Student Publications(partial list)

| 2021 |
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2021 | Top

(01) Alford MA, Baquir B, An AY, Choi K-YG, Hancock REW. NtrBC selectively regulates host-pathogen interactions, virulence, and ciprofloxacin susceptibility of Pseudomonas aeruginosa. Frontiers in Cellular and Infection Microbiology, 2021. [full text]

(02) An AY, Choi KG, Baghela AS, Hancock REW. An overview of biological and computational methods for designing mechanism-informed anti-biofilm agents. Front Microbiol. 2021 Apr 13;12:640787. doi: 10.3389/fmicb.2021.640787. eCollection 2021. [PMID: 33927701]

(03) Bonizzato M, James ND, Pidpruzhnykova G, Pavlova N, Shkorbatova P, Baud L, Martinez-Gonzalez C, Squair JW, DiGiovanna J, Barraud Q, Micera S, Courtine G. Multi-pronged neuromodulation intervention engages the residual motor circuitry to facilitate walking in a rat model of spinal cord injury. Nat Commun. 2021 Mar 26;12(1):1925. doi: 10.1038/s41467-021-22137-9. [PMID: 33771986]

(04) Boutin RC, Petersen C, Woodward SE, Serapio-Palacios A, Bozorgmehr T, Loo R, Chalanuchpong A, Cirstea M, Lo B, Huus KE, Barcik W, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Subbarao P, McNagny KM, Turvey SE, Finlay BB. Bacterial-fungal interactions in the neonatal gut influence asthma outcomes later in life. Elife. 2021 Apr 20;10:e67740. doi: 10.7554/eLife.67740. [PMID: 33876729]

(05) Boutin RCT, Sbihi H, McLaughlin RJ, Hahn AS, Konwar KM, Loo RS, Dai D, Petersen C, Brinkman FSL, Winsor GL, Sears MR, Moraes TJ, Becker AB, Azad MB, Mandhane PJ, Subbarao P, Turvey SE, Finlay BB. Composition and associations of the infant gut fungal microbiota with environmental factors and childhood allergic outcomes. mBio. 2021 Jun 1:e0339620. doi: 10.1128/mBio.03396-20. Online ahead of print. [PMID: 34060330]

(06) Cirstea MS, Sundvick K, Golz E, Yu AC, Boutin RCT, Kliger D, Finlay BB, Appel-Cresswell S. The gut mycobiome in Parkinson’s disease. J Parkinsons Dis. 2021;11(1):153-158. doi: 10.3233/JPD-202237. [PMID: 33164944]

(07) Dubland JA, Allahverdian S, Besler KJ, Ortega C, Wang Y, Pryma CS, Boukais K, Chan T, Seidman MA, Francis GA. Low LAL (Lysosomal Acid Lipase) expression by smooth Muscle cells relative to macrophages as a mechanism for arterial foam cell formation. Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):e354-e368. doi: 10.1161/ATVBAHA.120.316063. Epub 2021 Apr 1. [PMID: 33792344]

(08) Finneran P, Pampana A, Khetarpal SA, Trinder M, Patel AP, Paruchuri K, Aragam K, Peloso GM, Natarajan P. Lipoprotein(a) and coronary artery disease risk without a family history of heart disease. J Am Heart Assoc. 2021 Feb;10(5):e017470. doi: 10.1161/JAHA.120.017470. Epub 2021 Feb 26. [PMID: 33631942]

(09) Harman KA, DeVeau KM, Squair JW, West CR, Krassioukov AV, Magnuson DSK. Effects of early exercise training on the severity of autonomic dysreflexia following incomplete spinal cord injury in rodents.Physiol Rep. 2021 Aug;9(15):e14969. doi: 10.14814/phy2.14969. [PMID: 34337884]

(10) Kwon D, Lozada J, Zhang Z, Zeisler J, Poon R, Zhang C, Roxin Á, Lin KS, Perrin D, Benard F. High-contrast CXCR4-targeted18 F-PET imaging using a potent and selective antagonist. Mol Pharm. 2021 Jan 4;18(1):187-197. doi: 10.1021/acs.molpharmaceut.0c00785. Epub 2020 Nov 30. [PMID: 33253591]

(11) Li EW, Lee A, Vaseghi-Shanjani M, Anagnostopoulos A, Jagelaviciute G, Kum E, Petraszko T, Elmoazzen H, Allan D, Fingrut W. Multimedia resources to support the recruitment of committed hematopoietic stem cell donors: Perspectives of the most-needed donors. Transfusion. 2021 Jan;61(1):274-285. doi: 10.1111/trf.16186. Epub 2020 Dec 2. [PMID: 33269472]

(12) Lisonkova S, Bone JN, Muraca GM, Razaz N, Wang LQ, Sabr Y, Boutin A, Mayer C, Joseph KS. Incidence and risk factors for severe preeclampsia, hemolysis, elevated liver enzymes, and low platelet count syndrome, and eclampsia at preterm and term gestation: a population-based study. Am J Obstet Gynecol. 2021 May 8:S0002-9378(21)00549-4. doi: 10.1016/j.ajog.2021.04.261. Online ahead of print. [PMID: 33974902]

(13) Lucci VM, Harrison EL, DeVeau KM, Harman KA, Squair JW, Krassioukov A, Magnuson DSK, West CR, Claydon VE. Markers of susceptibility to cardiac arrhythmia in experimental spinal cord injury and the impact of sympathetic stimulation and exercise training. Auton Neurosci. 2021 Aug 10;235:102867. doi: 10.1016/j.autneu.2021.102867. Online ahead of print. [PMID: 34399294]

(14) Mannar D, Leopold K, Subramaniam S. Glycan reactive anti-HIV-1 antibodies bind the SARS-CoV-2 spike protein but do not block viral entry. Sci Rep. 2021 Jun 14;11(1):12448. doi: 10.1038/s41598-021-91746-7. [PMID: 34127709]

(15) Marchand M, Chen V, Trinder M, Cermakova L, Brunham LR. Patient perspectives regarding genetic testing for familial hypercholesterolemia. CJC Open. 2021 Apr 8;3(5):557-564. doi: 10.1016/j.cjco.2020.12.006. eCollection 2021 May. [PMID: 34027362]

(16) Montgomery A, Tam F, Gursche C, Cheneval C, Besler K, Enns W, Manku S, Rey K, Hanson PJ, Rose-John S, McManus BM, Choy JC. Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells. Am J Physiol Cell Physiol. 2021 Apr 1;320(4):C554-C565. doi: 10.1152/ajpcell.00323.2020. Epub 2021 Jan 20. [PMID: 33471622]

(17) Moulson AJ, Squair JW, Franklin RJM, Tetzlaff W, Assinck P. Diversity of reactive astrogliosis in CNS pathology: Heterogeneity or plasticity? Front Cell Neurosci. 2021 Jul 26;15:703810. doi: 10.3389/fncel.2021.703810. eCollection 2021. [PMID: 34381334]

(18) Nikiforuk AM, Kuchinski KS, Twa DDW, Lukac CD, Sbihi H, Basham CA, Steidl C, Prystajecky NA, Jassem AN, Krajden M, Patrick DM, Sekirov I. The contrasting role of nasopharyngeal angiotensin converting enzyme 2 (ACE2) transcription in SARS-CoV-2 infection: A cross-sectional study of people tested for COVID-19 in British Columbia, Canada. EBioMedicine. 2021 Apr;66:103316. doi: 10.1016/j.ebiom.2021.103316. Epub 2021 Apr 2. [PMID: 33819740]

(19) Petersen C, Dai DLY, Boutin RCT, Sbihi H, Sears MR, Moraes TJ, Becker AB, Azad MB, Mandhane PJ, Subbarao P, Turvey SE, Finlay BB. A rich meconium metabolome in human infants is associated with early-life gut microbiota composition and reduced allergic sensitization.Cell Rep Med. 2021 Apr 29;2(5):100260. doi: 10.1016/j.xcrm.2021.100260. eCollection 2021 May 18. [PMID: 34095873]

(20) Qiu A, Nielsen TO. Synovial sarcoma oncogenesis revealed by single-cell profiling. Trends Cancer. 2021 Jun;7(6):482-483. doi: 10.1016/j.trecan.2021.03.002. Epub 2021 Apr 21. [PMID: 33893065]

(21) Ryzhaya N, Cermakova L, Trinder M, Ruel I, Coutinho T, Genest J, Brunham LR. Sex differences in the presentation, treatment, and outcome of patients with familial hypercholesterolemia. J Am Heart Assoc. 2021 May 25:e019286. doi: 10.1161/JAHA.120.019286. [PMID: 34032141]

(22) Skinnider MA, Cai C, Stacey RG, Foster LJ. PrInCE: an R/bioconductor package for protein-protein interaction network inference from co-fractionation mass spectrometry data. Bioinformatics. 2021 Jan 20:btab022. doi: 10.1093/bioinformatics/btab022. [PMID: 33471077]

(23) Skinnider MA, Foster LJ. Meta-analysis defines principles for the design and analysis of co-fractionation mass spectrometry experiments. Nat Methods. 2021 Jul;18(7):806-815. doi: 10.1038/s41592-021-01194-4. Epub 2021 Jul 1. [PMID: 34211188]

(24) Skinnider MA, Rogalski J, Tigchelaar S, Manouchehri N, Prudova A, Jackson AM, Nielsen K, Jeong J, Chaudhary S, Shortt K, Gallagher-Kurtzke Y, So K, Fong A, Gupta R, Okon EB, Rizzuto MA, Dong K, Streijger F, Belanger L, Ritchie L, Tsang A, Christie S, Mac-Thiong JM, Bailey C, Ailon T, Charest-Morin R, Dea N, Wilson JR, Dhall S, Paquette S, Street J, Fisher CG, Dvorak MF, Shannon C, Borchers C, Balshaw R, Foster LJ, Kwon BK. Proteomic portraits reveal evolutionarily conserved and divergent responses to spinal cord injury. Mol Cell Proteomics. 2021 Jun 12:100096. doi: 10.1016/j.mcpro.2021.100096. Online ahead of print. [PMID: 34129941]

(25) Skinnider MA, Scott NE, Prudova A, Kerr CH, Stoynov N, Stacey RG, Chan QWT, Rattray D, Gsponer J, Foster LJ. An atlas of protein-protein interactions across mouse tissues. Cell. 2021 Jul 22;184(15):4073-4089.e17. doi: 10.1016/j.cell.2021.06.003. Epub 2021 Jul 1. [PMID: 34214469]

(26) Skinnider MA, Squair JW, Courtine G. Enabling reproducible re-analysis of single-cell data. Genome Biol. 2021 Jul 26;22(1):215. doi: 10.1186/s13059-021-02422-y. [PMID: 34311752]

(27) Skinnider MA, Squair JW, Kathe C, Anderson MA, Gautier M, Matson KJE, Milano M, Hutson TH, Barraud Q, Phillips AA, Foster LJ, La Manno G, Levine AJ, Courtine G. Cell type prioritization in single-cell data. Nat Biotechnol. 2021 Jan;39(1):30-34. doi: 10.1038/s41587-020-0605-1. Epub 2020 Jul 20. [PMID: 32690972]

(28) Spence EEM, Hodge SVL, Rosentreter R, Lam T, Squair JW, Fisher JP, Phillips AA. Visual task complexity and eye movement patterns influence measures of human neurovascular coupling. Physiol Behav. 2021 Feb 1;229:113198. doi: 10.1016/j.physbeh.2020.113198. Epub 2020 Oct 14. [PMID: 33068563]

(29) Squair JW, Gautier M, Mahe L, Soriano JE, Rowald A, Bichat A, Cho N, Anderson MA, James ND, Gandar J, Incognito AV, Schiavone G, Sarafis ZK, Laskaratos A, Bartholdi K, Demesmaeker R, Komi S, Moerman C, Vaseghi B, Scott B, Rosentreter R, Kathe C, Ravier J, McCracken L, Kang X, Vachicouras N, Fallegger F, Jelescu I, Cheng Y, Li Q, Buschman R, Buse N, Denison T, Dukelow S, Charbonneau R, Rigby I, Boyd SK, Millar PJ, Moraud EM, Capogrosso M, Wagner FB, Barraud Q, Bezard E, Lacour SP, Bloch J, Courtine G, Phillips AA. Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury. Nature. 2021 Feb;590(7845):308-314. doi: 10.1038/s41586-020-03180-w. Epub 2021 Jan 27. [PMID: 33505019]

(30) Squair JW, Skinnider MA, Gautier M, Foster LJ, Courtine G. Prioritization of cell types responsive to biological perturbations in single-cell data with Augur. Nat Protoc. 2021 Aug;16(8):3836-3873. doi: 10.1038/s41596-021-00561-x. Epub 2021 Jun 25. [PMID: 34172974]

(31) Tessier-Cloutier B, Twa DD, Marzban M, Kalina J, Chun HE, Pavey N, Tanweer Z, Katz RL, Lum JJ, Salina D. The presence of tumour-infiltrating neutrophils is an independent adverse prognostic feature in clear cell renal cell carcinoma. J Pathol Clin Res. 2021 Jul;7(4):385-396. doi: 10.1002/cjp2.204. Epub 2021 Mar 4. [PMID: 33665979]

(32) Trinder M, Brunham LR. Polygenic scores for dyslipidemia: the emerging genomic model of plasma lipoprotein trait inheritance. Curr Opin Lipidol. 2021 Apr 1;32(2):103-111. doi: 10.1097/MOL.0000000000000737. [PMID: 33395106]

(33) Trinder M, Natarajan P. Clinical utility of lipoprotein(a) for screening does not determine clinical utility of lipoprotein(a) for the patient-reply. JAMA Cardiol. 2021 Jun 9. doi: 10.1001/jamacardio.2021.1589. Online ahead of print. [PMID: 34106217]

(34) Trinder M, Wang Y, Madsen CM, Ponomarev T, Bohunek L, Daisley BA, Kong HJ, Blauw LL, Nordestgaard BG, Tybjærg-Hansen A, Wurfel MM, Russell JA, Walley KR, Rensen PCN, Boyd JH, Brunham LR. Inhibition of cholesteryl ester transfer protein preserves high-density lipoprotein cholesterol and improves survival in sepsis. Circulation. 2021 Mar 2;143(9):921-934. doi: 10.1161/CIRCULATIONAHA.120.048568. Epub 2020 Nov 24. [PMID: 33228395]

(35) Trinder M, Zekavat SM, Uddin MM, Pampana A, Natarajan P. Apolipoprotein B is an insufficient explanation for the risk of coronary disease associated with lipoprotein(a). Cardiovasc Res. 2021 Feb 24:cvab060. doi: 10.1093/cvr/cvab060. [PMID: 33629108]

(36) Twa DD, Lee DG, Tan KL, Slack GW, Ben-Neriah S, Villa D, Connors JM, Sehn LH, Mottok A, Gascoyne RD, Scott DW, Steidl C, Savage KJ. Genomic predictors of central nervous system relapse in primary testicular diffuse large B-cell lymphoma. Blood. 2021 Mar 4;137(9):1256-1259. doi: 10.1182/blood.2020006338. [PMID: 32967007]

(37) Twa DD, Lukac CD, Kuchinski K, Nikiforuk A, Sekirov I. Neutrophils as a pallbearer for SARS-CoV-2 disease burden. Lancet Microbe. 2021 Feb;2(2):e56. doi: 10.1016/S2666-5247(21)00002-1. Epub 2021 Feb 2. [PMID: 33655231]

(38) Yuan PHS, MacLean LJ, Li EA, Yin S, Micieli JA. Publication rate of abstracts presented at the North American Neuro-Ophthalmology (NANOS) Society Annual Meeting from 2008 to 2017. J Neuroophthalmol. 2021 Jan 4;Publish Ahead of Print. doi: 10.1097/WNO.0000000000001158. Online ahead of print. [PMID: 33417420]

(39) Yuan PHS, Xu R, MacLean L, Muqaimi NA, Elmi M, Isaac KV. A call to bridge the divide in breast reconstruction research: A systematic review. J Plast Reconstr Aesthet Surg. 2021 Jun 20:S1748-6815(21)00342-9. doi: 10.1016/j.bjps.2021.06.008. Online ahead of print. [PMID: 34301512]

(40) Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S. Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies. PLoS Biol. 2021 Apr 29;19(4):e3001237. doi: 10.1371/journal.pbio.3001237. eCollection 2021 Apr. [PMID: 33914735]

2020 | Top

(01) Baillie KE, Stirling PC. Beyond kinases: Targeting replication stress proteins in cancer therapy. Trends Cancer. 2020 Nov 14:S2405-8033(20)30284-3. doi: 10.1016/j.trecan.2020.10.010. [PMID: 33203609]

(02) Barcik W, Boutin RCT, Sokolowska M, Finlay BB. The role of lung and gut microbiota in the pathology of asthma. Immunity. 2020 Feb 18;52(2):241-255. doi: 10.1016/j.immuni.2020.01.007. [PMID: 32075727]

(03) Boutin RCT, Sbihi H, Dsouza M, Malhotra R, Petersen C, Dai D, Sears MR, Moraes TJ, Becker AB, Azad MB, Mandhane PJ, Subbarao P, Finlay BB, Turvey SE. Mining the infant gut microbiota for therapeutic targets against atopic disease. Allergy. 2020 Aug;75(8). doi:10.1111/all.14244. Epub 2020 Mar 10. [PMID: 32086944]

(04) Castanov V, Zhou TE, Balestrini CS, Lefebvre C, Cook EK, Whittaker HT, Macklin J, Briard JN, Lazarte J, Trinder M, Ware MA, Hu S, Pietrobon A, Marvasti TB, Sivakami M. Overview of the Canadian Clinician Investigator Trainees’ research presented at the 2019 CSCI-CITAC Joint Meeting. Clin Invest Med. 2020 Sep 24;43(3):E5-14. doi: 10.25011/cim.v43i3.34522. [PMID: 32971579]

(05) D’Agostino MR, Lai R, Afkhami S, Khera A, Yao Y, Vaseghi-Shanjani M, Zganiacz A, Jeyanathan M, Xing Z.J Airway macrophages mediate mucosal vaccine-induced trained innate immunity against mycobacterium tuberculosis in early stages of infection. Immunol. 2020 Nov 15;205(10):2750-2762. doi: 10.4049/jimmunol.2000532. Epub 2020 Sep 30. [PMID: 32998983]

(06) Dancsok AR, Gao D, Lee AF, Steigen SE, Blay JY, Thomas DM, Maki RG, Nielsen TO, Demicco EG. Tumor-associated macrophages and macrophage-related immune checkpoint expression in sarcomas. Oncoimmunology. 2020 Apr 12;9(1):1747340. doi: 10.1080/2162402X.2020.1747340. eCollection 2020. [PMID: 32313727]

(07) Dixon K, Young S, Shen Y, Thibodeau ML, Fok A, Pleasance E, Zhao E, Jones M, Aubert G, Armstrong L, Virani A, Regier D, Gelmon K, Renouf D, Chia S, Bosdet I, Rassekh SR, Deyell RJ, Yip S, Fisic A, Titmuss E, Abadi S, Jones SJM, Sun S, Karsan A, Marra M, Laskin J, Lim H, Schrader KA. Establishing a framework for the clinical translation of germline findings in precision oncology. JNCI Cancer Spectr. 2020 May 29;4(5):pkaa045. doi: 10.1093/jncics/pkaa045. eCollection 2020 Oct. [PMID: 33134827]

