID 22249268]

(03) Benz C, Copley MR, Kent DG, Wohrer S, Cortes A, Aghaeepour N, Ma E, Mader H, Rowe K, Day C, Treloar D, Brinkman RR, Eaves CJ. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 10(3):273-83. 2012. [PMID 22385655]

(04) Berkhout, SG. Relational autonomy on the cutting edge. Am J Bioethics 12(7):59-61. 2012.

(05) Blohmke CJ, Mayer ML, Tang AC, Hirschfeld AF, Fjell CD, Sze MA, Falsafi R, Wang S, Hsu K, Chilvers MA, Hogg JC, Hancock RE, Turvey SE. Atypical activation of the unfolded protein response in cystic fibrosis airway cells contributes to p38 MAPK-mediated innate immune responses. J Immunol 189(11):5467-75. 2012. [PMID 23105139]

(06) Copley MR, Beer PA, Eaves CJ. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell 10(6):690-7. 2012. [PMID 22704509]

(07) Eadie BD, Cushman J, Kannangara TS, Fanselow MS, Christie BR. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus 22(2):241-54.2012. [PMID 21049485]

(08) Henry B, Crabtree A, Roth D, Blackman D, Morshed M. Lyme disease: knowledge, beliefs, and practices of physicians in a low-endemic area. Can Fam Physician 58(5):e289-95. 2012. [PMID 22734172]

(09) Kozoriz MG, Grebenyuk J, Andrews G, Forster BB. Evaluating bone marrow oedema patterns in musculoskeletal injury. Br J Sports Med 46(13):946-53. 2012. [PMID 22496099]

(10) Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, Lütjohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function. Diabetes 61(3):659-64. 2012. [PMID 22315310]

(11) Kulasegaram K, Min C, Ames K, Howey E, Neville A, Norman G. The effect of conceptual and contextual familiarity on transfer performance. Adv Health Sci Educ Theory Pract 17(4):489-99. 2012 [PMID 21959956]

(12) McVea DA, Mohajerani MH, Murphy TH. Voltage-sensitive dye imaging reveals dynamic spatiotemporal properties of cortical activity after spontaneous muscle twitches in the newborn rat. J Neurosci 32(32):10982-94. 2012. [PMID 22875932]

(13) Montane J, Klimek-Abercrombie A, Potter KJ, Westwell-Roper C, Bruce Verchere C. Metabolic stress, IAPP and islet amyloid. Diabetes Obes Metab 14 Suppl 3:68-77. 2012. [PMID 22928566]

(14) Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nat Review Cancer 12(2):133-43. 2012. [full text]

(15) Wright AD, Laing AC. The influence of headform orientation and flooring systems on impact dynamics during simulated fall-related head impacts. Med Eng Phys 34(8):1071-8. 2012. [PMID 22172523]

(16) Young FB, Butland SL, Sanders SS, Sutton LM, Hayden MR. Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases. Prog Neurobiol 97(2):220-38. 2012. [PMID 22155432]

(17) Young FB, Franciosi S, Spreeuw A, Deng Y, Sanders S, Tam NC, Huang K, Singaraja RR, Zhang W, Bissada N, Kay C, Hayden MR. Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice. PLoS One 7(5):e36315. 2012. [PMID 22649491]

2011 | Top

(01) Bailey J, Potter KJ, Verchere CB, Edelstein-Keshet L, Coombs D. Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling. Phys Biol 8(6):066009. 2011. [full text]

(02) Buxton JA, Henry B, Crabtree A, Waheed A, Coulthart M. Using qualitative methods to investigate risk perception of Canadian medical laboratory workers in relation to current prion disease infection control policies. J Toxicol Environ Health A. 74(2-4):241-7. 2011. [PMID 21218349]

(03) Grad LI, Guest WC, Yanai A, Pokrishevsky E, O’Neill MA, Gibbs E, Semenchenko V, Yousefi M, Wishart DS, Plotkin SS, Cashman NR. Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proc Natl Acad Sci U S A 27;108(39):16398-403. 2011. [PMID 21930926]

(04) Guest WC, Cashman NR, Plotkin SS. A theory for the anisotropic and inhomogeneous dielectric properties of proteins. Phys Chem Chem Phys 13(13):6286-95. 2011. [PMID 21359369]

(05) Guest WC, Plotkin SS, Cashman NR. Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions. J Toxicol Environ Health A. 74(2-4):154-60. 2011. Review. [PMID 21218344]

(06) Guest WC, Silverman JM, Pokrishevsky E, O’Neill MA, Grad LI, Cashman NR. Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit. J Toxicol Environ Health A. 74(22-24):1433-59. 2011. Review. [PMID 22043906]

(07) Huang K, Sanders SS, Kang R, Carroll JB, Sutton L, Wan J, Singaraja R, Young FB, Liu L, El-Husseini A, Davis NG, Hayden MR. Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14. Hum Mol Genet 20(17):3356-65. 2011. [PMID 21636527]

(08) Kashefian Naieni A, Yaghoobi P, Woodsworth DJ, Nojeh A. Structural deformations and current oscillations in armchair-carbon nanotube cross devices: a theoretical study. J Phys D: Appl Phys 44:085402(1-7). 2011. [full text]

(09) Lecault V, Vaninsberghe M, Sekulovic S, Knapp DJ, Wohrer S, Bowden W, Viel F, McLaughlin T, Jarandehei A, Miller M, Falconnet D, White AK, Kent DG, Copley MR, Taghipour F, Eaves CJ, Humphries RK, Piret JM, Hansen CL. High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nat Methods 8(7):581-6. 2011. [PMID 21602799]

(10) Mayer ML, Sheridan JA, Blohmke CJ, Turvey SE, Hancock RE. The pseudomonas aeruginosa autoinducer 3O-C12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells. PLoS One 6(1):e16246. 2011. [PMID 21305014]

(11) Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, Davis NG, Raymond LA, Hayden MR. Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum Mol Genet 20(20):3899-909. 2011. [PMID 21775500]

(12) Westwell-Roper C, Dai DL, Soukhatcheva G, Potter KJ, van Rooijen N, Ehses JA, Verchere CB. IL-1 Blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 187(5):2755-65. 2011. [PMID 21813778]

2010 | Top

(01) Dhillon J, Astanehe A, Lee C, Fotovati A, Hu K, Dunn SE. The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells. Oncogene 29(47):6294-300. 2010. [PMID 20802512]

(02) Eadie BD, Cushman J, Kannangara TS, Fanselow MS, Christie BR. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus Nov 3. 2010. [PMID 21049485]

(03) Froger N, Orellana JA, Calvo CF, Amigou E, Kozoriz MG, Naus CC, Sáez JC, Giaume C. Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci 45(1):37-46. 2010. [PMID 20684043]

(04) Guest WC, Cashman NR, Plotkin SS. Electrostatics in the stability and misfolding of the prion protein: salt bridges, self energy, and solvation. Biochem Cell Biol 88(2):371-81. 2010. [PMID 20453937]

(05) Heslop CL, Frohlich JJ, Hill JS. Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography. J Am Coll Cardiol 55(11):1102-9. 2010. [PMID 20223364]

(06) Joe AW, Yi L, Natarajan A, Le Grand F, So L, Wang J, Rudnicki MA, Rossi FM. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol 12(2):153-63. 2010. [PMID 20081841]

(07) Kozoriz MG, Bechberger JF, Bechberger GR, Suen MW, Moreno AP, Maass K, Willecke K, Naus CC. The connexin43 C-terminal region mediates neuroprotection during stroke. J Neuropathol Exp Neurol 69(2):196-206. 2010. [PMID 20084014]

(08) Kozoriz MG, Church J, Ozog MA, Naus CC, Krebs C. Temporary sequestration of potassium by mitochondria in astrocytes. J Biol Chem 285(41):31107-19. 2010. [PMID 20667836]

(09) Law JH, Li Y, To K, Wang M, Astanehe A, Lambie K, Dhillon J, Jones SJ, Gleave ME, Eaves CJ, Dunn SE. Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability. PLoS ONE 5(9):e12661. 2010. [PMID 20844753]

(10) Mayer ML, Easton DM, Hancock REW. Chapter 12. Fine tuning host responses in the face of infection: Emerging roles and clinical applications of host defence peptides. In: Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies, 2010. G. Wang (ed). CABI: Oxfordshire, UK. [ISBN: 9781845936570]

(11) Mayer ML, Hancock REW. Cathelicidins link endocrine and immune systems. Cell Host Microb 7(4):257-259. 2010. [PMID 20413092]

(12) Meng F, Abedini A, Plesner A, Middleton CT, Potter KJ, Zanni MT, Verchere CB, Raleigh DP. The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation. J Mol Biol 400(3):555-66. 2010. [PMID 20452363]

(13) Mohajerani MH, McVea DA, Fingas M, Murphy TH. Mirrored bilateral slow-wave cortical activity within local circuits revealed by fast bihemispheric voltage-sensitive dye imaging in anesthetized and awake mice. J Neurosci 30(10):3745-51. 2010. [PMID 20220008]

(14) Nijnik A, Madera L, Ma S, Waldbrook M, Elliott MR, Easton DM, Mayer ML, Mullaly SC, Kindrachuk J, Jenssen H, Hancock RE. Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol 184(5):2539-50. 2010. [PMID 20107187]

(15) Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim T, Giambra V, Krystal G, Takei CJ, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK, Hansen CL. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA. 107(35):15443-8. 2010. [PMID 20702766]

(16) Potter KJ, Abedini A, Marek P, Klimek AM, Butterworth S, Driscoll M, Baker R, Nilsson MR, Warnock GL, Oberholzer J, Bertera S, Trucco M, Korbutt GS, Fraser PE, Raleigh DP, Verchere CB. Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts. Proc Natl Acad Sci 107(9):4305-10. 2010. [PMID 20160085]

(17) Rezai N, Deisher TA, Heine HL, Wang X, Corbel SY, Leung J, Kerjner A, Rossi FM, Podor TJ, McManus BM. Effects of granulocyte-colony stimulating factor on bone marrow-derived progenitor cells in murine cardiac transplantation. Cardiovasc Path 19(1):36-47. 2010. [PMID 19144547]

(18) Sekirov I, Gill N, Jogova M, Tam N, Robertson M, de Llanos R, Li Y, Finlay BB. Salmonella SPI-1-mediated neutrophil recruitment during enteric colitis is associated with reduction and alteration in intestinal microbiota. Gut Microbes 1(1):30-41. 2010. [PMID 21327114]