(08) Ennishi D, Healy S, Bashashati A, Saberi S, Hother C, Mottok A, Chan FC, Chong L, Abraham L, Kridel R, Boyle M, Meissner B, Aoki T, Takata K, Woolcock BW, Viganò E, Gold M, Molday LL, Molday RS, Telenius A, Li MY, Wretham N, Dos Santos N, Wong M, Viller NN, Uger RA, Duns G, Baticados A, Madero A, Bristow BN, Farinha P, Slack GW, Ben-Neriah S, Lai D, Zhang AW, Salehi S, Shulha HP, Chiu DS, Mostafavi S, Gerrie AS, Huang DW, Rushton C, Villa D, Sehn LH, Savage KJ, Mungall AJ, Weng AP, Bally MB, Morin RD, Cohen Freue GV, Staudt LM, Connors JM, Marra MA, Shah SP, Gascoyne RD, Scott DW, Steidl C. TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma. Nat Med. 2020 Apr;26(4):577-588. doi: 10.1038/s41591-020-0757-z. Epub 2020 Feb 24. [PMID: 32094924]

(09) Fehr K, Moossavi S, Sbihi H, Boutin RCT, Bode L, Robertson B, Yonemitsu C, Field CJ, Becker AB, Mandhane PJ, Sears MR, Khafipour E, Moraes TJ, Subbarao P, Finlay BB, Turvey SE, Azad MB. Breastmilk feeding practices are associated with the co-occurrence of bacteria in mothers’ milk and the infant gut: the CHILD cohort study. Cell Host Microbe. 2020 Jul 9:S1931-3128 (20)30350-4. doi: 10.1016/j.chom.2020.06.009. [PMID: 32652062]

(10) Gee CM, Currie KD, Phillips AA, Squair JW, Krassioukov AV. Spinal cord injury impairs cardiovascular capacity in elite wheelchair rugby athletes. Clin J Sport Med. 2020 Jan;30(1):33-39. doi: 10.1097/JSM.0000000000000561. [PMID: 31855910]

(11) Gicas KM, Jones AA, Thornton AE, Petersson A, Livingston E, Waclawik K, Panenka WJ, Barr AM, Lang DJ, Vila-Rodriguez F, Leonova O, Procyshyn RM, Buchanan T, MacEwan GW, Honer WG. Cognitive decline and mortality in a community-based sample of homeless and precariously housed adults: 9-year prospective study. BJPsych Open. 2020 Feb 11;6(2):e21. doi: 10.1192/bjo.2020.3. [PMID: 32043436]

(12) Huang K, Trinder M, Roston TM, Laksman ZW, Brunham LR. The interplay between titin, polygenic risk and modifiable cardiovascular risk factors in atrial fibrillation. Can J Cardiol. 2020 Dec 26:S0828-282X(20)31195-8. doi: 10.1016/j.cjca.2020.12.024. [PMID: 33373724]

(13) Huus KE, Bauer KC, Brown EM, Bozorgmehr T, Woodward SE, Serapio-Palacios A, Boutin RCT, Petersen C, Finlay BB. Commensal bacteria modulate immunoglobulin a binding in response to host nutrition. Cell Host Microbe. 2020 Jun 10;27(6):909-921.e5. doi: 10.1016/j.chom.2020.03.012. Epub 2020 Apr 13. [PMID: 32289261]

(14) Ji JX, Cochrane DR, Tessier-Cloutier B, Chen SY, Ho G, Pathak KV, Alcazar IN, Farnell D, Leung S, Cheng A, Chow C, Colborne S, Negri GL, Kommoss F, Karnezis A, Morin GB, McAlpine JN, Gilks CB, Weissman BE, Trent JM, Hoang L, Pirrotte P, Wang Y, Huntsman DG. Arginine depletion therapy with ADI-PEG20 limits tumor growth in argininosuccinate synthase-deficient ovarian fancer, Including small-cell carcinoma of the ovary, hypercalcemic type. Clin Cancer Res. 2020 Aug 15;26(16):4402-4413. doi: 10.1158/1078-0432.CCR-19-1905. Epub 2020 May 14. [PMID: 32409304]

(15) Ji JX, Cochrane DR, Tessier-Cloutier B, Leung S, Cheng AS, Chow C, Gilks B, Huntsman DG, Hoang LN. Use of immunohistochemical markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to distinguish endometrial clear cell carcinoma from its morphologic mimics including arias-stellarReaction. Int J Gynecol Pathol. 2020 Jul;39(4):344-353. doi: 10.1097/PGP.0000000000000609. [PMID: 31094885]

(16) Jones AA, Gicas KM, Seyedin S, Willi TS, Leonova O, Vila-Rodriguez F, Procyshyn RM, Smith GN, Schmitt TA, Vertinsky AT, Buchanan T, Rauscher A, Lang DJ, MacEwan GW, Lima VD, Montaner JSG, Panenka WJ, Barr AM, Thornton AE, Honer WG. Associations of substance use, psychosis, and mortality among people living in precarious housing or homelessness: A longitudinal, community-based study in Vancouver, Canada.PLoS Med. 2020 Jul 6;17(7):e1003172. doi: 10.1371/journal.pmed.1003172. eCollection 2020 Jul. [PMID: 32628679]

(17) Jones PW, Thornton AE, Jones AA, Knerich VM, Lang DJ, Woodward ML, Panenka WJ, Su W, Barr AM, Buchanan T, Honer WG, Gicas KM. Amygdala nuclei volumes are selectively associated with social network size in homeless and precariously housed persons. Front Behav Neurosci. 2020 Jun 16;14:97. doi: 10.3389/fnbeh.2020.00097. eCollection 2020. [PMID: 32612516]

(18) Kerr CH, Skinnider MA, Andrews DDT, Madero AM, Chan QWT, Stacey RG, Stoynov N, Jan E, Foster LJ. Dynamic rewiring of the human interactome by interferon signaling. Genome Biol. 2020 Jun 15;21(1):140. doi: 10.1186/s13059-020-02050-y. [PMID: 32539747]

(19) Lau J, Rousseau J, Kwon D, Bénard F, Lin KS. A systematic review of molecular imaging agents targeting Bradykinin B1 and B2 receptors. Pharmaceuticals (Basel). 2020 Aug 17;13(8):199. doi: 10.3390/ph13080199. [PMID: 32824565]

(20) Lau J, Rousseau E, Kwon D, Lin K‐S, Bénard F, Chen X. Insight into the development of PET radiopharmaceuticals for oncology. Cancers (Basel). 2020 May 21;12(5):1312. doi: 10.3390/cancers12051312. [PMID: 32455729]

(21) Li EW, Lee A, Vaseghi-Shanjani M, Anagnostopoulos A, Jagelaviciute G, Kum E, Petraszko T, Elmoazzen H, Allan D, Fingrut W. Development and evaluation of a whiteboard video series to support the education and recruitment of committed unrelated donors for hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2020 Nov;26(11):2155-2164. doi: 10.1016/j.bbmt.2020.07.008. Epub 2020 Jul 14. [PMID: 32673743]

(22) Li W, Schäfer A, Kulkarni SS, Liu X, Martinez DR, Chen C, Sun Z, Leist SR, Drelich A, Zhang L, Ura ML, Berezuk A, Chittori S, Leopold K, Mannar D, Srivastava SS, Zhu X, Peterson EC, Tseng CT, Mellors JW, Falzarano D, Subramaniam S, Baric RS, Dimitrov DS. High potency of a bivalent human VH domain in SARS-CoV-2 animal models. Cell. 2020 Oct 15;183(2):429-441.e16. doi: 10.1016/j.cell.2020.09.007. Epub 2020 Sep 4. [PMID: 32941803 ]

(23) Merwin NJ, Mousa WK, Dejong CA, Skinnider MA, Cannon MJ, Li H, Dial K, Gunabalasingam M, Johnston C, Magarvey NA. DeepRiPP integrates multiomics data to automate discovery of novel ribosomally synthesized natural products. Proc Natl Acad Sci U S A. 2020 Jan 7;117(1):371-380. doi: 10.1073/pnas.1901493116. Epub 2019 Dec 23. [PMID: 31871149]

(24) Morjaria S, Zhang A, Kaltsas Md A, Parameswaran R, Patel D, Zhou W, Predmore J, Perez Johnston R, Jee J, Perales M, Daniyan A, Taur Y, Mailankody S. The effect of neutropenia and filgrastim (G-CSF) in cancer patients with COVID-19 Infection. medRxiv. 2020 Aug 15:2020.08.13.20174565. doi: 10.1101/2020.08.13.20174565. Preprint. [PMID: 32817981]

(25) Patrick DM, Sbihi H, Dai DLY, Al Mamun A, Rasali D, Rose C, Marra F, Boutin RCT, Petersen C, Stiemsma LT, Winsor GL, Brinkman FSL, Kozyrskyj AL, Azad MB, Becker AB, Mandhane PJ, Moraes TJ, Sears MR, Subbarao P, Finlay BB, Turvey SE. Decreasing antibiotic use, the gut microbiota, and asthma incidence in children: evidence from population-based and prospective cohort studies. Lancet Respir Med. 2020 Nov;8(11):1094-1105. doi: 10.1016/S2213-2600(20)30052-7. Epub 2020 Mar 24. [PMID: 32220282]

(26) Pors J, Segura S, Cheng A, Ji JX, Tessier-Cloutier B, Cochrane D, Fix DJ, Park K, Gilks B, Hoang L. Napsin-A and AMACR are superior to HNF-1β in distinguishing between mesonephric carcinomas and clear cell carcinomas of the gynecologic tract. Appl Immunohistochem Mol Morphol. 2020 Sep;28(8):593-601. doi: 10.1097/PAI.0000000000000801.[PMID: 31361605]

(27) Ramzy A, Asadi A, Kieffer TJ. Revisiting proinsulin processing: evidence that human β-cells process proinsulin with Prohormone Convertase (PC) 1/3 but Not PC2. Diabetes. 2020 Jul;69(7):1451-1462. doi: 10.2337/db19-0276. Epub 2020 Apr 14. [PMID: 32291281]

(28) Ramzy A, Tudurí E, Glavas MM, Baker RK, Mojibian M, Fox JK, O’Dwyer SM, Dai D, Hu X, Denroche HC, Edeer N, Gray SL, Verchere CB, Johnson JD, Kieffer TJ. AAV8 Ins1-Cre can produce efficient β-cell recombination but requires consideration of off-target effects. Sci Rep. 2020 Jun 29;10(1):10518. doi: 10.1038/s41598-020-67136-w. [PMID: 32601405]

(29) Rousseau E, Lau J, Zhang Z, Zhang C, Kwon D, Uribe CF, Kuo HT, Zeisler J, Bratanovic I, Lin KS, Bénard F. Comparison of biological properties of [177 Lu]Lu-ProBOMB1 and [177 Lu]Lu-NeoBOMB1 for GRPR targeting. J Labelled Comp Radiopharm. 2020 Feb;63(2):56-64. doi: 10.1002/jlcr.3815. Epub 2020 Jan 11. [PMID: 31715025]

(30) Saw J, Yang ML, Trinder M, Tcheandjieu C, Xu C, Starovoytov A, Birt I, Mathis MR, Hunker KL, Schmidt EM, Jackson L, Fendrikova-Mahlay N, Zawistowski M, Brummett CM, Zoellner S, Katz A, Coleman DM, Swan K, O’Donnell CJ; Million Veteran Program, Zhou X, Li JZ, Gornik HL, Assimes TL, Stanley JC, Brunham LR, Ganesh SK. Chromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction. Nat Commun. 2020 Sep 4;11(1):4432. doi: 10.1038/s41467-020-17558-x. [PMID: 32887874]

(31) Skinnider MA, Johnston CW, Gunabalasingam M, Merwin NJ, Kieliszek AM, MacLellan RJ, Li H, Ranieri MRM, Webster ALH, Cao MPT, Pfeifle A, Spencer N, To QH, Wallace DP, Dejong CA, Magarvey NA. Comprehensive prediction of secondary metabolite structure and biological activity from microbial genome sequences. Nat Commun. 2020 Nov 27;11(1):6058. doi: 10.1038/s41467-020-19986-1. [PMID: 33247171]

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(34) Swann SA, Campbell AR, Nicholson VJ, Murray MCM. Meaningful community collaboration in research. BCMJ. 62(9) 340-341. 2020. [full text]

(35) Trinder M, Brunham LR. Genetic confirmation of monogenic familial hypercholesterolemia advises a more intensive lipid-lowering approach-reply. JAMA Cardiol. 2020 Sep 16. doi: 10.1001/jamacardio.2020.4120. [PMID: 32936211]

(36) Trinder M, DeCastro ML, Azizi H, Cermakova L, Jackson LM, Frohlich J, Mancini GBJ, Francis GA, Brunham LR. Ascertainment bias in the association between elevated lipoprotein(a) and familial hypercholesterolemia. J Am Coll Cardiol. 2020 Jun 2;75(21):2682-2693. doi: 10.1016/j.jacc.2020.03.065. [PMID: 32466883]

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(38) Trinder M, Paquette M, Cermakova L, Ban MR, Hegele RA, Baass A, Brunham LR. Polygenic contribution to low-density lipoprotein cholesterol levels and cardiovascular risk in monogenic familial hypercholesterolemia. Circ Genom Precis Med. 2020 Oct;13(5):515-523. doi: 10.1161/CIRCGEN.120.002919. Epub 2020 Aug 13. [PMID: 33079599]

(39) Trinder M, Uddin MM, Finneran P, Aragam KG, Natarajan P. Clinical Utility of Lipoprotein(a) and LPA Genetic Risk Score in Risk Prediction of Incident Atherosclerotic Cardiovascular Disease. JAMA Cardiol. 2020 Oct 6;6(3):1-9. doi: 10.1001/jamacardio.2020.5398. [Epub ahead of print] [PMID: 33021622]

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2019 | Top

(01) Alexander PD, Gicas KM, Cheng A, Lang DJ, Procyshyn RM, Vertinsky AT, Panenka WJ, Thornton AE, Rauscher A, Wong JYX, Chan T, Jones AA, Vila-Rodriguez F, Honer WG, Barr AM. A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia. Psychopharmacology (Berl). 2019 Jun 22. doi: 10.1007/s00213-019-05298-w. [Epub ahead of print] [PMID: 31230145]

(02) Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez EA, Nissen M, Wang X, Miyata-Takata T, Lam V, Vigano E, Woolcock BW, Telenius A, Li MY, Healy S, Ghesquiere C, Kos D, Goodyear T, Veldman J, Zhang AW, Kim J, Saberi S, Ding J, Farinha P, Weng AP, Savage KJ, Scott DW, Krystal G, Nelson BH, Mottok A, Merchant A, Shah SP, Steidl C. Single cell transcriptome analysis reveals disease-defining T cell subsets in the tumor microenvironment of classic Hodgkin lymphoma. Cancer Discov. 2019 Dec 19. pii: CD-19-0680. doi: 10.1158/2159-8290.CD-19-0680. [PMID: 31857391]

(03) Bast RC Jr, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ Jr, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L. Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. 2019 Jun 15;125(12):1963-1972. doi: 10.1002/cncr.32004. Epub 2019 Mar 5. [PMID: 30835824]

(04) Cho N, Squair JW, Bloch J, Courtine G. Neurorestorative interventions involving bioelectronic implants after spinal cord injury. Bioelectron Med. 2019 Jul 11;5:10. doi: 10.1186/s42234-019-0027-x. eCollection 2019. [PMID: 32232100]

(05) Coombs GB, Barak OF, Phillips AA, Mijacika T, Sarafis ZK, Lee AHX, Squair JW, Bammert TD, DeSouza NM, Gagnon D, Krassioukov AV, Dujic Z, DeSouza CA, Ainslie PN. Acute heat stress reduces biomarkers of endothelial activation but not macro- or microvascular dysfunction in cervical spinal cord injury. Am J Physiol Heart Circ Physiol. 2019 Mar 1;316(3):H722-H733. doi: 10.1152/ajpheart.00693.2018. Epub 2018 Dec 21. [PMID: 30575438]

(06) Coombs GB, Vucina D, Caldwell HG, Barak OF, Mijacika T, Lee AHX, Sarafis ZK, Squair JW, Krassioukov AV, Phillips AA, Dujic Z, Ainslie PN. Cerebrovascular function is preserved during mild hyperthermia in cervical spinal cord injury. Spinal Cord. 2019 Nov;57(11):979-984. doi: 10.1038/s41393-019-0321-1. Epub 2019 Jul 9. [PMID: 31289366]

(07) Dancsok AR, Setsu N, Gao D, Blay JY, Thomas D, Maki RG, Nielsen TO, Demicco EG. Expression of lymphocyte immunoregulatory biomarkers in bone and soft-tissue sarcomas. Mod Pathol. 2019 Jul 1. doi: 10.1038/s41379-019-0312-y. [Epub ahead of print] [PMID: 31263176]

(08) Fraser S, Wright AD, van Donkelaar P, Smirl JD. Cross-sectional comparison of spiral versus block integrated curriculums in preparing medical students to diagnose and manage concussions. BMC Med Educ. 2019 Jan 9;19(1):17. doi: 10.1186/s12909-018-1439-0. [PMID: 30626361]

(09) Funnell T, Zhang AW, Grewal D, McKinney S, Bashashati A, Wang YK, Shah SP. Integrated structural variation and point mutation signatures in cancer genomes using correlated topic models. PLoS Comput Biol. 2019 Feb 22;15(2):e1006799. doi: 10.1371/journal.pcbi.1006799. eCollection 2019 Feb. [PMID: 30794536]

(10) Gicas KM, Cheng A, Rawtaer I, Willi TS, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Giesbrecht CJ, Jones AA, Barr AM, Procyshyn RM, Buchanan T, MacEwan GW, Su W, Vertinsky AT, Rauscher A, O’Rourke N, Loken Thornton W, Thornton AE, Honer WG. Diffusion tensor imaging of neurocognitive profiles in a community cohort living in marginal housing. Brain Behav. 2019 Mar;9(3):e01233. doi: 10.1002/brb3.1233. Epub 2019 Feb 6. [PMID: 30724486]

(11) Gicas KM, Jones AA, Panenka WJ, Giesbrecht C, Lang DJ, Vila-Rodriguez F, Leonova O, Barr AM, Procyshyn RM, Su W, Rauscher A, Vertinsky AT, Buchanan T, MacEwan GW, Thornton AE, Honer WG. Cognitive profiles and associated structural brain networks in a multimorbid sample of marginalized adults. PLoS One. 2019 Jun 13;14(6):e0218201. doi: 10.1371/journal.pone.0218201. eCollection 2019. [PMID: 31194834]

(12) Gicas KM, Thornton AE, Waclawik K, Wang N, Jones AA, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Barr AM, Procyshyn RM, Buchanan T, Su W, Vertinsky AT, Rauscher A, MacEwan GW, Honer WG. Volumes of the hippocampal formation differentiate component processes of memory in a community sample of homeless and marginally housed persons. Arch Clin Neuropsychol. 2019 Jun 1;34(4):548-562. doi: 10.1093/arclin/acy066. [PMID: 30407496]

(13) Grande BM, Gerhard DS, Jiang A, Griner NB, Abramson JS, Alexander TB, Allen H, Ayers LW, Bethony JM, Bhatia K, Bowen J, Casper C, Choi JK, Culibrk L, Davidsen TM, Dyer MA, Gastier-Foster JM, Gesuwan P, Greiner TC, Gross TG, Hanf B, Harris NL, He Y, Irvin JD, Jaffe ES, Jones SJM, Kerchan P, Knoetze N, Leal FE, Lichtenberg TM, Ma Y, Martin JP, Martin MR, Mbulaiteye SM, Mullighan CG, Mungall AJ, Namirembe C, Novik K, Noy A, Ogwang MD, Omoding A, Orem J, Reynolds SJ, Rushton CK, Sandlund JT, Schmitz R, Taylor C, Wilson WH, Wright GW, Zhao EY, Marra MA, Morin RD, Staudt LM. Genome-wide discovery of somatic coding and noncoding mutations in pediatric endemic and sporadic Burkitt lymphoma. Blood. 2019 Mar 21;133(12):1313-1324. doi: 10.1182/blood-2018-09-871418. Epub 2019 Jan 7. [PMID: 30617194]