(19) Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease. Physiol Rev 90(3):859-904. 2010. Review. [PMID 20664075]

(20) To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ, Dunn SE. Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Res 70(7):2840-51. 2010. [PMID 20332234]

(21) Zraika S, Hull RL, Verchere CB, Clark A, Potter KJ, Fraser PE, Raleigh DP, Kahn SE. Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia 53(6):1046-56. 2010. [PMID 20182863]

2009 | Top

(01) Astanehe A, Finkbeiner MR, Hojabrpour P, To K, Fotovati A, Shadeo A, Stratford AL, Lam WL, Berquin IM, Duronio V, Dunn SE. The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1. Oncogene 28(25):2406-18. 2009. [PMID 19430491]

(02) Dahlhaus R, Hines RM, Eadie BD, Kannangara TS, Hines DJ, Brown CE, Christie BR, El-Husseini A. Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus. Hippocampus 2009 May 12. [PMID 19437420]

(03) Donelan JM, McVea DA, Pearson KG. Force regulation of ankle extensor muscle activity in freely walking cats. J Neurophysiol 101(1):360-371. 2009. [PMID 19019974]

(04) Eadie BD, Zhang WN, Boehme F, Gil-Mohapel J, Kainer L, Simpson JM, Christie BR. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiol Dis 36(2):361-73. 2009. [PMID 19666116]

(05) Easton DM, Nijnik A, Mayer ML, Hancock RE. Potential of immunomodulatory host defence peptides as novel anti-infectives. Trends Biotechnol 27(10):582-90. 2009. [PMID 19683819]

(06) Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE. Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene 28(11):1421-31. 2009. [PMID 19151767]

(07) Heslop C, Miller GE, Hill J. Neighbourhood socioeconomics status predicts non-cardiovascular mortality in cardiac patients with access to universal health care. PLoS ONE 4(1):e4120. 2009. [full text]

(08) Hutton MJ, Westwell-Roper C, Soukhatcheva G, Plesner A, Dutz JP, Verchere CB. Islet allograft rejection is independent of toll-like receptor signaling in mice. Transplantation 88(9):1075-80. 2009. [PMID 19898202]

(09) Joe AW, Y Li, Even Y, Vogl AW, Rossi FMV. Depot-specific differences in adipogenic progenitor abundance and their proliferative response to high fat diet. Stem Cells 27(10):2563-70. 2009. [PMID 19658193]

(10) Johnson JD, Ao Z, Ao P, Li H, Dai L, He Z, Tee M, Potter KJ, Klimek AM, Meloche RM, Thompson DM, Verchere CB, Warnock GL. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplant Apr 10. pii: CT-1977. 2009. [PMID 19500470]

(11) Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood 113(25):6342-50. 2009. [PMID 19377048]

(12) Li L, Guest W, Huang A, Plotkin SS, Cashman NR. Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding. Protein Eng Des Sel 22(8):523-9. 2009. [PMID 19602568]

(13) Mayer ML, Phillips CM, Stadnyk AW, Halperin SA, Lee SF. Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumour necrosis factor. Mol Immunol 46(8-9):1883-91. 2009. [PMID 19278729]

(14) Mayer ML, Phillips CM, Townsend RA, Halperin SA, Lee SF. Differential activation of dendritic cells by Toll-like receptor agonists isolated from the Gram-positive vaccine vector Streptococcus gordonii. Scand J Immunol 69(4):351-6. 2009. [PMID 19284500]

(15) McVea DA, Pearson KG. Object avoidance during locomotion. Adv Exp Med Biol. 629: 293-315. 2009. [PMID 19227506]

(16) Parkinson PF, Kannangara TS, Eadie BD, Burgess BL, Wellington CL, Christie BR. Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1. Lipids Health Dis Feb 24 8:5. 2009. [PMID 19239689]

(17) Potter KJ, Scrocchi LA, Warnock GL, Ao Z, Younker MA, Rosenberg L, Lipsett M, Verchere CB, Fraser PE. Amyloid inhibitors enhance survival of cultured human islets. Biochim Biophys Acta. 1790(6):566-74. 2009. [PMID 19264107]

(18) Sekirov I, Finlay BB. The role of the intestinal microbiota in enteric infection. J Physiol 587(Pt 17):4159-67. 2009. [PMID 19491248]

(18) Zarzeczny A, Scott C, Hyun I, Bennett J, Chandler J, Charge S, Heine H, Isasi R, Kazuto K, Lovell-Badge R, McNagny K, Pei D, Rossant J, Surani A, Taylor P, Ogbogu U, Caulfield T. iPS Cells: mapping the policy issues. Cell 139(6):1032-7. 2009. [PMID 20005794]

2008 | Top

(01) Astanehe A, Arenillas D, Wasserman WW, Leung PC, Dunn SE, Davies BR, Mills GB, Auersperg N. Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer. J Cell Sci 121(5):664-74. 2008. [PMID 18270270]

(02) Berkhout SG. Buns in the oven: Objectification, surrogacy, and women’s autonomy. Social Theory and Practice 34:1 2008. [full text]

(03) Brunham LR, Kruit JK, Verchere CB, Hayden MR. Cholesterol in islet dysfunction and type 2 diabetes. J Clin Invest 118(2):403-8. 2008. [PMID 18246189]