(14) Harriman D, Singla R, Nguan C. The resident report card: A tool for operative feedback and evaluation of technical skills. J Surg Res. 2019 Jul;239:261-268. doi: 10.1016/j.jss.2019.02.006. Epub 2019 Mar 15. [PMID: 30884382]

(15) Hu R, Singla R, Deeba F, Rohling RN. Acoustic shadow detection: Study and statistics of B-Mode and radiofrequency data. Ultrasound Med Biol. 2019 Aug;45(8):2248-2257. doi: 10.1016/j.ultrasmedbio.2019.04.001. Epub 2019 May 14. [PMID: 31101443]

(16) Hu R, Singla R, Yan R, Mayer C, Rohling RN. Automated placenta segmentation with a convolutional neural network weighted by acoustic shadow detection.
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(17) Hubbard ME, Phillips AA, Charbonneau R, Squair JW, Parr AM, Krassioukov A. PRES secondary to autonomic dysreflexia: A case series and review of the literature. J Spinal Cord Med. 2019 May 29:1-7. doi: 10.1080/10790268.2019.1616146. [Epub ahead of print] [PMID: 31140946]

(18) Ji JX, Cochrane DR, Tessier-Cloutier B, Leung S, Cheng AS, Chow C, Gilks B, Huntsman DG, Hoang LN. Use of immunohistochemical markers (HNF-1β, Napsin A, ER, CTH, and ASS1) to distinguish endometrial clear cell carcinoma from its morphologic mimics including Arias-Stella reaction. Int J Gynecol Pathol. 2019 May 13. doi: 10.1097/PGP.0000000000000609. [Epub ahead of print] [PMID: 31094885]

(19) Jobin PG, Solis N, Machado Y, Bell PA, Kwon NH, Kim S, Overall CM, Butler GS. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. J Biol Chem. 2019 Aug 30;294(35):12866-12879. doi: 10.1074/jbc.RA119.009584. Epub 2019 Jul 19. [PMID: 31324718]

(20) Jobin PG, Solis N, Machado Y, Bell PA, Rai SK, Kwon NH, Kim S, Overall CM, Butler GS. Moonlighting matrix metalloproteinase substrates: Enhancement of proinflammatory functions of extracellular tyrosyl-tRNA synthetase upon cleavage. J Biol Chem. 2019 Nov 26. pii: jbc.RA119.010486. doi: 10.1074/jbc.RA119.010486. [PMID: 31771979]

(21) Knerich V, Jones AA, Seyedin S, Siu C, Dinh L, Mostafavi S, Barr AM, Panenka WJ, Thornton AE, Honer WG, Rutherford AR. Social and structural factors associated with substance use within the support network of adults living in precarious housing in a socially marginalized neighborhood of Vancouver, Canada. PLoS One. 2019 Sep 23;14(9):e0222611. doi: 10.1371/journal.pone.0222611. eCollection 2019. [PMID: 31545818]

(22) Kramer AI, Trinder M, Brunham LR. Estimating the prevalence of familial hypercholesterolemia in acute coronary syndrome: A systematic review and meta-analysis. Can J Cardiol. 2019 Jun 24. pii: S0828-282X(19)30433-7. doi: 10.1016/j.cjca.2019.06.017. [Epub ahead of print] Review. [PMID: 31500889]

(23) Lau J, Kwon D, Rousseau E, Zhang Z, Zeisler J, Uribe CF, Kuo HT, Zhang C, Lin KS, Bénard F. [68Ga]Ga/[177Lu]Lu-BL01, a novel theranostic pair for targeting C-X-C chemokine receptor 4. Mol Pharm. 2019 Oct 4. doi: 10.1021/acs.molpharmaceut.9b00808. [Epub ahead of print] [PMID: 31545614]

(24) Lau J, Rousseau E, Zhang Z, Uribe CF, Kuo HT, Zeisler J, Zhang C, Kwon D, Lin KS, Bénard F. Positron emission tomography imaging of the gastrin-releasing peptide receptor with a novel bombesin analogue. ACS Omega. 2019 Jan 31;4(1):1470-1478. doi: 10.1021/acsomega.8b03293. Epub 2019 Jan 16. [PMID: 30775647]

(25) Lever J, Zhao EY, Grewal J, Jones MR, Jones SJM. CancerMine: a literature-mined resource for drivers, oncogenes and tumor suppressors in cancer. Nat Methods. 2019 Jun;16(6):505-507. doi: 10.1038/s41592-019-0422-y. Epub 2019 May 20. [PMID: 31110280]

(26) Miranda A, Hamilton PT, Zhang AW, Pattnaik S, Becht E, Mezheyeuski A, Bruun J, Micke P, de Reynies A, Nelson BH. Cancer stemness, intratumoral heterogeneity, and immune response across cancers. Proc Natl Acad Sci U S A. 2019 Apr 30;116(18):9020-9029. doi: 10.1073/pnas.1818210116. Epub 2019 Apr 17. [PMID: 30996127]

(27) Ng E, Jones AA, Sivapragasam M, Nath S, Mak LE, Rosenblum ND. The integration of clinical and research training: How and why MD-PhD Programs work. Acad Med. 2019 May;94(5):664-670. doi: 10.1097/ACM.0000000000002467. [PMID: 30256250]

(28) Priest KC, Gorfinkel L, Klimas J, Jones AA, Fairbairn N, McCarty D. Comparing Canadian and United States opioid agonist therapy policies. Int J Drug Policy. 2019 Feb 11. pii: S0955-3959(19)30028-3. doi: 10.1016/j.drugpo.2019.01.020. [Epub ahead of print] [PMID: 30765118]

(29) O’Flanagan CH, Campbell KR, Zhang AW, Kabeer F, Lim JLP, Biele J, Eirew P, Lai D, McPherson A, Kong E, Bates C, Borkowski K, Wiens M, Hewitson B, Hopkins J, Pham J, Ceglia N, Moore R, Mungall AJ, McAlpine JN; CRUK IMAXT Grand Challenge Team, Shah SP, Aparicio S. Dissociation of solid tumor tissues with cold active protease for single-cell RNA-seq minimizes conserved collagenase-associated stress responses. Genome Biol. 2019 Oct 17;20(1):210. doi: 10.1186/s13059-019-1830-0. [PMID: 31623682]

(30) Saleem S, Sarafis ZK, Lee AHX, Squair JW, Barak OF, Sober-Williams E, Suraj R, Coombs GB, Mijacika T, West CR, Krassioukov AV, Ainslie PN, Dujic Z, Tzeng YC, Phillips AA. Spinal cord disruption is associated with a loss of cushing-like blood pressure interactions. J Neurotrauma. 2019 May 1;36(9):1487-1490. doi: 10.1089/neu.2018.5931. Epub 2019 Jan 8. [PMID: 30458117]

(31) Sbihi H, Boutin RCT, Cutler C, Suen M, Finlay BB, Turvey SE. Thinking bigger: How early life environmental exposures shape the gut microbiome and influence the development of asthma and allergic disease. Allergy. 2019 Apr 9. doi: 10.1111/all.13812. [Epub ahead of print] Review. [PMID: 30964945]

(32) Shen Y, Grisdale CJ, Islam SA, Bose P, Lever J, Zhao EY, Grinshtein N, Ma Y, Mungall AJ, Moore RA, Lun X, Senger DL, Robbins SM, Wang AY, MacIsaac JL, Kobor MS, Luchman HA, Weiss S, Chan JA, Blough MD, Kaplan DR, Cairncross JG, Marra MA, Jones SJM. Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19098-19108. doi: 10.1073/pnas.1813495116. Epub 2019 Aug 30. [PMID 31471491]

(33) Skinnider MA, Squair JW, Foster LJ. Evaluating measures of association for single-cell transcriptomics. Nat Methods. 2019 Apr 8. doi: 10.1038/s41592-019-0372-4. [Epub ahead of print] [PMID: 30962620]

(34) Smith-Dijak AI, Nassrallah WB, Zhang LYJ, Geva M, Hayden MR, Raymond LA. Impairment and restoration of homeostatic plasticity in cultured cortical neurons From a mouse model of Huntington disease. Front Cell Neurosci. 2019 May 16;13:209. doi: 10.3389/fncel.2019.00209. eCollection 2019. [PMID: 31156395]

(35) Squair JW, Bélanger LM, Tsang A, Ritchie L, Mac-Thiong JM, Parent S, Christie S, Bailey C, Dhall S, Charest-Morin R, Street J, Ailon T, Paquette S, Dea N, Fisher CG, Dvorak MF, West CR, Kwon BK. Empirical targets for acute hemodynamic management of individuals with spinal cord injury. Neurology. 2019 Sep 17;93(12):e1205-e1211. doi: 10.1212/WNL.0000000000008125. Epub 2019 Aug 13. [PMID: 31409736]

(36) Squair JW, Dhaliwal R, Cragg JJ, Charbonneau R, Grant C, Phillips AA. National survey of bladder and gastrointestinal dysfunction in people with spinal cord injury. J Neurotrauma. 2019 Jun 15;36(12):2011-2019. doi: 10.1089/neu.2018.5967. Epub 2019 Jan 25. [PMID: 30501555]

(37) Squair JW, Lee AH, Sarafis ZK, Chan F, Barak OF, Dujic Z, Day T, Phillips AA. Network analysis identifies consensus physiological measures of neurovascular coupling in humans. J Cereb Blood Flow Metab. 2019 Mar 6:271678X19831825. doi: 10.1177/0271678X19831825. [Epub ahead of print] [PMID: 30841780]

(38) Squair JW, Lee AHX, Sarafis ZK, Coombs G, Barak O, Cragg JJ, Mijacika T, Pecotic R, Krassioukov AV, Dogas Z, Dujic Z, Phillips AA. Sleep-disordered breathing is associated with brain vascular reactivity in spinal cord injury. Neurology. 2019 Dec 10;93(24):e2181-e2191. doi: 10.1212/WNL.0000000000008619. Epub 2019 Nov 6. [PMID: 31694923

(39) Tessier-Cloutier B, Twa DD, Baecklund E, Gascoyne R, Johnson NA, Backlin C, Kamen DL, Clarke AE, Ramsey-Goldman R, Lee JL, Farinha P, Bernatsky S. Cell of origin in diffuse large B-cell lymphoma in systemic lupus erythematosus: molecular and clinical factors associated with survival. Lupus Sci Med. 2019 May 4;6(1):e000324. doi: 10.1136/lupus-2019-000324. eCollection 2019. [PMID: 31205728]

(40) Thibodeau ML, Zhao EY, Reisle C, Ch’ng C, Wong HL, Shen Y, Jones MR, Lim HJ, Young S, Cremin C, Pleasance E, Zhang W, Holt R, Eirew P, Karasinska J, Kalloger SE, Taylor G, Majounie E, Bonakdar M, Zong Z, Bleile D, Chiu R, Birol I, Gelmon K, Lohrisch C, Mungall KL, Mungall AJ, Moore R, Ma YP, Fok A, Yip S, Karsan A, Huntsman D, Schaeffer DF, Laskin J, Marra MA, Renouf DJ, Jones SJM, Schrader KA. Base excision repair deficiency signatures implicate germline and somatic MUTYH aberrations in pancreatic ductal adenocarcinoma and breast cancer oncogenesis. Cold Spring Harb Mol Case Stud. 2019 Apr 1;5(2). pii: a003681. doi: 10.1101/mcs.a003681. Print 2019 Apr. [PMID: 30833417]

(41) Trinder M, Boyd JH, Brunham LR. Molecular regulation of plasma lipid levels during systemic inflammation and sepsis. Curr Opin Lipidol. 2019 Apr;30(2):108-116. doi: 10.1097/MOL.0000000000000577. [PMID: 30649022]

(42) Trinder M, Genga KR, Kong HJ, Blauw LL, Lo C, Li X, Cirstea M, Wang Y, Rensen PCN, Russell JA, Walley KR, Boyd JH, Brunham LR. Cholesteryl ester transfer protein influences high-density lipoprotein levels and survival in sepsis. Am J Respir Crit Care Med. 2019 Apr 1;199(7):854-862. doi: 10.1164/rccm.201806-1157OC. [PMID: 30321485]

(43) Trinder M, Li X, DeCastro ML, Cermakova L, Sadananda S, Jackson LM, Azizi H, Mancini GBJ, Francis GA, Frohlich J, Brunham LR. Monogenic familial hypercholesterolemia, polygenic hypercholesterolemia, and the risk of premature atherosclerotic cardiovascular disease. Atherosclerosis 287, e91. [PDF version]

(44) Trinder M, Li X, DeCastro ML, Cermakova L, Sadananda S, Jackson LM, Azizi H, Mancini GBJ, Francis GA, Frohlich J, Brunham LR. Risk of premature atherosclerotic disease in patients with monogenic versus polygenic familial hypercholesterolemia. J Am Coll Cardiol. 2019 Jul 30;74(4):512-522. doi: 10.1016/j.jacc.2019.05.043. [PMID: 31345425]

(45) Wen XY, Tarailo-Graovac M, Brand-Arzamendi K, Willems A, Rakic B, Huijben K, Da Silva A, Pan X, El-Rass S, Ng R, Selby K, Philip AM, Yun J, Ye XC, Ross CJ, Lehman AM, Zijlstra F, Abu Bakar N, Drögemöller B, Moreland J, Wasserman WW, Vallance H, van Scherpenzeel M, Karbassi F, Hoskings M, Engelke U, de Brouwer A, Wevers RA, Pshezhetsky AV, van Karnebeek CD, Lefeber DJ. Sialic acid catabolism by N-acetylneuraminate pyruvate lyase is essential for muscle function. JCI Insight. 2018 Dec 20;3(24). pii: 122373. doi: 10.1172/jci.insight.122373. [PMID: 30568043]

(46) Waclawik K, Jones AA, Barbic SP, Gicas KM, O’Connor TA, Smith GN, Leonova O, Mathias S, Barr AM, Procyshyn RM, Lang DJ, Woodward ML, MacEwan GW, Panenka WJ, Yamamoto A, Honer WG, Thornton AE. Cognitive impairment in marginally housed youth: Prevalence and risk Factors. Front Public Health. 2019 Oct 8;7:270. doi: 10.3389/fpubh.2019.00270. eCollection 2019. [PMID: 31649909]

(47) Williamson LM, Steel M, Grewal JK, Thibodeau ML, Zhao EY, Loree JM, Yang KC, Gorski SM, Mungall AJ, Mungall KL, Moore RA, Marra MA, Laskin J, Renouf DJ, Schaeffer DF, Jones SJM. Genomic characterization of a well-differentiated grade 3 pancreatic neuroendocrine tumor. Cold Spring Harb Mol Case Stud. 2019 Jun 3;5(3). pii: a003814. doi: 10.1101/mcs.a003814. Print 2019 Jun. [PMID: 31160355]

(48) Ye XC, van der Lee R, Wasserman WW. Curation and bioinformatic analysis of strabismus genes supports functional heterogeneity and proposes candidate genes with connections to RASopathies. Gene. 2019 May 20;697:213-226. doi: 10.1016/j.gene.2019.02.020. Epub 2019 Feb 15. [PMID: 30772522]

(49) Ye XC, van der Lee R, Wasserman WW, Causes Study, Friedman JM, Lehman A. Strabismus in children with intellectual disability: Part of a broader motor control phenotype? Pediatr Neurol. 2019 Nov;100:87-91. doi: 10.1016/j.pediatrneurol.2019.04.002. Epub 2019 Apr 11. [PMID: 31492586]

(50) Zhang AW, O’Flanagan C, Chavez EA, Lim JLP, Ceglia N, McPherson A, Wiens M, Walters P, Chan T, Hewitson B, Lai D, Mottok A, Sarkozy C, Chong L, Aoki T, Wang X, Weng AP, McAlpine JN, Aparicio S, Steidl C, Campbell KR, Shah SP. Probabilistic cell-type assignment of single-cell RNA-seq for tumor microenvironment profiling. Nat Methods. 2019 Sep 9. doi: 10.1038/s41592-019-0529-1. [Epub ahead of print] [PMID: 31501550]

(51) Zhou LW, Panenka WJ, Jones AA, Gicas KM, Thornton AE, Heran MKS, Volders D, Lang DJ, Vertinsky AT, Rauscher A, Su W, Barr AM, MacEwan GW, Honer WG, Field TS. Prevalence and risk factors of brain infarcts and associations with cognitive performance in tenants of marginal housing. J Am Heart Assoc. 2019 Jul 2;8(13):e011412. doi: 10.1161/JAHA.118.011412. Epub 2019 Jun 27. [PMID: 31242796]

(52) Zhu MMT, Dancsok AR, Nielsen TO. Indoleamine dioxygenase inhibitors: Clinical rationale and current development. Curr Oncol Rep. 2019 Jan 18;21(1):2. doi: 10.1007/s11912-019-0750-1. Review. [PMID: 30659394]

2018 | Top

(01) Arrieta MC, Arévalo A, Stiemsma L, Dimitriu P, Chico ME, Loor S, Vaca M, Boutin RCT, Morien E, Jin M, Turvey SE, Walter J, Parfrey LW, Cooper PJ, Finlay B. Associations between infant fungal and bacterial dysbiosis and childhood atopic wheeze in a nonindustrialized setting. J Allergy Clin Immunol. 2018 Aug;142(2):424-434.e10. doi: 10.1016/j.jaci.2017.08.041. Epub 2017 Dec 11. [PMID: 29241587]

(02) Arthur SE, Jiang A, Grande BM, Alcaide M, Cojocaru R, Rushton CK, Mottok A, Hilton LK, Lat PK, Zhao EY, Culibrk L, Ennishi D, Jessa S, Chong L, Thomas N, Pararajalingam P, Meissner B, Boyle M, Davidson J, Bushell KR, Lai D, Farinha P, Slack GW, Morin GB, Shah S, Sen D, Jones SJM, Mungall AJ, Gascoyne RD, Audas TE, Unrau P, Marra MA, Connors JM, Steidl C, Scott DW, Morin RD. Genome-wide discovery of somatic regulatory variants in diffuse large B-cell lymphoma. Nat Commun. 2018 Oct 1;9(1):4001. doi: 10.1038/s41467-018-06354-3. [PMID: 30275490]

(03) Banito A, Li X, Laporte AN, Roe JS, Sanchez-Vega F, Huang CH, Dancsok AR, Hatzi K, Chen CC, Tschaharganeh DF, Chandwani R, Tasdemir N, Jones KB, Capecchi MR, Vakoc CR, Schultz N, Ladanyi M, Nielsen TO, Lowe SW. The SS18-SSX oncoprotein hijacks KDM2B-PRC1.1 to drive synovial sarcoma. Cancer Cell. 2018 Mar 12;33(3):527-541.e8. doi: 10.1016/j.ccell.2018.01.018. Epub 2018 Mar 1. Erratum in: Cancer Cell. 2018 Aug 13;34(2):346-348. [PMID: 29502955]

(04) Barbic SP, Jones AA, Woodward M, Piercy M, Mathias S, Vila-Rodriguez F, Leonova O, Smith GN, Buchanan T, Vertinsky AT, Gillingham S, Panenka WJ, Rauscher A, Barr AM, Procyshyn RM, MacEwan GW, Lang DJ, Thornton AE, Heran MK, Leon AM, Krausz M, Honer WG. Clinical and functional characteristics of young adults living in single room occupancy housing: preliminary findings from a 10-year longitudinal study. Can J Public Health. 2018 Apr;109(2):204-214. doi: 10.17269/s41997-018-0087-9. Epub 2018 May 31. [PMID: 29981045]

(05) Baronas VA, Yang RY, Morales LC, Sipione S, Kurata HT. Slc7a5 regulates Kv1.2 channels and modifies functional outcomes of epilepsy-linked channel mutations. Nat Commun. 2018 Oct 24;9(1):4417. doi: 10.1038/s41467-018-06859-x. [PMID: 30356053]

(06) Boutin RCT, Dwyer Z, Farmer K, Rudyk C, Forbes MR, Hayley S.Perinatal antibiotic exposure alters composition of murine gut microbiota and may influence later responses to peanut antigen. Allergy Asthma Clin Immunol. 2018 Nov 1;14:42. doi: 10.1186/s13223-018-0263-8. eCollection 2018. [PMID 30410548]

(07) Burugu S, Dancsok AR, Nielsen TO. Emerging targets in cancer immunotherapy. Semin Cancer Biol. 2018 Oct;52(Pt 2):39-52. doi: 10.1016/j.semcancer.2017.10.001. Epub 2017 Oct 5. [PMID 28987965]

(08) De Souza RAG, Kosior N, Thomson SB, Mathelier A, Zhang AW, Bečanović K, Wasserman WW, Leavitt BR. Computational analysis of transcriptional regulation sites at the HTT gene locus. J Huntingtons Dis. 2018;7(3):223-237. doi: 10.3233/JHD-170272. [PMID 30103339]

(09) Dierijck JK, Wright AD, Smirl JD, Bryk K, van Donkelaar P. Sub-concussive trauma, acute concussion, and history of multiple concussions: Effects on quiet stance postural control stability. Int J Psychophysiol. 2018 Oct;132(Pt A):74-80. doi: 10.1016/j.ijpsycho.2018.03.005. Epub 2018 Mar 8. [PMID 29526776]

(10) Dufour A, Bellac CL, Eckhard U, Solis N, Klein T, Kappelhoff R, Fortelny N, Jobin P, Rozmus J, Mark J, Pavlidis P, Dive V, Barbour SJ, Overall CM. C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease. Nat Commun. 2018 Jun 20;9(1):2416. doi: 10.1038/s41467-018-04717-4. [PMID 29925830]

(11) Edgcumbe P, Singla R, Pratt P, Schneider C, Nguan C, Rohling R. Follow the light: projector-based augmented reality intracorporeal system for laparoscopic surgery. J Med Imaging (Bellingham). 2018 Apr;5(2):021216. doi: 10.1117/1.JMI.5.2.021216. Epub 2018 Feb 14. [PMID 29487888]

(12) Frias B, Phillips AA, Squair JW, Lee AHX, Laher I, Krassioukov AV. Reduced colonic smooth muscle cholinergic responsiveness is associated with impaired bowel motility after chronic experimental high-level spinal cord injury. Auton Neurosci. 2018 Sep 1. pii: S1566-0702(17)30319-3. doi: 10.1016/j.autneu.2018.08.005. [Epub ahead of print] [PMID 30196037]

(13) Genga KR, Trinder M, Kong HJ, Li X, Leung AKK, Shimada T, Walley KR, Russell JA, Francis GA, Brunham LR, Boyd JH. CETP genetic variant rs1800777 (allele A) is associated with abnormally low HDL-C levels and increased risk of AKI during sepsis. Sci Rep. 2018 Nov 13;8(1):16764. doi: 10.1038/s41598-018-35261-2. [PMID 30425299]

(14) Gicas KM, Thornton AE, Waclawik K, Wang N, Jones AA, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Barr AM, Procyshyn RM, Buchanan T, Su W, Vertinsky AT, Rauscher A, MacEwan GW, Honer WG. Volumes of the hippocampal formation differentiate component processes of memory in a community sample of homeless and marginally housed persons. Arch Clin Neuropsychol. 2018 Nov 8. doi: 10.1093/arclin/acy066. [Epub ahead of print] [PMID 30407496]

(15) Hastings MH, Qiu A, Zha C, Farah CA, Mahdid Y, Ferguson L, Sossin WS. The zinc fingers of the small optic lobes calpain bind polyubiquitin. J Neurochem. 2018 Aug;146(4):429-445. doi: 10.1111/jnc.14473. Epub 2018 Aug 2. [PMID 29808476]

(16) Ji JX, Wang YK, Cochrane DR, Huntsman DG. Clear cell carcinomas of the ovary and kidney: clarity through genomics. J Pathol. 2018 Apr;244(5):550-564. doi: 10.1002/path.5037. Epub 2018 Feb 23. Review. [PMID 29344971]

(17) Jones AA, Jang K, Panenka WJ, Barr AM, MacEwan GW, Thornton AE, Honer WG. Rapid change in fentanyl prevalence in a community-based, high-risk sample. JAMA Psychiatry. 2018 Mar 1;75(3):298-300. doi: 10.1001/jamapsychiatry.2017.4432. [PMID 29387869]

(18) Kennefick M, Wright AD, Smirl JD, van Donkelaar P. Anticipatory postural adjustments as a function of response complexity in simple reaction time tasks. Neurosci Lett. 2018 Sep 25;684:1-5. doi: 10.1016/j.neulet.2018.06.058. Epub 2018 Jun 30. [PMID 29969650]

(19) Kwon BK, Dhall S, Squair J, West C. Author response: Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury. Neurology. 2018 May 8;90(19):904. doi: 10.1212/WNL.0000000000005469. [PMID 29735777]

(20) Mackay JP, Nassrallah WB, Raymond LA. Cause or compensation? Altered neuronal Ca2+ handling in Huntington’s disease. CNS Neurosci Ther. 2018 Apr;24(4):301-310. doi: 10.1111/cns.12817. Epub 2018 Feb 9. Review. [PMID 29427371]

(21) Phillips AA, Matin N, Jia M, Squair JW, Monga A, Zheng MMZ, Sachdeva R, Yung A, Hocaloski S, Elliott S, Kozlowski P, Dorrance AM, Laher I, Ainslie PN, Krassioukov AV. Transient hypertension after spinal cord injury leads to cerebrovascular endothelial dysfunction and fibrosis. J Neurotrauma. 2018 Feb 1;35(3):573-581. doi: 10.1089/neu.2017.5188. Epub 2018 Jan 2. [PMID 29141501]

(22) Phillips AA, Squair JW, Sayenko DG, Edgerton VR, Gerasimenko Y, Krassioukov AV. An autonomic neuroprosthesis: Noninvasive electrical spinal cord stimulation restores autonomic cardiovascular function in individuals with spinal cord injury. J Neurotrauma. J Neurotrauma. 2018 Feb 1;35(3):446-451. doi: 10.1089/neu.2017.5082. Epub 2017 Nov 21. [PMID 28967294]

(23) Poormasjedi-Meibod MS, Mansouri M, Fossey M, Squair JW, Liu J, McNeill JH, West CR. Experimental spinal cord injury causes left-ventricular atrophy and is associated with an upregulation of proteolytic pathways. J Neurotrauma. 2018 Aug 13. doi: 10.1089/neu.2017.5624. [Epub ahead of print] [PMID 29877162]

(24) Pryzdial ELG, Lee FMH, Lin BH, Carter RLR, Tegegn TZ, Belletrutti MJ. Blood coagulation dissected. Transfus Apher Sci. 2018 Aug;57(4):449-457. doi: 10.1016/j.transci.2018.07.003. Epub 2018 Jul 20. Review. [PMID 30049564]

(25) Ramos-Miguel A, Jones AA, Sawada K, Barr AM, Bayer TA, Falkai P, Leurgans SE, Schneider JA, Bennett DA, Honer WG. Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age. Neurobiol Dis. 2018 Jun;114:31-44. doi: 10.1016/j.nbd.2018.02.006. Epub 2018 Feb 26. [PMID 29496544]

(26) Ramzy A, Mojibian M, Kieffer TJ. Insulin deficient mouse β-cells do not fully mature but can be remedied through insulin replacement by islet transplantation. Endocrinology. 2018 Jan 1;159(1):83-102. doi: 10.1210/en.2017-00263. [PMID 29029025]

(27) Ruiz IA, Squair JW, Phillips AA, Lukac CD, Huang D, Oxciano P, Yan D, Krassioukov AV. Incidence and natural progression of neurogenic shock after traumatic spinal cord injury. J Neurotrauma. 2018 Feb 1;35(3):461-466. doi: 10.1089/neu.2016.4947. Epub 2017 Dec 18. [PMID 29141498]

(28) Saleem S, Vucina D, Sarafis Z, H X Lee A, Squair JW, F Barak O, Coombs GB, Mijacika T, Krassioukov AV, Ainslie PN, Dujic Z, Tzeng YC, Phillips AA. Wavelet decomposition analysis is a clinically-relevant strategy to evaluate cerebrovascular buffering of blood pressure after spinal cord injury. Am J Physiol Heart Circ Physiol. 2018 May 1;314(5):H1108-H1114. doi: 10.1152/ajpheart.00152.2017. Epub 2018 Mar 30. [PMID 29600896]

(29) Skinnider MA, Johnston CW, Merwin NJ, Dejong CA, Magarvey NA. Global analysis of prokaryotic tRNA-derived cyclodipeptide biosynthesis. BMC Genomics. 2018 Jan 15;19(1):45. doi: 10.1186/s12864-018-4435-1. [PMID 29334896]

(30) Skinnider MA, Stacey RG, Foster LJ. Genomic data integration systematically biases interactome mapping. PLoS Comput Biol. 2018 Oct 17;14(10):e1006474. doi: 10.1371/journal.pcbi.1006474. eCollection 2018 Oct. [PMID 30332399]

(31) Skinnider MA, Twa DDW, Squair JW , Rosenblum ND, Lukac CD; Canadian MD/PhD Program Investigation Group. Predictors of sustained research involvement among MD/PhD programme graduates. Med Educ. 2018 May;52(5):536-545. doi: 10.1111/medu.13513. Epub 2018 Mar 13. [PMID 29532953]

(32) Smirl JD, Wright AD, Ainslie PN, Tzeng YC, van Donkelaar P. Differential systolic and diastolic regulation of the cerebral pressure-flow relationship during squat-stand manoeuvres. Acta Neurochir Suppl. 2018;126:263-268. doi: 10.1007/978-3-319-65798-1_52. [PMID 29492572]

(33) Squair JW, DeVeau KM, Harman KA, Poormasjedi-Meibod MS, Hayes B, Liu J, Magnuson DSK, Krassioukov AV, West CR. Spinal cord injury causes systolic dysfunction and cardiomyocyte atrophy. J Neurotrauma. 2018 Feb 1;35(3):424-434. doi: 10.1089/neu.2017.4984. Epub 2017 Oct 13. [PMID 28599602]

(34) Squair JW, Field TS, Phillips AA. Journal Club: Relationship between carotid arterial properties and cerebral white matter hyperintensities. Neurology. 2018 Feb 13;90(7):338-340. doi: 10.1212/WNL.0000000000004964. [PMID 29440542]

(35) Squair JW, Liu J, Tetzlaff W, Krassioukov AV, West CR. Spinal cord injury-induced cardiomyocyte atrophy and impaired cardiac function are severity dependent. Exp Physiol. 2018 Feb 1;103(2):179-189. doi: 10.1113/EP086549. Epub 2018 Jan 9. [PMID 29235182]

(36) Squair JW, Phillips AA, Currie KD, Gee C, Krassioukov AV. Autonomic testing for prediction of competition performance in Paralympic athletes. Scand J Med Sci Sports. 2018 Jan;28(1):311-318. doi: 10.1111/sms.12900. Epub 2017 May 22. [PMID 28452146]

(37) Squair JW, Ruiz I, Phillips AA, Zheng MMZ, Sarafis ZK, Sachdeva R, Gopaul R, Liu J, Tetzlaff W, West CR, Krassioukov AV. Minocycline reduces the severity of autonomic dysreflexia after experimental spinal cord injury. J Neurotrauma. 2018 Sep 8. doi: 10.1089/neu.2018.5703. [Epub ahead of print] [PMID 30113266]

(38) Squair JW, Tigchelaar S, Moon KM, Liu J, Tetzlaff W, Kwon BK, Krassioukov AV, West CR, Foster LJ, Skinnider MA. Integrated systems analysis reveals conserved gene networks underlying response to spinal cord injury. Elife. 2018 Oct 2;7. pii: e39188. doi: 10.7554/eLife.39188. [PMID 30277459]

(39) Stacey RG, Skinnider MA, Chik JHL, Foster LJ. Context-specific interactions in literature-curated protein interaction databases. BMC Genomics. 2018 Oct 19;19(1):758. doi: 10.1186/s12864-018-5139-2. [PMID 30340458]

(40) Thibodeau ML, Bonakdar M, Zhao E, Mungall KL, Reisle C, Zhang W, Bye MH, Thiessen N, Bleile D, Mungall AJ, Ma YP, Jones MR, Renouf DJ, Lim HJ, Yip S, Ng T, Ho C, Laskin J, Marra MA, Schrader KA, Jones SJM. Whole genome and whole transcriptome genomic profiling of a metastatic eccrine porocarcinoma. NPJ Precis Oncol. 2018 Mar 19;2(1):8. doi: 10.1038/s41698-018-0050-5. eCollection 2018. [PMID 29872726]

(41) Thibodeau ML, Reisle C, Zhao E, Martin LA, Alwelaie Y, Mungall KL, Ch’ng C, Thomas R, Ng T, Yip S, Lim H, Sun S, Young SS, Karsan A, Zhao Y, Mungall AJ, Moore RA, Renouf D, Gelmon K, Ma YP, Hayes M, Laskin J, Marra MA, Schrader KA, Jones SJM. Cold Spring Harb Mol Case Stud. 2018 Aug 1;4(4). pii: a003327. doi: 10.1101/mcs.a003327. Print 2018 Aug. Corrigendum: Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma. [PMID 30068734]

(42) Twa DDW, Mottok A, Savage KJ, Steidl C. The pathobiology of primary testicular diffuse large B-cell lymphoma: Implications for novel therapies. Blood Rev. 2018 May;32(3):249-255. doi: 10.1016/j.blre.2017.12.001. Epub 2017 Dec 20. Review. [PMID 29289361]

(43) Viganò E, Gunawardana J, Mottok A, Van Tol T, Mak K, Chan FC, Chong L, Chavez E, Woolcock B, Takata K, Twa D, Shulha HP, Telenius A, Kutovaya O, Hung SS, Healy S, Ben-Neriah S, Leroy K, Gaulard P, Diepstra A, Kridel R, Savage KJ, Rimsza L, Gascoyne R, Steidl C. Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation. Blood. 2018 May 3;131(18):2036-2046. doi: 10.1182/blood-2017-09-808907. Epub 2018 Feb 21. [PMID 29467182]

(44) Wallace C, Smirl JD, Zetterberg H, Blennow K, Bryk K, Burma J, Dierijck J, Wright AD, van Donkelaar P. Heading in soccer increases serum neurofilament light protein and SCAT3 symptom metrics. BMJ Open Sport Exerc Med. 2018 Aug 27;4(1):e000433. doi: 10.1136/bmjsem-2018-000433. eCollection 2018. [PMID 30233810]

(45) West CR, Phillips AA, Squair JW, Williams AM, Walter M, Lam T, Krassioukov AV. Association of epidural stimulation with cardiovascular function in an individual with spinal cord injury. JAMA Neurol. 2018 May 1;75(5):630-632. doi: 10.1001/jamaneurol.2017.5055. [PMID 29459943]

(46) Wong HL, Yang KC, Shen Y, Zhao EY, Loree JM, Kennecke HF, Kalloger SE, Karasinska JM, Lim HJ, Mungall AJ, Feng X, Davies JM, Schrader K, Zhou C, Karsan A, Jones SJM, Laskin J, Marra MA, Schaeffer DF, Gorski SM, Renouf DJ. Molecular characterization of metastatic pancreatic neuroendocrine tumors (PNETs) using whole-genome and transcriptome sequencing. Cold Spring Harb Mol Case Stud. 2018 Feb 1;4(1). pii: a002329. doi: 10.1101/mcs.a002329. Print 2018 Feb. [PMID 29092957]

(47) Wright AD, Smirl JD, Bryk K, Fraser S, Jakovac M, van Donkelaar P. Cerebral autoregulation is disrupted following a season of contact sports participation. Front Neurol. 2018 Oct 22;9:868. doi: 10.3389/fneur.2018.00868. eCollection 2018. [PMID 30405514]

(48) Wright AD, Smirl JD, Bryk K, Fraser S, Jakovac M, van Donkelaar P. Sport-related concussion alters indices of dynamic cerebral autoregulation. Front Neurol. 2018 Mar 27;9:196. doi: 10.3389/fneur.2018.00196. eCollection 2018. [PMID 29636724]

(49) Wright AD, Smirl JD, Bryk K, Jakovac M, van Donkelaar P. A prospective transcranial Doppler ultrasound-based evaluation of the effects of repetitive subconcussive head trauma on neurovascular coupling dynamics. Clin J Sport Med. 2018 Feb 14. doi: 10.1097/JSM.0000000000000578. [Epub ahead of print] [PMID 29461267]

(50) Wright AD, Smirl JD, Bryk K, van Donkelaar P. Systolic and diastolic regulation of the cerebral pressure-flow relationship differentially affected by acute sport-related concussion. Acta Neurochir Suppl. 2018;126:303-308. doi: 10.1007/978-3-319-65798-1_59. [PMID 29492579]

(51) Zhang AW, McPherson A, Milne K, Kroeger DR, Hamilton PT, Miranda A, Funnell T, Little N, de Souza CPE, Laan S, LeDoux S, Cochrane DR, Lim JLP, Yang W, Roth A, Smith MA, Ho J, Tse K, Zeng T, Shlafman I, Mayo MR, Moore R, Failmezger H, Heindl A, Wang YK, Bashashati A, Grewal DS, Brown SD, Lai D, Wan ANC, Nielsen CB, Huebner C, Tessier-Cloutier B, Anglesio MS, Bouchard-Côté A, Yuan Y, Wasserman WW, Gilks CB, Karnezis AN, Aparicio S, McAlpine JN, Huntsman DG, Holt RA, Nelson BH, Shah SP. Interfaces of malignant and immunologic clonal dynamics in ovarian cancer. CELL. 2018 Jun 14;173(7):1755-1769.e22. doi: 10.1016/j.cell.2018.03.073. Epub 2018 May 10. [PMID 29754820]

(52) Zhao EY, Jones M, Jones SJM. Whole-genome sequencing in cancer. Cold Spring Harb Perspect Med. 2018 May 29. pii: a034579. doi: 10.1101/cshperspect.a034579. [Epub ahead of print] [PMID 29844223]

2017 | Top

(01) Alexander PD, Gicas KM, Willi TS, Kim CN, Boyeva V, Procyshyn RM, Smith GN, Thornton AE, Panenka WJ, Jones AA, Vila-Rodriguez F, Lang DJ, William MacEwan G, Honer WG, Barr AM. A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence. Psychopharmacology (Berl). 2017 May;234(9-10):1535-1547. doi: 10.1007/s00213-017-4551-7. Epub 2017 Feb 11. [PMID 28190084]