(04) Christie BR, Eadie BD, Kannangara TS, Robillard JM, Shin J, Titterness AK. Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus. Neuromolecular Med 10(2):47-58. 2008. [PMID 18535925]

(05) Hu Q, Coburn B, Deng W, Li Y, Shi X, Lan Q, Wang B, Coombes BK, Finlay BB. Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1. J Clin Microbiol 46(4):1330-6. 2008. [PMID 18272702]

(06) Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C. Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway. Clin Cancer Res. 14(7):1926-30. 2009. [PMID 18381929]

(07) Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Can Res 68:8661-6. 2008. [full text]

(08) Meng F, Marek P, Potter KJ, Verchere CB, Raleigh DP. Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death. Biochem 47(22):6016-24. 2008. [PMID 18457428]

(09) Sekirov I, Tam NM, Jogova M, Robertson ML, Li Y, Lupp C, Finlay BB. Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection. Infect Immun 76(10):4726-36. 2008. [PMID 18678663]

(10) Young FB. A life without pain? Hedonists take note. Clin Genet. 73(1):31-3. 2008. [PMID 18070140]

(11) Young FB. When adaptive processes go awry: gain-of-function in SCN9A. Clin Genet 73(1):34-6. 2008. [PMID 18070139]

2007 | Top

(01) Asper DJ, Sekirov I, Finlay BB, Rogan D, Potter AA. Cross reactivity of enterohemorrhagic Escherichia coli O157:H7-specific sera with non-O157 serotypes. Vaccine 25(49):8262-9. 2007. [PMID 17980466]

(02) Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW. Selective up-regulation of LXR-regulated genes ABCA1, ABCG1 and APOE in macrophages through increased endogenous synthesis of 24(S), 25-epoxycholesterol. J Biol Chem 282(8):5207-16. 2007. [PMID 17186944]

(03) Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med 13(3):340-7. 2007. [PMID 17322896]

(04) Coburn B, Grassl GA, Finlay BB. Salmonella, the host and disease: a brief review. Immunol Cell Biol 85(2):112-8. 2007. [PMID 17146467]

(05) Coburn B, Sekirov I, Finlay BB. Type III Secretion Systems and Disease. Clin Microbiol Rev 20(4):535-49. 2007. [PMID 17934073]

(06) Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, Finlay BB. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2(3):204. 2007. [PMID 18030708]

(07) Sly LM, Ho V, Antignano F, Ruschmann J, Hamilton M, Lam V, Rauh MJ, Krystal G. The role of SHIP in macrophages. Front Biosci 12:2836-48. 2007. Review. [PMID 17485263]

(08) Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, Dunn SE. Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy. Breast Cancer Res 9(5):R61. 2007. [PMID 17875215]

(09) Wickham ME, Lupp C, Vazquez A, Mascarenhas M, Coburn B, Coombes BK, Karmali MA, Puente JL, Deng W, Brett Finlay B. Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE. Microbes Infect 9(3):400-7. 2007. [PMID 17317262]

(10) Wu J, Stratford A, Astanehe A, Dunn S. YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression. Trans Oncogen 2007; 2:49-65. [PubMed not available]

2006 | Top

(01) Arikawa E, Cheung C, Sekirov I, Battell ML, Yuen VG, McNeill JH. Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. Can J Physiol Pharmacol 84(8-9):823-33. 2006. [PMID 17111027]

(02) Bertram J, Peacock JW, Tan C, Mui AL, Chung SW, Gleave ME, Dedhar S, Cox ME, Ong CJ. Inhibition of the phosphatidylinositol 3′-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer Res 66(9):4781-8. 2006. [PMID 16651432]

(03) Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. 2006. [PMID 16543947]

(04) Brunham LR, Kruit JK, Pape TD, Parks JS, Kuipers F, Hayden MR. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. 2006. [PMID 16946132]

(05) Brunham LR, Singaraja RR, Hayden MR. Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis. Annu Rev Nutr 26:105-29. 2006. Review. [PMID 16704350]

(06) Christie BR, Li AM, Redila VA, Booth H, Wong BK, Eadie BD, Ernst C, Simpson EM. Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus. Neurosci 137(3):1031-7. 2006. [PMID 16289828]

(07) Coburn B. The first characterization of homozygous HOX gene mutation in humans. Clin Genet 69:205-6. 2006. [full text]

(08) Coburn B. Transglutaminase 5 mutations result in acral peeling skin syndrome. Clin Genet 69:204-5. 2006. [full text]

(09) Dimaras H, Coburn B, Pajovic S, Gallie BL. Loss of p75 neurotrophin receptor expression accompanies malignant progression to human and murine retinoblastoma. Mol Carcinog 45(5):333-43. 2006. [PMID 16555252]

(10) Kozoriz MG, Bates DC, Bond SR, Lai CP, Moniz DM. Passing potassium with and without gap junctions. J Neurosci 26(31):8023-4. 2006. [PMID 16888836]

(11) Kozoriz MG, Kuzmiski JB, Hirasawa M, Pittman QJ. Galanin modulates neuronal and synaptic properties in the rat supraoptic nucleus in a use and state dependent manner. J Neurophysiol 96(1):154-64. 2006. [PMID 16611841]

(12) Langlois S, Yong PJ, Yong SL, Barrett I, Kalousek DK, Miny P, Exeler R, Morris K, Robinson WP. Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism. Prenat Diagn 26(6):548-58. 2006. [PMID 16683298]