(02) Baronas VA, Yang RY, Kurata HT. Extracellular redox sensitivity of Kv1.2 potassium channels. Sci Rep. 2017 Aug 22;7(1):9142. doi: 10.1038/s41598-017-08718-z. [PMID 28831076]

(03) Boutin RCT, Petersen C, Finlay BB. Microbial insights into asthmatic immunopathology. A forward-looking synthesis and commentary. Ann Am Thorac Soc. 2017 Nov;14(Supplement_5):S316-S325. doi: 10.1513/AnnalsATS.201707-534AW. [PMID 29161080]

(04) Dancsok AR, Asleh-Aburaya K, Nielsen TO. Advances in sarcoma diagnostics and treatment. Oncotarget. 2017 Jan 24;8(4):7068-7093. doi: 10.18632/oncotarget.12548. Review. [PMID 27732970]

(05) DeVeau KM, Harman KA, Squair JW, Krassioukov AV, Magnuson D, West CR. A comparison of passive hind-limb cycling and active upper-limb exercise provides new insights into systolic dysfunction following spinal cord injury. Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H861-H870. doi: 10.1152/ajpheart.00046.2017. Epub 2017 Jul 14. [PMID 28710067]

(06) Ellis C, Ramzy A, Kieffer TJ. Regenerative medicine and cell-based approaches to restore pancreatic function. Nat Rev Gastroenterol Hepatol. 2017 Oct;14(10):612-628. doi: 10.1038/nrgastro.2017.93. Epub 2017 Aug 16. [PMID 28811674]

(07) Gee CM, Currie KD, Phillips AA, Squair JW, Krassioukov AV. Spinal cord injury impairs cardiovascular capacity in elite wheelchair Rugby athletes. Clin J Sport Med. 2017 Dec 19. doi: 10.1097/JSM.0000000000000561. [Epub ahead of print] [PMID 29266029]

(08) Gicas KM, Giesbrecht CJ, Panenka WJ, Lang DJ, Smith GN, Vila-Rodriguez F, Leonova O, Jones AA, Barr AM, Procyshyn RM, Buchanan T, MacEwan GW, Su W, Vertinsky AT, Rauscher A, Honer WG, Thornton AE. Structural brain markers are differentially associated with neurocognitive profiles in socially marginalized people with multimorbid illness. Neuropsychology. 2017 Jan;31(1):28-43. doi: 10.1037/neu0000304. Epub 2016 Sep 19. [PMID 27643510]

(09) Honer WG, Cervantes-Larios A, Jones AA, Vila-Rodriguez F, Montaner JS, Tran H, Nham J, Panenka WJ, Lang DJ, Thornton AE, Vertinsky T, Barr AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, MacEwan GW, Gicas KM, Leonova O, Langheimer V, Rauscher A, Schultz K. The hotel study – clinical and health service effectiveness in a cohort of homeless or marginally housed persons. Can J Psychiatry. 2017 Jul;62(7):482-492. doi: 10.1177/0706743717693781. Epub 2017 Feb 15. [PMID 28199798]

(10) Jobin PG, Butler GS, Overall CM. New intracellular activities of matrix metalloproteinases shine in the moonlight. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt A):2043-2055. doi: 10.1016/j.bbamcr.2017.05.013. Epub 2017 May 16. [PMID 28526562]

(11) Lee AHX, Phillips AA, Squair JW, Barak OF, Coombs GB, Ainslie PN, Sarafis ZK, Mijacika T, Vucina D, Dujic Z, Krassioukov AV. Alarming blood pressure changes during routine bladder emptying in a woman with cervical spinal cord injury. Spinal Cord Ser Cases. 2017 Dec 28;3:17101. doi: 10.1038/s41394-017-0022-y. eCollection 2017. [PMID 29423304]

(12) Nunes PSG, Zhang Z, Kuo HT, Zhang CC, Rousseau J, Rousseau E, Lau J, Kwon D, Carvalho I, Bénard F, Lin KS. Synthesis and evaluation of an 18F-labeled trifluoroborate derivative of 2-nitroimidazole for imaging tumor hypoxia with positron emission tomography. Wiley Online Library. 2017. [PDF version] [PMID 29247455]

(13) Phillips AA, Squair JW, Currie KD, Tzeng YC, Ainslie PN, Krassioukov AV. 2015 ParaPan American Games: Autonomic function, but not physical activity, is associated with vascular-cognitive impairment in spinal cord injury. J Neurotrauma. 2017 Mar 15;34(6):1283-1288. doi: 10.1089/neu.2016.4751. Epub 2017 Jan 27. [PMID 27998205]

(14) Phillips AA, Squair JW, Krassioukov AV. Paralympic medicine: The road to Rio. J Neurotrauma. 2017 Jun 1;34(11):2001-2005. doi: 10.1089/neu.2016.4715. Epub 2017 Jan 24. [PMID 27998237]

(15) Ramos-Miguel A, Sawada K, Jones AA, Thornton AE, Barr AM, Leurgans SE, Schneider JA, Bennett DA, Honer WG. Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer’s disease. Acta Neuropathol. 2017 Mar;133(3):395-407. doi: 10.1007/s00401-016-1647-9. Epub 2016 Nov 19. [PMID 27866231]

(16) Seid-Karbasi P, Ye XC, Zhang AW, Gladish N, Cheng SY, Rothe K, Pilsworth JA, Kang MA, Doolittle N, Jiang X, Stirling PC, Wasserman WW. CuboCube: Student creation of a cancer genetics e-textbook using open-access software for social learning. PLoS Biol. 2017 Mar 7;15(3):e2001192. doi: 10.1371/journal.pbio.2001192. eCollection 2017 Mar. [PMID 28267757]

(17) Singla R, Edgcumbe P, Pratt P, Nguan C, Rohling R. Intra-operative ultrasound-based augmented reality guidance for laparoscopic surgery. Healthc Technol Lett. 2017 Sep 11;4(5):204-209. doi: 10.1049/htl.2017.0063. eCollection 2017 Oct. [PMID 29184666]

(18) Siu C, Wiseman S, Gakkhar S, Heravi-Moussavi A, Bilenky M, Carles A, Sierocinski T, Tam A, Zhao E, Kasaian K, Moore RA, Mungall AJ, Walker B, Thomson T, Marra MA, Hirst M, Jones SJM. Characterization of the human thyroid epigenome. J Endocrinol. 2017 Nov;235(2):153-165. doi: 10.1530/JOE-17-0145. Epub 2017 Aug 14. [PMID 28808080]

(19) Skinnider MA, Dejong CA, Franczak BC, McNicholas PD, Magarvey NA. Comparative analysis of chemical similarity methods for modular natural products with a hypothetical structure enumeration algorithm. J Cheminform. 2017 Aug 16;9(1):46. doi: 10.1186/s13321-017-0234-y. [PMID 29086195]

(20) Skinnider MA, Magarvey NA. Statistical reanalysis of natural products reveals increasing chemical diversity. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6271-E6272. doi: 10.1073/pnas.1708560114. Epub 2017 Jul 14. [PMID 28710332]

(21) Skinnider MA, Merwin NJ, Johnston CW, Magarvey NA. PRISM 3: Expanded prediction of natural product chemical structures from microbial genomes. Nucleic Acids Res. 2017 Jul 3;45(W1):W49-W54. doi: 10.1093/nar/gkx320. [PMID 28460067]

(22) Skinnider MA, Squair JW, Twa DDW, Ji JX, Kuzyk A, Wang X, Steadman PE, Zaslavsky K, Dey AK, Eisenberg MJ, Gagné ÈR, HayGlass KT, Lewis JF, Margetts PJ, Underhill DA, Rosenblum ND, Raymond LA. Characteristics and outcomes of Canadian MD/PhD program graduates: a cross-sectional survey. CMAJ Open. 2017 Apr 25;5(2):E308-E314. doi: 10.9778/cmajo.20160152. [PMID 28442493]

(23) Squair JW, Bélanger LM, Tsang A, Ritchie L, Mac-Thiong JM, Parent S, Christie S, Bailey C, Dhall S, Street J, Ailon T, Paquette S, Dea N, Fisher CG, Dvorak MF, West CR, Kwon BK. Spinal cord perfusion pressure predicts neurologic recovery in acute spinal cord injury. Neurology. 2017 Oct 17;89(16):1660-1667. doi: 10.1212/WNL.0000000000004519. Epub 2017 Sep 15. [PMID 28916535]

(24) Squair JW, West CR, Popok D, Assinck P, Liu J, Tetzlaff W, Krassioukov AV. High thoracic contusion model for the investigation of cardiovascular function after spinal cord injury. J Neurotrauma. 2017 Feb;34(3):671-684. doi: 10.1089/neu.2016.4518. Epub 2016 Aug 25. [PMID 27456150]

(25) Stacey RG, Skinnider MA, Scott NE, Foster LJ. A rapid and accurate approach for prediction of interactomes from co-elution data (PrInCE). BMC Bioinformatics. 2017 Oct 23;18(1):457. doi: 10.1186/s12859-017-1865-8. [PMID 29061110]

(26) Streijger F, Skinnider MA, Rogalski JC, Balshaw R, Shannon CP, Prudova A, Belanger L, Ritchie L, Tsang A, Christie S, Parent S, Mac-Thiong JM, Bailey C, Urquhart J, Ailon T, Paquette S, Boyd M, Street J, Fisher CG, Dvorak MF, Borchers CH, Foster LJ, Kwon BK. A targeted proteomics analysis of cerebrospinal fluid after acute human spinal cord injury. J Neurotrauma. 2017 Jun 15;34(12):2054-2068. doi: 10.1089/neu.2016.4879. Epub 2017 Apr 7. [PMID 28276985]

(27) Thibodeau ML, Reisle C, Zhao E, Martin LA, Alwelaie Y, Mungall KL, Ch’ng C, Thomas R, Ng T, Yip S, Lim H, Sun S, Young SS, Karsan A, Zhao Y, Mungall AJ, Moore RA, Renouf D, Gelmon K, Ma YP, Hayes M, Laskin J, Marra MA, Schrader KA, Jones SJM. Genomic profiling of pelvic genital type leiomyosarcoma in a woman with a germline CHEK2:c.1100delC mutation and a concomitant diagnosis of metastatic invasive ductal breast carcinoma. Cold Spring Harb Mol Case Stud. 2017 Sep 1;3(5). pii: a001628. doi: 10.1101/mcs.a001628. Print 2017 Sep. [PMID 28514723]

(28) Twa DDW, Skinnider MA, Squair JW, Lukac CD; Canadian MD/PhD Program Investigation Group. Cross-sectional-derived determinants of satisfaction with physician-scientist training among Canadian MD/PhD graduates. PLoS One. 2017 Sep 28;12(9):e0185218. doi: 10.1371/journal.pone.0185218. eCollection 2017. [PMID 28957354]

(29) Wang YK, Bashashati A, Anglesio MS, Cochrane DR, Grewal DS, Ha G, McPherson A, Horlings HM, Senz J, Prentice LM, Karnezis AN, Lai D, Aniba MR, Zhang AW, Shumansky K, Siu C, Wan A, McConechy MK, Li-Chang H, Tone A, Provencher D, de Ladurantaye M, Fleury H, Okamoto A, Yanagida S, Yanaihara N, Saito M, Mungall AJ, Moore R, Marra MA, Gilks CB, Mes-Masson AM, McAlpine JN, Aparicio S, Huntsman DG, Shah SP. Genomic consequences of aberrant DNA repair mechanisms stratify ovarian cancer histotypes. Nat Genet. 2017 Jun;49(6):856-865. doi: 10.1038/ng.3849. Epub 2017 Apr 24. [PMID 28436987]

(30) Woodsworth DJ, Dreolini L, Abraham L, Holt RA. Targeted cell-to-cell delivery of protein payloads via the granzyme-perforin pathway. Mol Ther Methods Clin Dev. 2017 Oct 10;7:132-145. doi: 10.1016/j.omtm.2017.10.003. eCollection 2017 Dec 15. [PMID 29201936]

(31) Woodsworth DJ, Holt RA. Cell-based therapeutics: Making a faustian pact with biology. Trends Mol Med. 2017 Feb;23(2):104-115. doi: 10.1016/j.molmed.2016.12.004. Epub 2017 Jan 25. Review. [PMID 28129958]

(32) Wright AD, Smirl JD, Bryk K, van Donkelaar P. A prospective transcranial Doppler ultrasound-based evaluation of the acute and cumulative effects of sport-related concussion on neurovascular coupling response dynamics. J Neurotrauma. 2017 Nov 15;34(22):3097-3106. doi: 10.1089/neu.2017.5020. Epub 2017 Aug 4. [PMID 28627298]

(33) Zhao EY, Shen Y, Pleasance E, Kasaian K, Leelakumari S, Jones M, Bose P, Ch’ng C, Reisle C, Eirew P, Corbett R, Mungall KL, Thiessen N, Ma Y, Schein JE, Mungall AJ, Zhao Y, Moore RA, Den Brok W, Wilson S, Villa D, Shenkier T, Lohrisch C, Chia S, Yip S, Gelmon K, Lim H, Renouf D, Sun S, Schrader KA, Young S, Bosdet I, Karsan A, Laskin J, Marra MA, Jones SJM. Homologous recombination deficiency and platinum-based therapy outcomes in advanced breast cancer. Clin Cancer Res. 2017 Dec 15;23(24):7521-7530. doi: 10.1158/1078-0432.CCR-17-1941. [PMID 29246904]

2016 | Top

(01) Baronas VA, Yang R, Vilin YY, Kurata HT. Determinants of frequency-dependent regulation of Kv1.2-containing potassium channels. Channels (Austin). 2016;10(2):158-66. doi: 10.1080/19336950.2015.1120390. Epub 2015 Dec 8. [PMID 26646078]

(02) Boutin RCT, Finlay BB. (2016) Microbiota-mediated immunomodulation and asthma: Current and future perspectives. Curr Treat Options Allergy. 3:292–309. [PDF version]

(03) Chong LC, Twa DD, Mottok A, Ben-Neriah S, Woolcock BW, Zhao Y, Savage KJ, Marra MA, Scott DW, Gascoyne RD, Morin RD, Mungall AJ, Steidl C. Comprehensive characterization of programmed death ligand structural rearrangements in B-cell non-Hodgkin lymphomas. Blood. 2016 Sep 1;128(9):1206-13. doi: 10.1182/blood-2015-11-683003. Epub 2016 Jun 7. [PMID 27268263]

(04) Crabtree A, Latham N, Bird L, Buxton J. Results of a participatory needs assessment demonstrate an opportunity to involve people who use alcohol in drug user activism and harm reduction. Harm Reduct J. 2016 Dec 9;13(1):37. [PMID 27938376]

(05) Dejong CA, Chen GM, Li H, Johnston CW, Edwards MR, Rees PN, Skinnider MA, Webster AL, Magarvey NA. Polyketide and nonribosomal peptide retro-biosynthesis and global gene cluster matching. Nat Chem Biol. 2016 Dec;12(12):1007-1014. doi: 10.1038/nchembio.2188. Epub 2016 Oct 3. [PMID 27694801]

(06) Jamshidi F, Bashashati A, Shumansky K, Dickson B, Gokgoz N, Wunder JS, Andrulis IL, Lazar A, Shah SP, Huntsman DG, Nielsen TO. The genomic landscape of epithelioid sarcoma cell lines and tumors. J Pathol. 2016 Jan;238(1):63-73. doi: 10.1002/path.4636. Epub 2015 Oct 19. [PMID 26365879]

(07) Johnston CW, Connaty AD, Skinnider MA, Li Y, Grunwald A, Wyatt MA, Kerr RG, Magarvey NA. Informatic search strategies to discover analogues and variants of natural product archetypes. J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):293-8. doi: 10.1007/s10295-015-1675-9. Epub 2015 Sep 8. [PMID 26350080]

(08) Johnston CW, Skinnider MA, Dejong CA, Rees PN, Chen GM, Walker CG, French S, Brown ED, Bérdy J, Liu DY, Magarvey NA. Assembly and clustering of natural antibiotics guides target identification. Nat Chem Biol. 2016 Apr;12(4):233-9. doi: 10.1038/nchembio.2018. Epub 2016 Feb 1. [PMID 26829473]

(09) Jones AA, Ng E, Deguise MO, Mak L, Ouyang B, Sivapragasam M, MacNairn IA, Narth S, Benesch MG, Forrest L, Wang X. MD/PhD training in Canada: Results from a national trainee and program director review. Clin Invest Med. 2016 Sep 11;39(4):E132-9. [PMID 27619400]

(10) Kostoglou K, Wright AD, Smirl JD, Bryk K, van Donkelaar P, Mitsis GD. Dynamic cerebral autoregulation in young athletes following concussion. Conf Proc IEEE Eng Med Biol Soc. 2016 Aug;2016:696-699. doi: 10.1109/EMBC.2016.7590797. [PMID 28268423]

(11) Laporte AN, Ji JX, Ma L, Nielsen TO, Brodin BA. Identification of cytotoxic agents disrupting synovial sarcoma oncoprotein interactions by proximity ligation assay. Oncotarget. 2016 Jun 7;7(23):34384-94. doi: 10.18632/oncotarget.8882. [PMID 27120803]

(12) Li V, Wang YT. Molecular mechanisms of NMDA receptor-mediated excitotoxicity: implications for neuroprotective therapeutics for stroke. Neural Regen Res. 2016 Nov;11(11):1752-1753. doi: 10.4103/1673-5374.194713. [PMID 28123410]

(13) Mathelier A, Fornes O, Arenillas DJ, Chen CY, Denay G, Lee J, Shi W, Shyr C, Tan G, Worsley-Hunt R, Zhang AW, Parcy F, Lenhard B, Sandelin A, Wasserman WW. JASPAR 2016: a major expansion and update of the open-access database of transcription factor binding profiles. Nucleic Acids Res. 2016 Jan 4;44(D1):D110-5. doi: 10.1093/nar/gkv1176. Epub 2015 Nov 3. [PMID 26531826]

(14) McPherson A, Roth A, Laks E, Masud T, Bashashati A, Zhang AW, Ha G, Biele J, Yap D, Wan A, Prentice LM, Khattra J, Smith MA, Nielsen CB, Mullaly SC, Kalloger S, Karnezis A, Shumansky K, Siu C, Rosner J, Chan HL, Ho J, Melnyk N, Senz J, Yang W, Moore R, Mungall AJ, Marra MA, Bouchard-Côté A, Gilks CB, Huntsman DG, McAlpine JN, Aparicio S, Shah SP. Divergent modes of clonal spread and intraperitoneal mixing in high-grade serous ovarian cancer. Nat Genet. 2016 Jul;48(7):758-67. doi: 10.1038/ng.3573. Epub 2016 May 16. [PMID 27182968]

(15) Pon JR, Marra MA. Clinical correlates of molecular features in diffuse large B-cell lymphoma and follicular lymphoma. Blood. 2016 Jan 14;127(2):181-6. doi: 10.1182/blood-2015-07-658401. Epub 2015 Oct 7. [PMID 26447189]

(16) Pon JR, Marra MA. MEF2 transcription factors: developmental regulators and emerging cancer genes. Oncotarget. Oncotarget. 2016 Jan 19;7(3):2297-312. doi: 10.18632/oncotarget.6223. Review. [PMID 26506234]

(17) Pryzdial EL, Meixner SC, Talbot K, Eltringham-Smith LJ, Baylis JR, Lee FM, Kastrup CJ, Sheffield WP. Thrombolysis by chemically modified coagulation factor Xa. J Thromb Haemost. 2016 Sep;14(9):1844-54. doi: 10.1111/jth.13402. Epub 2016 Aug 17. [PMID 27359348]