(13) Noubir S, Lee JS, Reiner NE. Pleiotropic effects of phosphatidylinositol 3-kinase in monocyte cell regulation. Prog Nucleic Acid Res Mol Biol 81:51-95. 2006. [PMID 16891169]

(14) Olson AK, Eadie BD, Ernst C, Christie BR. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 16(3):250-60. 2006. [PMID 16411242]

(15) Poburko D, Potter K, van Breemen E, Fameli N, Liao CH, Basset O, Ruegg UT, van Breemen C. Cell Calcium 40(4):359-71. 2006. [PMID 16806462]

(16) Sekirov I, Finlay BB. Human and microbe: united we stand. Nat Med 12(7):736-7. 2006. [PMID 168829917]

(17) Shih AY, Fernandes HB, Choi FY, Kozoriz MG, Liu Y, Li P, Cowan CM, Klegeris A. Policing the police: astrocytes modulate microglial activation. J Neurosci 26(15):3887-8. 2006. [PMID 16611803]

(18) Singaraja RR, Van Eck M, Bissada N, Zimetti F, Collins HL, Hildebrand RB, Hayden A, Brunham LR, Kang MH, Fruchart JC, Van Berkel TJ, Parks JS, Staels B, Rothblat GH, Fievet C, Hayden MR. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circ 114(12):1301-9. 2006. [PMID 16940190]

(19) Singaraja RR, Visscher H, James ER, Chroni A, Coutinho JM, Brunham LR, Kang MH, Zannis VI, Chimini G, Hayden MR. Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro. Circ Res 99(4):389-97. 2006. [PMID 16873719]

(20) Wickham ME, Lupp C, Mascarenhas M, Vazquez A, Coombes BK, Brown NF, Coburn BA, Deng W, Puente JL, Karmali MA, Finlay BB. Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection. J Infect Dis 194(6):819-27. 2006. [PMID 16941350]

(21) Yong PJ, Langlois S, Dadelszen P, Robinson W. The association between preeclampsia and placental trisomy 16 mosaicism. Prenat Diagn 26(10):956-61. 2006. [PMID 16874829]

2005 | Top

(01) Brown NF, Vallance BA, Coombes BK, Valdez Y, Coburn BA, Finlay BB. Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine. PLoS Pathog (3):32. 2005. [PMID 16304611]

(02) Brunham L. A common mutation in IVD associated with asymptomatic isovaleric acidemia: implications for newborn screening. Clin Genet 67:226-7. 2005. [full text]

(03) Brunham L. Common inactivating mutations in PCSK9 cause low LDL cholesterol. Clin Genet 67:476-7. 2005. [full text]

(04) Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. PLoS Genet 1(6):0739-47. [PMID 16429166]

(05) Coburn B. Osteoarthritis? Try asporin. Clin Genet 67(5):394-5. 2005. [PMID 15811005]

(06) Coburn B. Beating congenital heart defects with embryonic stem cells. Clin Genet 67(3):224-5. 2005. [full text]

(07) Coburn B, Li Y, Owen D, Vallance BA, Finlay BB. Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis. Infect Immun 73(6):3219-27. 2005. [PMID 15908346]

(08) Coombes BK, Coburn B, Potter AA, Gomis S, Mirakhur K, Li Y, Finlay BB. Analysis of the contribution of salmonella pathogenicity island 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis. Infect Immun 73:7181-9. 2005. [PMID 16239510]

(09) Eadie BD, Redila Va, Christie BR. Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. J Comp Neurol 486(1):39-47. 2005. [PMID 15834963]

(10) Heine HL, Leong HS, Rossi FM, McManus BM, Podor TJ. Strategies of conditional gene expression in myocardium: an overview. Methods Mol Med 112:109-54. 2005. [PMID 16010014]

(11) Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Lam V, Huxham L. SHIP represses the generation of alternatively activated macrophages. Immunity 23(4):361074. 2005. [PMID 16226502]

(12) Sendide K, Reiner NE, Lee JS, Bourgoin S, Talal A, Hmama Z. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1. J Immunol 174(7):4210-9. 2005. [PMID 15778383]

(13) Timmins JM, Lee JY, Boudyguina E, Kluckman KD, Brunham LR, Mulya A, Gebre AK, Coutinho JM, Colvin PL, Smith TL, Hayden MR, Maeda N, Parks JS. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 115(5):1333-1342. 2005. [PMID 15841208]

2004 | Top

(01) Brunham LR. The long and short of it: C-type naturietic peptide as a novel therapy for achondroplasia? Clin Genet 65(6):458-9. 2004. [full text]

(02) Brunham LR. MEF2A at the heart of coronary artery disease? Clin Genet 65(3):178-80. 2004. [full text]

(03) Coburn B. A rare disorder, ethylmalonic encephalopathy, is caused by mutations in a mitochondrial protein. Clin Genet 65(6):460-2. 2004. [full text]

(04) Coburn, BA. Pyruvate kinase deficiency: providing protection from Plasmodium parasitism. Clin Genet 65(4):264-6. 2004. [full text]

(05) Davani EY, Dorscheid DR, Lee CH, van Breemen C, Walley KR. Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton. Am J Physiol Heart Circ Physiol 287(3):H1013-22. 2004. [PMID 15087287]

(06) Gruenheid S, Sekirov I, Thomas NA, Deng W, O’Donnell P, Goode D, Li Y, Frey EA, Brown NF, Metainikov P, Pawson T, Ashman K, Finlay BB. Identification and characterization of N1eA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbio 51(5):1233-49. 2004. [PMID 14982621]

(07) Guan JZ, Tamasawa N, Brunham LR, Matsui J, Murakami H, Suda T, Ochiai S, Tsutsui M, Kudou K, Satoh K, Hayden MR. A case of Tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1. Am J Med Genet 130A(4):398-401. 2004. [PMID 15384103]

(08) Hung RW, Chow AW. Dissecting the “end game”: clinical relevance, molecular mechanisms and laboratory assessment of apoptosis. Clin Invest Med 27(6):324-44. 2004. [PMID 15675113]

(09) Johnson RM, Heslop CL, Deber CM. Hydrophobic helical hairpins: design and packing interactions in membrane environments. Biochem 43(45):14361-9. 2004. [PMID 15533040]

(10) Lee JSI, Hmama Z, Mui A, Reiner NE. Stable gene silencing in human monocytic cell lines using lentiviral-delivered siRNA: silencing of the p110a isoform of phosophoinositide 3-kinase reveals differential regulation of adherence induced by 1a, 25-dihydroxycholecalciferol and bacterial lipopolysaccharide. J Biol Chem 279:9379-88. 2004. [PMID 14672955]

(11) McHardy LM, Sinotte R, Troussard A, Sheldon C, Church J, Williams DE, Andersen RJ, Dedhar S, Roberge M, Roskelley CD. The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. Cancer Res 64(4):1468-74. 2004. [PMID 14973060]

(12) Poburko D, Kuo KH, Dai J, Lee CH, van Breemen C. Organellar junctions promote targeted Ca2+ signaling in smooth muscle: why two membranes are better than one. Trends Pharmacol Sci 25(1):8-15. 2004. [PMID 14723973]

(13) Poburko D, Lee CH, van Breemen C. Vascular smooth muscle mitochondria at the cross roads of Ca(2+) regulation. Cell Calcium 35(6):509-21. 2004. [PMID 15110141]

(14) Rauh MJ, Ho V, Krystal G. SHIP is a negative regulator of M2 (alternative) macrophage programming: implications for cancer and chronic inflammation. Clin Invest Med 27(4):220-1. 2004.

(15) Rauh MJ, Sly LM, Kalesnikoff J, Hughes MR, Cao LP, Lam V, Krystal G. The role of SHIP1 in macrophage programming and activation. Biochem Soc Trans 32(5):785-8. 2004. [PMID 15494015]

(16) Sheldon C, Cheng YM, Church J. Concurrent measurements of the free cytosolic concentrations of H+ and Na+ ions with fluorescent indicators. Pflugers Arch 449(3):307-18. 2004. [PMID 15452716]

(17) Sheldon C, Church J. Reduced contribution from Na+/H+ exchange to acid extrusion during anoxia in adult rat hippocampal CA1 neurons. J Neurochem 88(3):594-603. 2004. [PMID 14720209]

(18) Sheldon C, Diarra A, Cheng YM, Church J. Sodium influx pathways during and after anoxia in rat hippocampal neurons. J Neurosci 24(49):11057-69. 2004. [PMID 15590922]

(19) Sly LM, Omeis SL, Rauh MJ, Krystal G. SHIP is essential for both endotoxin- and CpG-induced tolerance and for their cross-tolerance. Blood 104(11):3340.

(20) Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21(2):227-39. 2004. [PMID 15308103]

(21) Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 5:79-90. 2004. [PMID 14749128]

(22) Zaharik ML, Cullen VL, Fung AM, Libby SJ, Kujat Choy SL, Coburn B, Kehres DG, Maguire ME, Fang FC, Finlay BB. The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model. Infect Immun 72(9):5522-5. 2004. [PMID 15322058]

2003 | Top

(01) Brunham, LR, Hayden MR. Clarity is essential when using nucleotide number systems. Atherosclerosis 170(2):349. 2003. [PMID 14612218]

(02) Brunham, L, Lee P, Pinto A. Medical students not mum on Iraq. CMAJ. 169(6):541. 2003. [full text]

(03) Kalesnikoff J, Sly LM, Hughes MR, Buchse T, Rauh MJ, Cao LP et al. The role of SHIP in cytokine-induced signaling. Rev Physiol Biochem Pharmacol 149:87-103. 2003. [PMID 12692707]

(04) Krebs C, Fernandes HB, Sheldon C, Raymond LA, Baimbridge KG. Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. J Neurosci 23:3364-72. 2003. [PMID 12716944]

(05) Kuo KH, Dai J, Seow CY, Lee CH, van Breemen C. Relationship between asynchronous Ca2+ waves and force development in intact smooth muscle bundles of the porcine trachea. Am J Physiol Lung Cell Mol Physiol 285(6):L1345-53. 2003. [PMID 12936908]

(06) Rauh MJ, Kalesnikoff J, Hughes M, Sly L, Lam V, Krystal G. Role of Src homology 2-containing-inositol 5′-phosphatase (SHIP) in mast cells and macrophages. Biochem Soc Trans 31:286-91. 2003. [PMID 12546703]