(18) Sheffield BS, Fulton R, Kalloger SE, Milne K, Geller G, Jones M, Jacquemont C, Zachara S, Zhao E, Pleasance E, Laskin J, Jones SJ, Marra MA, Yip S, Nelson BH, Gown AM, Ho C, Ionescu DN. Investigation of PD-L1 biomarker testing methods for PD-1 axis inhibition in non-squamous non-small cell lung cancer. J Histochem Cytochem. 2016 Oct;64(10):587-600. doi: 10.1369/0022155416665338. Epub 2016 Sep 2. [PMID 27591097]

(19) Skinnider MA, Johnston CW, Edgar RE, Dejong CA, Merwin NJ, Rees PN, Magarvey NA. Genomic charting of ribosomally synthesized natural product chemical space facilitates targeted mining. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):E6343-E6351. Epub 2016 Oct 3. [PMID 27698135]

(20) Smirl JD, Wright AD, Bryk K, van Donkelaar P. Where’s Waldo? The utility of a complicated visual search paradigm for transcranial Doppler-based assessments of neurovascular coupling. J Neurosci Methods. 2016 Sep 1;270:92-101. doi: 10.1016/j.jneumeth.2016.06.007. Epub 2016 Jun 9. [PMID 27291357]

(21) Squair JW, Bjerkefors A, Inglis JT, Lam T, Carpenter MG. Cortical and vestibular stimulation reveal preserved descending motor pathways in individuals with motor-complete spinal cord injury. J Rehabil Med. 2016 Jul 18;48(7):589-96. doi: 10.2340/16501977-2101. [PMID 27292455]

(22) Squair JW, Phillips AA, Harmon M, Krassioukov AV. Emergency management of autonomic dysreflexia with neurologic complications. CMAJ. 2016 Oct 18;188(15):1100-1103. Epub 2016 May 24. [PMID 27221275]

(23) Squair JW, White BA, Bravo GI, Martin Ginis KA, Krassioukov AV. The economic burden of autonomic dysreflexia during hospitalization for individuals with spinal cord injury. J Neurotrauma. 2016 Aug 1;33(15):1422-7. doi: 10.1089/neu.2015.4370. Epub 2016 Mar 22. [PMID 27002855]

(24) Tarailo-Graovac M, Shyr C, Ross CJ, Horvath GA, Salvarinova R, Ye XC, Zhang LH, Bhavsar AP, Lee JJ, Drögemöller BI, Abdelsayed M, Alfadhel M, Armstrong L, Baumgartner MR, Burda P, Connolly MB, Cameron J, Demos M, Dewan T, Dionne J, Evans AM, Friedman JM, Garber I, Lewis S, Ling J, Mandal R, Mattman A, McKinnon M, Michoulas A, Metzger D, Ogunbayo OA, Rakic B, Rozmus J, Ruben P, Sayson B, Santra S, Schultz KR, Selby K, Shekel P, Sirrs S, Skrypnyk C, Superti-Furga A, Turvey SE, Van Allen MI, Wishart D, Wu J, Wu J, Zafeiriou D, Kluijtmans L, Wevers RA, Eydoux P, Lehman AM, Vallance H, Stockler-Ipsiroglu S, Sinclair G, Wasserman WW, van Karnebeek CD. Exome sequencing and the management of neurometabolic disorders. N Engl J Med. 2016 Jun 9;374(23):2246-55. doi: 10.1056/NEJMoa1515792. Epub 2016 May 25. [PMID 27276562]

(25) West CR, Squair JW, McCracken L, Currie KD, Somvanshi R, Yuen V, Phillips AA, Kumar U, McNeill JH, Krassioukov AV. Cardiac consequences of autonomic dysreflexia in spinal cord injury. Hypertension. 2016 Nov;68(5):1281-1289. Epub 2016 Oct 3. [PMID 27698067]

(26) Westwell-Roper C, Denroche HC, Ehses JA, Verchere CB. Differential activation of innate immune pathways by distinct islet amyloid polypeptide (IAPP) aggregates. J Biol Chem. 2016 Apr 22;291(17):8908-17. doi: 10.1074/jbc.M115.712455. Epub 2016 Jan 19. [PMID 26786104]

(27) Wijesekara N, Kaur A, Westwell-Roper C, Nackiewicz D, Soukhatcheva G, Hayden MR, Verchere CB. ABCA1 deficiency and cellular cholesterol accumulation increases islet amyloidogenesis in mice. Diabetologia. 2016 Jun;59(6):1242-6. doi: 10.1007/s00125-016-3907-6. Epub 2016 Mar 12. [PMID 26970755]

(28) Willi TS, Honer WG, Thornton AE, Gicas K, Procyshyn RM, Vila-Rodriguez F, Panenka WJ, Aleksic A, Leonova O, Jones AA, MacEwan GW, Barr AM. Factors affecting severity of positive and negative symptoms of psychosis in a polysubstance using population with psychostimulant dependence. Psychiatry Res. 2016 Jun 30;240:336-42. doi: 10.1016/j.psychres.2016.04.059. Epub 2016 Apr 22. [PMID 27138828]

(29) Wright AD, Jarrett M, Vavasour I, Shahinfard E, Kolind S, van Donkelaar P, Taunton J, Li D, Rauscher A. Myelin water fraction is transiently reduced after a single mild traumatic brain injury – A prospective cohort study in collegiate hockey players. PLoS One. 2016 Feb 25;11(2):e0150215. doi: 10.1371/journal.pone.0150215. eCollection 2016. [PMID 26913900]

2015 | Top

(01) Baronas VA, McGuinness BR, Brigidi GS, Gomm Kolisko RN, Vilin YY, Kim RY, Lynn FC, Bamji SX, Yang R, Kurata HT. Use-dependent activation of neuronal Kv1.2 channel complexes. J Neurosci. 2015 Feb 25;35(8):3515-24. doi: 10.1523/JNEUROSCI.4518-13.2015. [PMID 25716850]

(02) Bjerkefors A, Squair JW, Malik R, Lam T, Chen Z, Carpenter MG. Response to ‘Diagnostic accuracy of common clinical tests for assessing abdominal muscle function after motor-complete spinal cord injury above T6’. Spinal Cord. 2015 Dec;53(12):892. doi: 10.1038/sc.2015.115. Epub 2015 Jul 14. No abstract available. [PMID 26169168]

(03) deBacker J, Hawken ER, Normandeau CP, Jones AA, Di Prospero C, Mechefske E, Gardner Gregory J, Hayton SJ, Dumont ÉC. GluN2B-containing NMDA receptors blockade rescues bidirectional synaptic plasticity in the bed nucleus of the stria terminalis of cocaine self-administering rats. Neuropsychopharmacology. 2015 Jan;40(2):394-405. doi: 10.1038/npp.2014.182. Epub 2014 Jul 18. [PMID 25035084]

(04) Edgcumbe P, Pratt P, Yang GZ, Nguan C, Rohling R. Pico Lantern: Surface reconstruction and augmented reality in laparoscopic surgery using a pick-up laser projector. Med Image Anal. 2015 Oct;25(1):95-102. doi: 10.1016/ Epub 2015 May 7. [PMID 26024818]

(05) Eirew P, Steif A, Khattra J, Ha G, Yap D, Farahani H, Gelmon K, Chia S, Mar C, Wan A, Laks E, Biele J, Shumansky K, Rosner J, McPherson A, Nielsen C, Roth AJ, Lefebvre C, Bashashati A, de Souza C, Siu C, Aniba R, Brimhall J, Oloumi A, Osako T, Bruna A, Sandoval JL, Algara T, Greenwood W, Leung K, Cheng H, Xue H, Wang Y, Lin D, Mungall AJ, Moore R, Zhao Y, Lorette J, Nguyen L, Huntsman D, Eaves CJ, Hansen C, Marra MA, Caldas C, Shah SP, Aparicio S. Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution. Nature. 2015 Feb 19;518(7539):422-6. doi: 10.1038/nature13952. Epub 2014 Nov 26. [PMID 25470049]

(06) Fuller J, Apramian T, Min C. Social Science and Humanities Research in MD-PhD Training. Acad Med. 2015 Oct;90(10):1292. doi: 10.1097/ACM.0000000000000867.[PMID 27002880]

(07) Honer WG, Jones AA, Thornton AE, Barr AM, Procyshyn RM, Vila-Rodriguez F. Response trajectories to clozapine in a secondary analysis of pivotal trials support using treatment response to subtype schizophrenia. Can J Psychiatry. 2015 Mar;60(3 Suppl 2):S19-25. [PMID 25886676]

(08) Jamshidi F, Nielsen TO, Huntsman DG. Cancer genomics: Why rare is valuable. J Mol Med (Berl). 2015 Apr;93(4):369-81. doi: 10.1007/s00109-015-1260-8. Epub 2015 Feb 14. Review. [PMID 25676695]

(09) Johnston CW, Skinnider MA, Wyatt MA, Li X, Ranieri MR, Yang L, Zechel DL, Ma B, Magarvey NA. An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products. Nat Commun. 2015 Sep 28;6:8421. doi: 10.1038/ncomms9421. PMID 26412281]

(10) Jones AA, Vila-Rodriguez F, Leonova O, Langheimer V, Lang DJ, Barr AM, Procyshyn RM, Smith GN, Schultz K, Buchanan T, Krausz M, Montaner JS, MacEwan GW, Rauscher A, Panenka WJ, Thornton AE, Honer WG. Mortality from treatable illnesses in marginally housed adults: a prospective cohort study. BMJ Open. 2015 Aug 21;5(8):e008876. doi: 10.1136/bmjopen-2015-008876. [PMID 26297373]

(11) Kulasegaram K, Min C, Howey E, Neville A, Woods N, Dore K, Norman G. The mediating effect of context variation in mixed practice for transfer of basic science. Adv Health Sci Educ Theory Pract. 2015 Oct;20(4):953-68. doi: 10.1007/s10459-014-9574-9. Epub 2014 Dec 12. [PMID 25524224]

(12) Laskin J, Jones S, Aparicio S, Chia S, Ch’ng C, Deyell R, Eirew P, Fok A, Gelmon K, Ho C, Huntsman D, Jones M, Kasaian K, Karsan A, Leelakumari S, Li Y, Lim H, Ma Y, Mar C, Martin M, Moore R, Mungall A, Mungall K, Pleasance E, Rassekh SR, Renouf D, Shen Y, Schein J, Schrader K, Sun S, Tinker A, Zhao E, Yip S, Marra MA. Lessons learned from the application of whole-genome analysis to the treatment of patients with advanced cancers. Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000570. doi: 10.1101/mcs.a000570. [PMID 27148575]

(13) Mathelier A, Lefebvre C, Zhang AW, Arenillas DJ, Ding J, Wasserman WW, Shah SP. Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas. Genome Biol. 2015 Apr 23;16:84. doi: 10.1186/s13059-015-0648-7. [PMID 25903198]

(14) Nguyen LV, Pellacani D, Lefort S, Kannan N, Osako T, Makarem M, Cox CL, Kennedy W, Beer P, Carles A, Moksa M, Bilenky M, Balani S, Babovic S, Sun I, Rosin M, Aparicio S, Hirst M, Eaves CJ. Barcoding reveals complex clonal dynamics of de novo transformed human mammary cells. Nature. 2015 Dec 10;528(7581):267-71. doi: 10.1038/nature15742. Epub 2015 Dec 2. [PMID 26633636]

(15) Pon JR, Marra MA. Driver and passenger mutations in cancer. Annu Rev Pathol. 2015;10:25-50. doi: 10.1146/annurev-pathol-012414-040312. Epub 2014 Oct 17. Review. [PMID 25340638]

(16) Pon JR, Wong J, Saberi S, Alder O, Moksa M, Grace Cheng SW, Morin GB, Hoodless PA, Hirst M, Marra MA. MEF2B mutations in non-Hodgkin lymphoma dysregulate cell migration by decreasing MEF2B target gene activation. Nat Commun. 2015 Aug 6;6:7953. doi: 10.1038/ncomms8953. [PMID 26245647]

(17) Skinnider MA, Dejong CA, Rees PN, Johnston CW, Li H, Webster AL, Wyatt MA, Magarvey NA. Genomes to natural products PRediction Informatics for Secondary Metabolomes (PRISM). Nucleic Acids Res. 2015 Nov 16;43(20):9645-62. doi: 10.1093/nar/gkv1012. Epub 2015 Oct 5. [PMID 26442528]

(18) Squair JW, le Nobel G, Noonan VK, Raina G, Krassioukov AV. Assessment of clinical adherence to the international autonomic standards following spinal cord injury. Spinal Cord. 2015 Sep;53(9):668-72. doi: 10.1038/sc.2015.54. Epub 2015 Mar 31. [PMID 25823802]

(19) Twa DD, Squair JW, Skinnider MA, Ji JX. The Canadian clinician-scientist training program must be reinstated. J Clin Invest. 2015 Nov 3;125(12):4317-9. doi: 10.1172/JCI85194. Review. [PMID 26529253]

(20) van den Berg W, Brittain K, Mercer G, Peacock D, Stinson K, Janson H, Dubula V. Improving men’s participation in preventing mother-to-child transmission of HIV as a maternal, neonatal, and child health priority in South Africa. PLoS Med. 2015 May 11;12(5):e1001836. doi: 10.1371/journal.pmed.1001836. eCollection 2015 May. [PMID 25961291]

(21) Westwell-Roper CY, Chehroudi CA, Denroche HC, Courtade JA, Ehses JA, Verchere CB. IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice. Diabetologia. 2015 Mar;58(3):575-85. doi: 10.1007/s00125-014-3447-x. Epub 2014 Dec 10. [PMID 25491100]

(22) Woodsworth DJ, Dunsing V, Coombs D. Design parameters for granzyme-mediated cytotoxic lymphocyte target-cell killing and specificity. Biophys J. 2015 Aug 4;109(3):477-88. doi: 10.1016/j.bpj.2015.06.045. [PMID 26244730]

(24) Yang L, Ibrahim A, Johnston CW, Skinnider MA, Ma B, Magarvey NA. Exploration of nonribosomal peptide families with an automated informatic search algorithm. Chem Biol. 2015 Sep 17;22(9):1259-69. doi: 10.1016/j.chembiol.2015.08.008. Epub 2015 Sep 10. [PMID 26364933]

(24) Zhao EY, Zhou TE, Benesch MG, Dey A, Liu P, Steadman PE, Zaslavsky K, Schneider R, Kuzyk A. Scientific overview: CSCI-CITAC annual general meeting and Young Investigators’ Forum 2015. Clin Invest Med. 2016 Oct 14;39(5):E142-E149. [PMID 27805897]

2014 | Top

(01) Baronas VA, Kurata HT. Inward rectifiers and their regulation by endogenous polyamines. Front Physiol. 2014 Aug 27;5:325. doi: 10.3389/fphys.2014.00325. eCollection 2014. Review. [PMID 25221519]

(02) Edgcumbe P, Pratt P, Yang GZ, Nguan C, Rohling R. Pico Lantern: a pick-up projector for augmented reality in laparoscopic surgery. Med Image Comput Comput Assist Interv. 2014;17(Pt 1):432-9. [PMID 25333147]

(03) Jamshidi F, Pleasance E, Li Y, Shen Y, Kasaian K, Corbett R, Eirew P, Lum A, Pandoh P, Zhao Y, Schein JE, Moore RA, Rassekh R, Huntsman DG, Knowling M, Lim H, Renouf DJ, Jones SJ, Marra MA, Nielsen TO, Laskin J, Yip S. Diagnostic value of next-generation sequencing in an unusual sphenoid tumor. Oncologist. 2014 Jun;19(6):623-30. doi: 10.1634/theoncologist.2013-0390. Epub 2014 May 7. [PMID 24807916]

(04) Jing G, Westwell-Roper C, Chen J, Xu G, Verchere CB, Shalev A. Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. J Biol Chem. 2014 Apr 25;289(17):11807-15. doi: 10.1074/jbc.M113.525022. Epub 2014 Mar 13. [PMID 24627476]

(05) Kannan N, Nguyen LV, Eaves CJ. Integrin β3 links therapy resistance and cancer stem cell properties. Nat Cell Biol. 2014 May;16(5):397-9. [PMID 24914436]

(06) Kannan N, Nguyen LV, Makarem M, Dong Y, Shih K, Eirew P, Raouf A, Emerman JT, Eaves CJ. Glutathione-dependent and -independent oxidative stress-control mechanisms distinguish normal human mammary epithelial cell subsets. Proc Natl Acad Sci U S A. 2014 May 27;111(21):7789-94. doi: 10.1073/pnas.1403813111. Epub 2014 May 12. [PMID 24821780]

(07) Krawczyk M, deBacker J, Mason X, Jones AA, Dumont EC. Dopamine decreases NMDA currents in the oval bed nucleus of the stria terminalis of cocaine self-administering rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Jun 3;51:83-8. doi: 10.1016/j.pnpbp.2014.01.011. Epub 2014 Jan 26. [PMID 24472317]

(08) Mathelier A, Zhao X, Zhang AW, Parcy F, Worsley-Hunt R, Arenillas DJ, Buchman S, Chen CY, Chou A, Ienasescu H, Lim J, Shyr C, Tan G, Zhou M, Lenhard B, Sandelin A, Wasserman WW. JASPAR 2014: an extensively expanded and updated open-access database of transcription factor binding profiles. Nucleic Acids Res. 2014 Jan;42(Database issue):D142-7. doi: 10.1093/nar/gkt997. Epub 2013 Nov 4. [PMID 24194598]

(09) Nackiewicz D, Dan M, He W, Kim R, Salmi A, Rütti S, Westwell-Roper C, Cunningham A, Speck M, Schuster-Klein C, Guardiola B, Maedler K, Ehses JA. TLR2/6 and TLR4-activated macrophages contribute to islet inflammation and impair beta cell insulin gene expression via IL-1 and IL-6. Diabetologia. 2014 Aug;57(8):1645-54. doi: 10.1007/s00125-014-3249-1. Epub 2014 May 12. [PMID 24816367]

(10) Nguyen LV, Cox CL, Eirew P, Knapp DJ, Pellacani D, Kannan N, Carles A, Moksa M, Balani S, Shah S, Hirst M, Aparicio S, Eaves CJ. DNA barcoding reveals diverse growth kinetics of human breast tumour subclones in serially passaged xenografts. Nat Commun. 2014 Dec 23;5:5871. doi: 10.1038/ncomms6871. [PMID 25532760]

(11) Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AMS, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, Aparicio S, Eaves CJ, Hirst M. Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells. Cell Stem Cell. 2014 Feb 6;14(2):253-63. doi: 10.1016/j.stem.2013.12.011. Epub 2014 Jan 16. [PMID 24440600]

(12) Potter KJ, Westwell-Roper CY, Klimek-Abercrombie AM, Warnock GL, Verchere CB. Death and dysfunction of transplanted β-cells: Lessons learned from Type 2 diabetes? Diabetes. 2014 Jan;63(1):12-9. doi: 10.2337/db12-0364. [PMID 24357689]

(13) Westwell-Roper C, Ehses JA. Is there a role for the adaptive immune system in pancreatic beta cell failure in type 2 diabetes? Diabetologia. 2014 Mar;57(3):447-50. doi: 10.1007/s00125-013-3151-2. Epub 2013 Dec 21. [PMID 24362729]

(14) Westwell-Roper CY, Ehses JA, Verchere CB. Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and beta cell dysfunction. Diabetes. 2014 May;63(5):1698-711. doi: 10.2337/db13-0863. Epub 2013 Nov 12. [PMID 24222351]