(07) Rupert JL, Monsalve MV, Kidd KK, Tan C, Hochachka PW, Devine DV. Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians 17. Ann Hum Genet 67:426-32. 2003. [PMID 12940916]

(08) Singaraja RR, Brunham LR, Visscher H, Kastelein JJ, Hayden MR. Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. Arterioscler Thromb Vasc Biol 23:1322-32. 2003. [PMID 12763760]

(09) Sly LM, Rauh MJ, Kalesnikoff J, Buchse T, Krystal G. SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp Hematol 31(12):1170-81. 2003. [PMID 14662322]

(10) Szado T, Kuo KH, Bernard-Helary K, Poburko D, Lee CH, Seow C, Ruegg UT, van Breemen C. Agonist-induced mitochondrial Ca2+ transients in smooth muscle. FASEB J 17:28-37. 2003. [PMID 12522109]

(11) Wellington CL, Brunham LR, Zhou S, Singaraja RR, Visscher H, Gelfer A et al. Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J Lipid Res 44:1470-80. 2003. [PMID 12730295]

(12) Yong PJ. Placentology in the world’s most livable city: HLA-G, pre-eclampsia and HIF-11. Clin Invest Med 26:10-11. 2003.

(13) Yong PJ, Barrett IJ, Kalousek DK, Robinson WP. Clinical aspects, prenatal diagnosis, and pathogenesis of trisomy 16 mosaicism. J Med Genet 40:175-82. 2003. [PMID 12624135]

(14) Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee KF, Gage FH. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci USA 100(11):6777-82. 2003. [PMID 12748381]

2002 | Top

(01) Brett CL, Kelly T, Sheldon C, Church J. Regulation of Cl-/HCO3- exchange by cMP-dependent protein kinase in actuely isolated adult rata hippocampal CA1 neurons. J Physiol 545:837-53. 2002. [PMID 12482890]

(02) Crowley CM, Lee CH, Gin SA, Keep AM, Cook RC, van Breemen C. The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein. Am J Physiol Heart Circ Physiol 283:H1271-81. 2002. [PMID 12234776]

(03) Kum WW, Hung RW, Cameron SB, Chow AW. Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. J Infect Dis 185:555-60. 2002. [PMID 11865410]

(04) Lee CH, Rahimian R, Szado T, Sandhu J, Poburko D, Behra T, Chan L, van Breemen C. Sequential opening of IP(3)-sensitive Ca(2+) channels and SOC during alpha-adrenergic activation of rabbit vena cava. Am J Physiol Heart Circ Physiol 282:H1768-77. 2002. [PMID 11959642]

(05) Lee CH, Poburko D, Kuo KH, Seow CY, van Breemen C. Ca(2+) oscillations, gradients, and homeostasis in vascular smooth muscle. Am J Physiol Heart Circ Physiol 282:H1571-83. 2002. [PMID 11959618]

(06) Lee CH, Poburko D, Kuo KH, Seow C, van Breemen C. Relationship between the sarcoplasmic reticulum and the plasma membrane. Novartis Found Symp 246:26-41. 2002. [PMID 12164314]

(07) Otto SP, Yong PJ. The evolution of gene duplicates. Adv Genet 46:451-83. 2002. [PMID 11931235]

(08) Rauh MJ. The forecast is bright for budding clinician-scientists on Canada’s west coast. Clin Invest Med 25:66-7. 2002.

(09) Rauh MJ, Krystal G. Of mice and men: elucidating the role of SH2-containing inositol 5-phosphatase (SHIP) in human disease. Clin Invest Med 25:68-70. 2002.

(10) Rauh MJ. An inspiring model for translational research: nuclear factor-kappaB (NF-kappaB), bench to bedside. Clin Invest Med 25:65-6. 2002.

(11) Sheldon C, Church J. Na+/H+ exchange: molecular regulation to therapeutic development. Clin Invest Med 25:229-32. 2002.

(12) Sheldon C, Church J. Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons. J Neurophysiol 87:2209-24. 2002. [PMID 11976362]

(13) Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med 8:943-9. 2002. [PMID 12161749]

(14) Tan C, Mui A, Dedhar S. Integrin-linked kinase regulates inducible nitric oxide synthase and cylcooxygenase-2 expression in an NF-kappa B-dependent manner. J Biol Chem 277:3109-16. 2002. [PMID 11724787]

(15) Yong PJ, Marion SA, Barrett IJ, Kalousek DK, Robinson WP. Evidence for imprinting on chromosome 16: the effect of uniparental disomy on the outcome of mosaic trisomy 16 pregnancies. Am J Med Genet 112:123-32. 2002. [PMID 12244544]

2001 | Top

(01) Coburn B Two new genes have been identified for the obesity disorder Bardet-Biedl syndrome. Clin Genet 60:176-7. 2001. [PMID 11595018]

(02) Diarra A, Sheldon C, Church J. In situ calibration and [H+] sensitivity of the fluorescent Na+ indicator SBFI. Am J Physiol Cell Physiol 280:C1623-3. 2001. [PMID 11350758]

(03) Kum WW, Cameron SB, Hung RW, Kalyan S, Chow AW. Temporal sequence and kinetics of proinflammatory and anti-inflammatory cytokine secretion induced by toxic shock syndrome toxin 1 in human peripheral blood mononuclear cells. Infect Immun 69:7544-9. 2001. [PMID 11705931]

(04) Lee CH, Poburko D, Sahota P, Sandhu J, Ruehlmann DO, van Breemen C. The mechanism of phenylephrine-mediated [Ca(2+)](i) oscillations underlying tonic contraction in the rabbit inferior vena cava. J Physiol 534:641-50. 2001. [PMID 11483697]

2000 | Top

(01) Ruehlmann DO, Lee CH, Poburko D, van Breemen C. Asynchronous Ca(2+) waves in intact venous smooth muscle. Circ Res 86:E72-9. 2000. [PMID 10700457]

(02) Wright JM, Lee CH, Chambers GK. Real-world effectiveness of anti-hypertensive drugs. (Letter to the editor). CMAJ 162: 190-1. 2000.

1999 | Top

(01) Bernard NF, Yannakis CM, Lee JS, Tsoukas CM. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. J Infect Dis 179:538-47. 1999. [PMID 9952359]

(02) Diarra A, Sheldon C, Brett CL, Baimbridge KG, Church J. Anoxia-evoked intracellular pH and Ca2+ concentration changes in cultured postnatal rat hippocampal neurons. Neuroscience 93: 1003-16. 1999. [PMID 10473265]

(03) Rauh MJ, Blackmore V, Andrechek ER, Tortorice CG, Daly R, Lai VK et al. Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein. Mol Cell Biol 19: 8169-79. 1999. [PMID 10567542]

(04) Wright JM, Lee CH, Chambers GK. Systematic review of anti-hypertensive therapies: does the evidence assist in choosing a first-line drug? CMAJ 161: 22-35. 1999. [PMID 10420860]

(05) Wright JM, Lee CH, Chambers GK. Choosing a first-line anti-hypertensive. (Letter to the editor). CMAJ 161: 1101. 1999.

1998 | Top

(01) Tang P, Sutherland CL, Gold MR, Finlay BB. Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway. Infect Immun 66(3):1106-12. 1998. [PMID 9488402]

(02) Webster MA, Hutchinson JN, Rauh MJ, Muthuswamy SK, Anton M, Tortorice CG et al. Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol 18: 2344-59. 1998. [PMID 9528804]

1997 | Top

(01) Appanna VD, Rauh MJ, Hamel R, Gauthier E. Isolation and characterization of an aluminum sensitive mutant of Pseudomonas fluorescens. FEMS Microbiol Letts. 1997.

(02) Hung RW, Chow AW. Apoptosis – molecular mechanisms, regulation, and role in pathogenesis. Can J Infect Dis. 1997.

1996 | Top

(01) Richter AM, Yip S, Meadows H, Jain AK, Neyndorff H, Moreno G, Salet C, Levy JG. Photosensitizing potencies of the structural analogues of benzoporphyrin derivative in different biological test systems. J Clin Laser Med Surg 14(5):335-41. 1996. [PMID 9612201]

(02) Tang P, Rosenshine I, Cossart P, Finlay BB. Listeriolysin O activates mitogen-activated protein kinase in eucaryotic cells. Infect Immun 64:2359-61. 1996. [PMID 8675352]

1995 | Top

(01) Levy JG, Dowding C, Mitchell D, Sorrenti R, Yip S, Jamieson C. Selective elimination of malignant stem cells using photosensitizers followed by light treatment. Stem Cells 13(4):336-43. 1995. [PMID 7549891]

1994 | Top

(01) Tang P, Rosenshine I, Finlay BB. Listeria monocytogenes, an invasive bacterium, stimulates MAP kinase upon attachment to epithelial cells. Mol Biol Cell 5:455-64. 1994. [PMID 8054686]

1993 | Top

(01) Leitch HA, Yip ST, Jamieson CH, Levy JG. Inhibition of murine hematopoiesis by CAMAL, an inhibitor of human hematopoiesis. Leukemia 7:717-24. 1993. [PMID 8483324]

(02) Mohamedali Z, Auersperg N. A simple method to produce quantifiable cell suspensions from fixed, stained monolayers grown in culture. In Vitro Cell Dev 29A:685-7. 1993.

(03) Mohamedali Z, Auersperg N. Immortalization reduces the capacity of normal cells to inhibit the transformation of their Ha-ras-oncogene infected neighbors in coculture. Am Assoc Can Res 34:177. 1993.

(04) Mohamedali Z, Auersperg N. Quantifiable cell suspensions from fixed, stained monolayers grown in culture. In Vitro Cell Dev Biol Anim 29A(9):685-7. 1993. [PMID 7691790]

(05) Tang P, Foubister V, Pucciarella MG, Finlay BB. Methods to study bacterial invasion. J Micro Methods 18(3): 227-40. 1993.

1992 | Top

(01) Mohamedali Z, Auersperg N. Inhibition of early transformation events by low passage cells exceeds inhibition by immortalized cells. Proc Can Fed Biol Soc 35:69. 1992.

1991 | Top

(01) Richter AM, Yip S, Waterfield E, Logan PM, Slonecker CE, Levy JG. Mouse skin photosensitization with benzoporphyrin derivatives and Photofrin: macroscopic and microscopic evaluation. Photochem Photobiol 53:281-6. 1991. [PMID 1826372]

(02) Mohamedali Z, Auersperg N. Cell interactions in the regulation of transformation. In Vitro Cell Dev 27:130A. 1991.