(15) Westwell-Roper C, Nackiewicz D, Dan M, Ehses JA. Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes. Immunol Cell Biol. 2014 Apr;92(4):314-23. doi: 10.1038/icb.2014.4. Epub 2014 Feb 4. [PMID 24492799]

(16) Wohrer S, Knapp DJ, Copley MR, Benz C, Kent DG, Rowe K, Babovic S, Mader H, Oostendorp RA, Eaves CJ. Distinct stromal cell factor combinations can separately control hematopoietic stem cell survival, proliferation, and self-renewal. Cell Rep. 2014 Jun 26;7(6):1956-67. doi: 10.1016/j.celrep.2014.05.014. Epub 2014 Jun 6. [PMID 24910437]

2013 | Top

(01) Cheung AM, Nguyen LV, Carles A, Beer P, Miller PH, Knapp DJHF, Dhillon K, Hirst M, Eaves CJ. Analysis of the clonal growth and differentiation dynamics of primitive barcoded human cord blood cells in NSG mice.  Blood. 2013 Oct 31;122(18):3129-37. doi: 10.1182/blood-2013-06-508432. Epub 2013 Sep 12. [PMID 24030380]

(02) Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ. The Lin28b–let-7–Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nat Cell Biol. 2013 Aug;15(8):916-25. doi: 10.1038/ncb2783. Epub 2013 Jun 30. [PMID 23811688]

(03) Copley MR, Eaves CJ. Developmental changes in hematopoietic stem cell properties. Exp Mol Med. 2013 Nov 15;45:e55. doi: 10.1038/emm.2013.98. [PMID 24232254]

(04) Crabtree A, Mercer G, Horan R, Grant S, Tan T, Buxton JA. A qualitative study of the perceived effects of blue lights in washrooms on people who use injection drugs. Harm Reduct J. 2013 Oct 8;10:22. doi: 10.1186/1477-7517-10-22. [PMID 24099145]

(05) Jones AA, Vila-Rodriguez F, Panenka WJ, Leonova O, Strehlau V, Lang DJ, Thornton AE, Wong H, Barr AM, Procyshyn RM, Smith GN, Buchanan T, Krajden M, Krausz M, Montaner JS, Macewan GW, Nutt DJ, Honer WG. Personalized risk assessment of drug-related harm is associated with health outcomes. PLoS One. 2013 Nov 6;8(11):e79754. doi: 10.1371/journal.pone.0079754. eCollection 2013. [PMID 24223192]

(06) Ma HK, Min C, Neville A, Eva K. How good is good? Students and assessors’ perceptions of qualitative markers of performance. Teach Learn Med. 2013;25(1):15-23. doi: 10.1080/10401334.2012.741545. [PMID 23330890]

(07) Makarem M, Kannan N, Nguyen LV, Knapp DJ, Balani S, Prater MD, Stingl J, Raouf A, Nemirovsky O, Eirew P, Eaves CJ. Developmental changes in the in vitro activated regenerative activity of primitive mammary epithelial cells. PLoS Biol. 2013;11(8):e1001630. doi: 10.1371/journal.pbio.1001630. Epub 2013 Aug 13. [PMID 23966837]

(08) Mohajerani MH, Chan AW, Mohsenvand M, Ledue J, Liu R, McVea DA, Boyd JD, Wang YT, Reimers M, Murphy TH. Spontaneous cortical activity alternates between motifs defined by regional axonal projections. Nat Neurosci. 2013 Oct;16(10):1426-35. doi: 10.1038/nn.3499. Epub 2013 Aug 25. [PMID 23974708]

(09) Morin RD, Mungall K, Pleasance E, Mungall AJ, Goya R, Huff R, Scott DW, Ding J, Roth A, Chiu R, Corbett RD, Chan FC, Mendez-Lago M, Trinh DL, Bolger-Munro M, Taylor G, Hadj Khodabakhshi A, Ben-Neriah S, Pon J, Meissner B, Woolcock B, Farnoud N, Rogic S, Lim E, Johnson NA, Shah S, Jones S, Steidl C, Holt R, Birol I, Moore R, Connors JM, Gascoyne RD, Marra MA. Mutational and structural analysis of diffuse large B-cell lymphoma using whole genome sequencing. Blood. 2013 Aug 15;122(7):1256-65. doi: 10.1182/blood-2013-02-483727. Epub 2013 May 22. [PMID 23699601]

(10) Potter KJ, Creighton S, Armstrong L, Eydoux P, Duncan W, Penny DJ, Fan Y, Gibson WT. The c.7409G>A (p.Cys2470Tyr) Variant of FBN1: Phenotypic variability across three generations. Mol Syndromol. 2013 Mar;4(3):125-35. doi: 10.1159/000347163. Epub 2013 Feb 28. [PMID 23653584]

(11) Sabatini PV, Krentz NA, Zarrouki B, Westwell-Roper C, Nian C, Uy RA, Shapiro AM, Poitout V, Lynn FC. Npas4 is a novel activity-regulated cytoprotective factor in pancreatic β-Cells. Diabetes. 2013 Aug;62(8):2808-20. doi: 10.2337/db12-1527. Epub 2013 May 8. [PMID 23656887]

(12) Sutton LM, Sanders SS, Butland SL, Singaraja RR, Franciosi S, Southwell AL, Doty CN, Schmidt ME, Mui KK, Kovalik V, Young FB, Zhang W, Hayden MR. Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease. Hum Mol Genet. 2013 Feb 1;22(3):452-65. doi: 10.1093/hmg/dds441. Epub 2012 Oct 16. [PMID 23077216]

(13) Westwell-Roper C, Dunne A, Kim ML, Verchere CB, Masters SL. Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP. Methods Mol Biol. 2013;1040:9-18. doi: 10.1007/978-1-62703-523-1_2. [PMID 23852593]

(14) Woodsworth DJ, Castellarin M, Holt RA. Sequence analysis of T-cell repertoires in health and disease. Genome Med. 2013 Oct 30;5(10):98. doi: 10.1186/gm502. eCollection 2013. [PMID 24172704]

2012 | Top

(01) Astanehe A, Finkbeiner MR, Krzywinski M, Fotovati A, Dhillon J, Berquin IM, Mills GB, Marra MA, Dunn SE. MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition. Oncogene 31(41):4434-46. 2012. [PMID 22249268]

(02) Benz C, Copley MR, Kent DG, Wohrer S, Cortes A, Aghaeepour N, Ma E, Mader H, Rowe K, Day C, Treloar D, Brinkman RR, Eaves CJ. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell 10(3):273-83. 2012. [PMID 22385655]

(03) Berkhout SG. Relational autonomy on the cutting edge. Am J Bioethics 12(7):59-61. 2012. [PMID 22694041]

(04) Copley MR, Beer PA, Eaves CJ. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell 10(6):690-7. 2012. [PMID 22704509]

(05) Eadie BD, Cushman J, Kannangara TS, Fanselow MS, Christie BR. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus 22(2):241-54.2012. [PMID 21049485]

(06) Henry B, Crabtree A, Roth D, Blackman D, Morshed M. Lyme disease: knowledge, beliefs, and practices of physicians in a low-endemic area. Can Fam Physician 58(5):e289-95. 2012. [PMID 22734172]

(07) Kozoriz MG, Grebenyuk J, Andrews G, Forster BB. Evaluating bone marrow oedema patterns in musculoskeletal injury. Br J Sports Med 46(13):946-53. 2012. [PMID 22496099]

(08) Kruit JK, Wijesekara N, Westwell-Roper C, Vanmierlo T, de Haan W, Bhattacharjee A, Tang R, Wellington CL, Lütjohann D, Johnson JD, Brunham LR, Verchere CB, Hayden MR. Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function. Diabetes 61(3):659-64. 2012. [PMID 22315310]

(09) Kulasegaram K, Min C, Ames K, Howey E, Neville A, Norman G. The effect of conceptual and contextual familiarity on transfer performance. Adv Health Sci Educ Theory Pract 17(4):489-99. 2012 [PMID 21959956]

(10) McVea DA, Mohajerani MH, Murphy TH. Voltage-sensitive dye imaging reveals dynamic spatiotemporal properties of cortical activity after spontaneous muscle twitches in the newborn rat. J Neurosci 32(32):10982-94. 2012. [PMID 22875932]

(11) Montane J, Klimek-Abercrombie A, Potter KJ, Westwell-Roper C, Bruce Verchere C. Metabolic stress, IAPP and islet amyloid. Diabetes Obes Metab 14 Suppl 3:68-77. 2012. [PMID 22928566]

(12) Nguyen LV, Vanner R, Dirks P, Eaves CJ. Cancer stem cells: an evolving concept. Nat Review Cancer 12(2):133-43. 2012. [full text]

(13) Wright AD, Laing AC. The influence of headform orientation and flooring systems on impact dynamics during simulated fall-related head impacts. Med Eng Phys 34(8):1071-8. 2012. [PMID 22172523]

(14) Young FB, Butland SL, Sanders SS, Sutton LM, Hayden MR. Putting proteins in their place: palmitoylation in Huntington disease and other neuropsychiatric diseases. Prog Neurobiol 97(2):220-38. 2012. [PMID 22155432]

(15) Young FB, Franciosi S, Spreeuw A, Deng Y, Sanders S, Tam NC, Huang K, Singaraja RR, Zhang W, Bissada N, Kay C, Hayden MR. Low levels of human HIP14 are sufficient to rescue neuropathological, behavioural, and enzymatic defects due to loss of murine HIP14 in Hip14-/- mice. PLoS One 7(5):e36315. 2012. [PMID 22649491]

2011 | Top

(01) Bailey J, Potter KJ, Verchere CB, Edelstein-Keshet L, Coombs D. Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling. Phys Biol 8(6):066009. 2011. [full text]

(02) Buxton JA, Henry B, Crabtree A, Waheed A, Coulthart M. Using qualitative methods to investigate risk perception of Canadian medical laboratory workers in relation to current prion disease infection control policies. J Toxicol Environ Health A. 74(2-4):241-7. 2011. [PMID 21218349]

(03) Grad LI, Guest WC, Yanai A, Pokrishevsky E, O’Neill MA, Gibbs E, Semenchenko V, Yousefi M, Wishart DS, Plotkin SS, Cashman NR. Intermolecular transmission of superoxide dismutase 1 misfolding in living cells. Proc Natl Acad Sci U S A 27;108(39):16398-403. 2011. [PMID 21930926]

(04) Guest WC, Cashman NR, Plotkin SS. A theory for the anisotropic and inhomogeneous dielectric properties of proteins. Phys Chem Chem Phys 13(13):6286-95. 2011. [PMID 21359369]

(05) Guest WC, Plotkin SS, Cashman NR. Toward a mechanism of prion misfolding and structural models of PrP(Sc): current knowledge and future directions. J Toxicol Environ Health A. 74(2-4):154-60. 2011. Review. [PMID 21218344]

(06) Guest WC, Silverman JM, Pokrishevsky E, O’Neill MA, Grad LI, Cashman NR. Generalization of the prion hypothesis to other neurodegenerative diseases: an imperfect fit. J Toxicol Environ Health A. 74(22-24):1433-59. 2011. Review. [PMID 22043906]

(07) Huang K, Sanders SS, Kang R, Carroll JB, Sutton L, Wan J, Singaraja R, Young FB, Liu L, El-Husseini A, Davis NG, Hayden MR. Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14. Hum Mol Genet 20(17):3356-65. 2011. [PMID 21636527]

(08) Kashefian Naieni A, Yaghoobi P, Woodsworth DJ, Nojeh A. Structural deformations and current oscillations in armchair-carbon nanotube cross devices: a theoretical study. J Phys D: Appl Phys 44:085402(1-7). 2011. [full text]

(09) Lecault V, Vaninsberghe M, Sekulovic S, Knapp DJ, Wohrer S, Bowden W, Viel F, McLaughlin T, Jarandehei A, Miller M, Falconnet D, White AK, Kent DG, Copley MR, Taghipour F, Eaves CJ, Humphries RK, Piret JM, Hansen CL. High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays. Nat Methods 8(7):581-6. 2011. [PMID 21602799]

(10) Singaraja RR, Huang K, Sanders SS, Milnerwood AJ, Hines R, Lerch JP, Franciosi S, Drisdel RC, Vaid K, Young FB, Doty C, Wan J, Bissada N, Henkelman RM, Green WN, Davis NG, Raymond LA, Hayden MR. Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum Mol Genet 20(20):3899-909. 2011. [PMID 21775500]

(11) Westwell-Roper C, Dai DL, Soukhatcheva G, Potter KJ, van Rooijen N, Ehses JA, Verchere CB. IL-1 Blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol 187(5):2755-65. 2011. [PMID 21813778]

2010 | Top

(01) Dhillon J, Astanehe A, Lee C, Fotovati A, Hu K, Dunn SE. The expression of activated Y-box binding protein-1 serine 102 mediates trastuzumab resistance in breast cancer cells by increasing CD44+ cells. Oncogene 29(47):6294-300. 2010. [PMID 20802512]

(02) Eadie BD, Cushman J, Kannangara TS, Fanselow MS, Christie BR. NMDA receptor hypofunction in the dentate gyrus and impaired context discrimination in adult Fmr1 knockout mice. Hippocampus Nov 3. 2010. [PMID 21049485]

(03) Froger N, Orellana JA, Calvo CF, Amigou E, Kozoriz MG, Naus CC, Sáez JC, Giaume C. Inhibition of cytokine-induced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci 45(1):37-46. 2010. [PMID 20684043]

(04) Guest WC, Cashman NR, Plotkin SS. Electrostatics in the stability and misfolding of the prion protein: salt bridges, self energy, and solvation. Biochem Cell Biol 88(2):371-81. 2010. [PMID 20453937]

(05) Heslop CL, Frohlich JJ, Hill JS. Myeloperoxidase and C-reactive protein have combined utility for long-term prediction of cardiovascular mortality after coronary angiography. J Am Coll Cardiol 55(11):1102-9. 2010. [PMID 20223364]

(06) Joe AW, Yi L, Natarajan A, Le Grand F, So L, Wang J, Rudnicki MA, Rossi FM. Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis. Nat Cell Biol 12(2):153-63. 2010. [PMID 20081841]

(07) Kozoriz MG, Bechberger JF, Bechberger GR, Suen MW, Moreno AP, Maass K, Willecke K, Naus CC. The connexin43 C-terminal region mediates neuroprotection during stroke. J Neuropathol Exp Neurol 69(2):196-206. 2010. [PMID 20084014]

(08) Kozoriz MG, Church J, Ozog MA, Naus CC, Krebs C. Temporary sequestration of potassium by mitochondria in astrocytes. J Biol Chem 285(41):31107-19. 2010. [PMID 20667836]

(09) Law JH, Li Y, To K, Wang M, Astanehe A, Lambie K, Dhillon J, Jones SJ, Gleave ME, Eaves CJ, Dunn SE. Molecular decoy to the Y-box binding protein-1 suppresses the growth of breast and prostate cancer cells whilst sparing normal cell viability. PLoS ONE 5(9):e12661. 2010. [PMID 20844753]

(10) Meng F, Abedini A, Plesner A, Middleton CT, Potter KJ, Zanni MT, Verchere CB, Raleigh DP. The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation. J Mol Biol 400(3):555-66. 2010. [PMID 20452363]

(11) Mohajerani MH, McVea DA, Fingas M, Murphy TH. Mirrored bilateral slow-wave cortical activity within local circuits revealed by fast bihemispheric voltage-sensitive dye imaging in anesthetized and awake mice. J Neurosci 30(10):3745-51. 2010. [PMID 20220008]

(12) Petriv OI, Kuchenbauer F, Delaney AD, Lecault V, White A, Kent D, Marmolejo L, Heuser M, Berg T, Copley M, Ruschmann J, Sekulovic S, Benz C, Kuroda E, Ho V, Antignano F, Halim T, Giambra V, Krystal G, Takei CJ, Weng AP, Piret J, Eaves C, Marra MA, Humphries RK, Hansen CL. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA. 107(35):15443-8. 2010. [PMID 20702766]

(13) Potter KJ, Abedini A, Marek P, Klimek AM, Butterworth S, Driscoll M, Baker R, Nilsson MR, Warnock GL, Oberholzer J, Bertera S, Trucco M, Korbutt GS, Fraser PE, Raleigh DP, Verchere CB. Islet amyloid deposition limits the viability of human islet grafts but not porcine islet grafts. Proc Natl Acad Sci 107(9):4305-10. 2010. [PMID 20160085]

(14) Rezai N, Deisher TA, Heine HL, Wang X, Corbel SY, Leung J, Kerjner A, Rossi FM, Podor TJ, McManus BM. Effects of granulocyte-colony stimulating factor on bone marrow-derived progenitor cells in murine cardiac transplantation. Cardiovasc Path 19(1):36-47. 2010. [PMID 19144547]

(15) Sekirov I, Gill N, Jogova M, Tam N, Robertson M, de Llanos R, Li Y, Finlay BB. Salmonella SPI-1-mediated neutrophil recruitment during enteric colitis is associated with reduction and alteration in intestinal microbiota. Gut Microbes 1(1):30-41. 2010. [PMID 21327114]

(16) Sekirov I, Russell SL, Antunes LC, Finlay BB. Gut microbiota in health and disease. Physiol Rev 90(3):859-904. 2010. Review. [PMID 20664075]

(17) To K, Fotovati A, Reipas KM, Law JH, Hu K, Wang J, Astanehe A, Davies AH, Lee L, Stratford AL, Raouf A, Johnson P, Berquin IM, Royer HD, Eaves CJ, Dunn SE. Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance. Cancer Res 70(7):2840-51. 2010. [PMID 20332234]

(18) Zraika S, Hull RL, Verchere CB, Clark A, Potter KJ, Fraser PE, Raleigh DP, Kahn SE. Toxic oligomers and islet beta cell death: guilty by association or convicted by circumstantial evidence? Diabetologia 53(6):1046-56. 2010. [PMID 20182863]

2009 | Top

(01) Astanehe A, Finkbeiner MR, Hojabrpour P, To K, Fotovati A, Shadeo A, Stratford AL, Lam WL, Berquin IM, Duronio V, Dunn SE. The transcriptional induction of PIK3CA in tumor cells is dependent on the oncoprotein Y-box binding protein-1. Oncogene 28(25):2406-18. 2009. [PMID 19430491]

(02) Dahlhaus R, Hines RM, Eadie BD, Kannangara TS, Hines DJ, Brown CE, Christie BR, El-Husseini A. Overexpression of the cell adhesion protein neuroligin-1 induces learning deficits and impairs synaptic plasticity by altering the ratio of excitation to inhibition in the hippocampus. Hippocampus 2009 May 12. [PMID 19437420]

(03) Donelan JM, McVea DA, Pearson KG. Force regulation of ankle extensor muscle activity in freely walking cats. J Neurophysiol 101(1):360-371. 2009. [PMID 19019974]

(04) Eadie BD, Zhang WN, Boehme F, Gil-Mohapel J, Kainer L, Simpson JM, Christie BR. Fmr1 knockout mice show reduced anxiety and alterations in neurogenesis that are specific to the ventral dentate gyrus. Neurobiol Dis 36(2):361-73. 2009. [PMID 19666116]

(05) Finkbeiner MR, Astanehe A, To K, Fotovati A, Davies AH, Zhao Y, Jiang H, Stratford AL, Shadeo A, Boccaccio C, Comoglio P, Mertens PR, Eirew P, Raouf A, Eaves CJ, Dunn SE. Profiling YB-1 target genes uncovers a new mechanism for MET receptor regulation in normal and malignant human mammary cells. Oncogene 28(11):1421-31. 2009. [PMID 19151767]

(06) Heslop C, Miller GE, Hill J. Neighbourhood socioeconomics status predicts non-cardiovascular mortality in cardiac patients with access to universal health care. PLoS ONE 4(1):e4120. 2009. [full text]

(07) Hutton MJ, Westwell-Roper C, Soukhatcheva G, Plesner A, Dutz JP, Verchere CB. Islet allograft rejection is independent of toll-like receptor signaling in mice. Transplantation 88(9):1075-80. 2009. [PMID 19898202]

(08) Joe AW, Y Li, Even Y, Vogl AW, Rossi FMV. Depot-specific differences in adipogenic progenitor abundance and their proliferative response to high fat diet. Stem Cells 27(10):2563-70. 2009. [PMID 19658193]

(09) Johnson JD, Ao Z, Ao P, Li H, Dai L, He Z, Tee M, Potter KJ, Klimek AM, Meloche RM, Thompson DM, Verchere CB, Warnock GL. Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplant Apr 10. pii: CT-1977. 2009. [PMID 19500470]

(10) Kent DG, Copley MR, Benz C, Wöhrer S, Dykstra BJ, Ma E, Cheyne J, Zhao Y, Bowie MB, Zhao Y, Gasparetto M, Delaney A, Smith C, Marra M, Eaves CJ. Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential. Blood 113(25):6342-50. 2009. [PMID 19377048]

(11) Li L, Guest W, Huang A, Plotkin SS, Cashman NR. Immunological mimicry of PrPC-PrPSc interactions: antibody-induced PrP misfolding. Protein Eng Des Sel 22(8):523-9. 2009. [PMID 19602568]

(12) McVea DA, Pearson KG. Object avoidance during locomotion. Adv Exp Med Biol. 629: 293-315. 2009. [PMID 19227506]

(13) Parkinson PF, Kannangara TS, Eadie BD, Burgess BL, Wellington CL, Christie BR. Cognition, learning behaviour and hippocampal synaptic plasticity are not disrupted in mice over-expressing the cholesterol transporter ABCG1. Lipids Health Dis Feb 24 8:5. 2009. [PMID 19239689]

(14) Potter KJ, Scrocchi LA, Warnock GL, Ao Z, Younker MA, Rosenberg L, Lipsett M, Verchere CB, Fraser PE. Amyloid inhibitors enhance survival of cultured human islets. Biochim Biophys Acta. 1790(6):566-74. 2009. [PMID 19264107]

(15) Sekirov I, Finlay BB. The role of the intestinal microbiota in enteric infection. J Physiol 587(Pt 17):4159-67. 2009. [PMID 19491248]

(16) Zarzeczny A, Scott C, Hyun I, Bennett J, Chandler J, Charge S, Heine H, Isasi R, Kazuto K, Lovell-Badge R, McNagny K, Pei D, Rossant J, Surani A, Taylor P, Ogbogu U, Caulfield T. iPS Cells: mapping the policy issues. Cell 139(6):1032-7. 2009. [PMID 20005794]

2008 | Top

(01) Astanehe A, Arenillas D, Wasserman WW, Leung PC, Dunn SE, Davies BR, Mills GB, Auersperg N. Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer. J Cell Sci 121(5):664-74. 2008. [PMID 18270270]

(02) Berkhout SG. Buns in the oven: Objectification, surrogacy, and women’s autonomy. Social Theory and Practice 34:1 2008. [full text]

(03) Brunham LR, Kruit JK, Verchere CB, Hayden MR. Cholesterol in islet dysfunction and type 2 diabetes. J Clin Invest 118(2):403-8. 2008. [PMID 18246189]

(04) Christie BR, Eadie BD, Kannangara TS, Robillard JM, Shin J, Titterness AK. Exercising our brains: how physical activity impacts synaptic plasticity in the dentate gyrus. Neuromolecular Med 10(2):47-58. 2008. [PMID 18535925]

(05) Hu Q, Coburn B, Deng W, Li Y, Shi X, Lan Q, Wang B, Coombes BK, Finlay BB. Salmonella enterica serovar Senftenberg human clinical isolates lacking SPI-1. J Clin Microbiol 46(4):1330-6. 2008. [PMID 18272702]

(06) Kent D, Copley M, Benz C, Dykstra B, Bowie M, Eaves C. Regulation of hematopoietic stem cells by the steel factor/KIT signaling pathway. Clin Cancer Res. 14(7):1926-30. 2009. [PMID 18381929]

(07) Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Can Res 68:8661-6. 2008. [full text]

(08) Meng F, Marek P, Potter KJ, Verchere CB, Raleigh DP. Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death. Biochem 47(22):6016-24. 2008. [PMID 18457428]

(09) Sekirov I, Tam NM, Jogova M, Robertson ML, Li Y, Lupp C, Finlay BB. Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection. Infect Immun 76(10):4726-36. 2008. [PMID 18678663]

(10) Young FB. A life without pain? Hedonists take note. Clin Genet. 73(1):31-3. 2008. [PMID 18070140]

(11) Young FB. When adaptive processes go awry: gain-of-function in SCN9A. Clin Genet 73(1):34-6. 2008. [PMID 18070139]

2007 | Top

(01) Asper DJ, Sekirov I, Finlay BB, Rogan D, Potter AA. Cross reactivity of enterohemorrhagic Escherichia coli O157:H7-specific sera with non-O157 serotypes. Vaccine 25(49):8262-9. 2007. [PMID 17980466]

(02) Beyea MM, Heslop CL, Sawyez CG, Edwards JY, Markle JG, Hegele RA, Huff MW. Selective up-regulation of LXR-regulated genes ABCA1, ABCG1 and APOE in macrophages through increased endogenous synthesis of 24(S), 25-epoxycholesterol. J Biol Chem 282(8):5207-16. 2007. [PMID 17186944]

(03) Brunham LR, Kruit JK, Pape TD, Timmins JM, Reuwer AQ, Vasanji Z, Marsh BJ, Rodrigues B, Johnson JD, Parks JS, Verchere CB, Hayden MR. Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med 13(3):340-7. 2007. [PMID 17322896]

(04) Coburn B, Grassl GA, Finlay BB. Salmonella, the host and disease: a brief review. Immunol Cell Biol 85(2):112-8. 2007. [PMID 17146467]

(05) Coburn B, Sekirov I, Finlay BB. Type III Secretion Systems and Disease. Clin Microbiol Rev 20(4):535-49. 2007. [PMID 17934073]

(06) Lupp C, Robertson ML, Wickham ME, Sekirov I, Champion OL, Gaynor EC, Finlay BB. Host-mediated inflammation disrupts the intestinal microbiota and promotes the overgrowth of Enterobacteriaceae. Cell Host Microbe 2(3):204. 2007. [PMID 18030708]

(07) Sly LM, Ho V, Antignano F, Ruschmann J, Hamilton M, Lam V, Rauh MJ, Krystal G. The role of SHIP in macrophages. Front Biosci 12:2836-48. 2007. Review. [PMID 17485263]

(08) Stratford AL, Habibi G, Astanehe A, Jiang H, Hu K, Park E, Shadeo A, Buys TP, Lam W, Pugh T, Marra M, Nielsen TO, Klinge U, Mertens PR, Aparicio S, Dunn SE. Epidermal growth factor receptor (EGFR) is transcriptionally induced by the Y-box binding protein-1 (YB-1) and can be inhibited with Iressa in basal-like breast cancer providing a potential target for therapy. Breast Cancer Res 9(5):R61. 2007. [PMID 17875215]

(09) Wickham ME, Lupp C, Vazquez A, Mascarenhas M, Coburn B, Coombes BK, Karmali MA, Puente JL, Deng W, Brett Finlay B. Citrobacter rodentium virulence in mice associates with bacterial load and the type III effector NleE. Microbes Infect 9(3):400-7. 2007. [PMID 17317262]

(10) Wu J, Stratford A, Astanehe A, Dunn S. YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression. Trans Oncogen 2007; 2:49-65. [PubMed not available]

2006 | Top

(01) Arikawa E, Cheung C, Sekirov I, Battell ML, Yuen VG, McNeill JH. Effects of endothelin receptor blockade on hypervasoreactivity in streptozotocin-diabetic rats: vessel-specific involvement of thromboxane A2. Can J Physiol Pharmacol 84(8-9):823-33. 2006. [PMID 17111027]

(02) Bertram J, Peacock JW, Tan C, Mui AL, Chung SW, Gleave ME, Dedhar S, Cox ME, Ong CJ. Inhibition of the phosphatidylinositol 3′-kinase pathway promotes autocrine Fas-induced death of phosphatase and tensin homologue-deficient prostate cancer cells. Cancer Res 66(9):4781-8. 2006. [PMID 16651432]

(03) Brunham LR, Kruit JK, Iqbal J, Fievet C, Timmins JM, Pape TD, Coburn BA, Bissada N, Staels B, Groen AK, Hussain MM, Parks JS, Kuipers F, Hayden MR. Intestinal ABCA1 directly contributes to HDL biogenesis in vivo. J Clin Invest 116(4):1052-62. 2006. [PMID 16543947]

(04) Brunham LR, Kruit JK, Pape TD, Parks JS, Kuipers F, Hayden MR. Tissue-specific induction of intestinal ABCA1 expression with a liver X receptor agonist raises plasma HDL cholesterol levels. Circ Res 99(7):672-4. 2006. [PMID 16946132]

(05) Brunham LR, Singaraja RR, Hayden MR. Variations on a gene: rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis. Annu Rev Nutr 26:105-29. 2006. Review. [PMID 16704350]

(06) Christie BR, Li AM, Redila VA, Booth H, Wong BK, Eadie BD, Ernst C, Simpson EM. Deletion of the nuclear receptor Nr2e1 impairs synaptic plasticity and dendritic structure in the mouse dentate gyrus. Neurosci 137(3):1031-7. 2006. [PMID 16289828]

(07) Coburn B. The first characterization of homozygous HOX gene mutation in humans. Clin Genet 69:205-6. 2006. [full text]

(08) Coburn B. Transglutaminase 5 mutations result in acral peeling skin syndrome. Clin Genet 69:204-5. 2006. [full text]

(09) Dimaras H, Coburn B, Pajovic S, Gallie BL. Loss of p75 neurotrophin receptor expression accompanies malignant progression to human and murine retinoblastoma. Mol Carcinog 45(5):333-43. 2006. [PMID 16555252]

(10) Kozoriz MG, Bates DC, Bond SR, Lai CP, Moniz DM. Passing potassium with and without gap junctions. J Neurosci 26(31):8023-4. 2006. [PMID 16888836]

(11) Kozoriz MG, Kuzmiski JB, Hirasawa M, Pittman QJ. Galanin modulates neuronal and synaptic properties in the rat supraoptic nucleus in a use and state dependent manner. J Neurophysiol 96(1):154-64. 2006. [PMID 16611841]

(12) Langlois S, Yong PJ, Yong SL, Barrett I, Kalousek DK, Miny P, Exeler R, Morris K, Robinson WP. Postnatal follow-up of prenatally diagnosed trisomy 16 mosaicism. Prenat Diagn 26(6):548-58. 2006. [PMID 16683298]

(13) Noubir S, Lee JS, Reiner NE. Pleiotropic effects of phosphatidylinositol 3-kinase in monocyte cell regulation. Prog Nucleic Acid Res Mol Biol 81:51-95. 2006. [PMID 16891169]

(14) Olson AK, Eadie BD, Ernst C, Christie BR. Environmental enrichment and voluntary exercise massively increase neurogenesis in the adult hippocampus via dissociable pathways. Hippocampus 16(3):250-60. 2006. [PMID 16411242]

(15) Poburko D, Potter K, van Breemen E, Fameli N, Liao CH, Basset O, Ruegg UT, van Breemen C. Cell Calcium 40(4):359-71. 2006. [PMID 16806462]

(16) Sekirov I, Finlay BB. Human and microbe: united we stand. Nat Med 12(7):736-7. 2006. [PMID 168829917]

(17) Shih AY, Fernandes HB, Choi FY, Kozoriz MG, Liu Y, Li P, Cowan CM, Klegeris A. Policing the police: astrocytes modulate microglial activation. J Neurosci 26(15):3887-8. 2006. [PMID 16611803]

(18) Singaraja RR, Van Eck M, Bissada N, Zimetti F, Collins HL, Hildebrand RB, Hayden A, Brunham LR, Kang MH, Fruchart JC, Van Berkel TJ, Parks JS, Staels B, Rothblat GH, Fievet C, Hayden MR. Both hepatic and extrahepatic ABCA1 have discrete and essential functions in the maintenance of plasma high-density lipoprotein cholesterol levels in vivo. Circ 114(12):1301-9. 2006. [PMID 16940190]

(19) Singaraja RR, Visscher H, James ER, Chroni A, Coutinho JM, Brunham LR, Kang MH, Zannis VI, Chimini G, Hayden MR. Specific mutations in ABCA1 have discrete effects on ABCA1 function and lipid phenotypes both in vivo and in vitro. Circ Res 99(4):389-97. 2006. [PMID 16873719]

(20) Wickham ME, Lupp C, Mascarenhas M, Vazquez A, Coombes BK, Brown NF, Coburn BA, Deng W, Puente JL, Karmali MA, Finlay BB. Bacterial genetic determinants of non-O157 STEC outbreaks and hemolytic-uremic syndrome after infection. J Infect Dis 194(6):819-27. 2006. [PMID 16941350]

(21) Yong PJ, Langlois S, Dadelszen P, Robinson W. The association between preeclampsia and placental trisomy 16 mosaicism. Prenat Diagn 26(10):956-61. 2006. [PMID 16874829]

2005 | Top

(01) Brown NF, Vallance BA, Coombes BK, Valdez Y, Coburn BA, Finlay BB. Salmonella pathogenicity island 2 is expressed prior to penetrating the intestine. PLoS Pathog (3):32. 2005. [PMID 16304611]

(02) Brunham L. A common mutation in IVD associated with asymptomatic isovaleric acidemia: implications for newborn screening. Clin Genet 67:226-7. 2005. [full text]

(03) Brunham L. Common inactivating mutations in PCSK9 cause low LDL cholesterol. Clin Genet 67:476-7. 2005. [full text]

(04) Brunham LR, Singaraja RR, Pape TD, Kejariwal A, Thomas PD, Hayden MR. Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene. PLoS Genet 1(6):0739-47. [PMID 16429166]

(05) Coburn B. Osteoarthritis? Try asporin. Clin Genet 67(5):394-5. 2005. [PMID 15811005]

(06) Coburn B. Beating congenital heart defects with embryonic stem cells. Clin Genet 67(3):224-5. 2005. [full text]

(07) Coburn B, Li Y, Owen D, Vallance BA, Finlay BB. Salmonella enterica serovar Typhimurium pathogenicity island 2 is necessary for complete virulence in a mouse model of infectious enterocolitis. Infect Immun 73(6):3219-27. 2005. [PMID 15908346]

(08) Coombes BK, Coburn B, Potter AA, Gomis S, Mirakhur K, Li Y, Finlay BB. Analysis of the contribution of salmonella pathogenicity island 1 and 2 to enteric disease progression using a novel bovine ileal loop model and a murine model of infectious enterocolitis. Infect Immun 73:7181-9. 2005. [PMID 16239510]

(09) Eadie BD, Redila Va, Christie BR. Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. J Comp Neurol 486(1):39-47. 2005. [PMID 15834963]

(10) Heine HL, Leong HS, Rossi FM, McManus BM, Podor TJ. Strategies of conditional gene expression in myocardium: an overview. Methods Mol Med 112:109-54. 2005. [PMID 16010014]

(11) Rauh MJ, Ho V, Pereira C, Sham A, Sly LM, Lam V, Huxham L. SHIP represses the generation of alternatively activated macrophages. Immunity 23(4):361074. 2005. [PMID 16226502]

(12) Sendide K, Reiner NE, Lee JS, Bourgoin S, Talal A, Hmama Z. Cross-talk between CD14 and complement receptor 3 promotes phagocytosis of mycobacteria: regulation by phosphatidylinositol 3-kinase and cytohesin-1. J Immunol 174(7):4210-9. 2005. [PMID 15778383]

(13) Timmins JM, Lee JY, Boudyguina E, Kluckman KD, Brunham LR, Mulya A, Gebre AK, Coutinho JM, Colvin PL, Smith TL, Hayden MR, Maeda N, Parks JS. Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I. J Clin Invest 115(5):1333-1342. 2005. [PMID 15841208]

2004 | Top

(01) Brunham LR. The long and short of it: C-type naturietic peptide as a novel therapy for achondroplasia? Clin Genet 65(6):458-9. 2004. [full text]

(02) Brunham LR. MEF2A at the heart of coronary artery disease? Clin Genet 65(3):178-80. 2004. [full text]

(03) Coburn B. A rare disorder, ethylmalonic encephalopathy, is caused by mutations in a mitochondrial protein. Clin Genet 65(6):460-2. 2004. [full text]

(04) Coburn, BA. Pyruvate kinase deficiency: providing protection from Plasmodium parasitism. Clin Genet 65(4):264-6. 2004. [full text]

(05) Davani EY, Dorscheid DR, Lee CH, van Breemen C, Walley KR. Novel regulatory mechanism of cardiomyocyte contractility involving ICAM-1 and the cytoskeleton. Am J Physiol Heart Circ Physiol 287(3):H1013-22. 2004. [PMID 15087287]

(06) Gruenheid S, Sekirov I, Thomas NA, Deng W, O’Donnell P, Goode D, Li Y, Frey EA, Brown NF, Metainikov P, Pawson T, Ashman K, Finlay BB. Identification and characterization of N1eA, a non-LEE-encoded type III translocated virulence factor of enterohaemorrhagic Escherichia coli O157:H7. Mol Microbio 51(5):1233-49. 2004. [PMID 14982621]

(07) Guan JZ, Tamasawa N, Brunham LR, Matsui J, Murakami H, Suda T, Ochiai S, Tsutsui M, Kudou K, Satoh K, Hayden MR. A case of Tangier disease with a novel mutation in the C-terminal region of ATP-binding cassette transporter A1. Am J Med Genet 130A(4):398-401. 2004. [PMID 15384103]

(08) Hung RW, Chow AW. Dissecting the “end game”: clinical relevance, molecular mechanisms and laboratory assessment of apoptosis. Clin Invest Med 27(6):324-44. 2004. [PMID 15675113]

(09) Johnson RM, Heslop CL, Deber CM. Hydrophobic helical hairpins: design and packing interactions in membrane environments. Biochem 43(45):14361-9. 2004. [PMID 15533040]

(10) Lee JSI, Hmama Z, Mui A, Reiner NE. Stable gene silencing in human monocytic cell lines using lentiviral-delivered siRNA: silencing of the p110a isoform of phosophoinositide 3-kinase reveals differential regulation of adherence induced by 1a, 25-dihydroxycholecalciferol and bacterial lipopolysaccharide. J Biol Chem 279:9379-88. 2004. [PMID 14672955]

(11) McHardy LM, Sinotte R, Troussard A, Sheldon C, Church J, Williams DE, Andersen RJ, Dedhar S, Roberge M, Roskelley CD. The tumor invasion inhibitor dihydromotuporamine C activates RHO, remodels stress fibers and focal adhesions, and stimulates sodium-proton exchange. Cancer Res 64(4):1468-74. 2004. [PMID 14973060]

(12) Poburko D, Kuo KH, Dai J, Lee CH, van Breemen C. Organellar junctions promote targeted Ca2+ signaling in smooth muscle: why two membranes are better than one. Trends Pharmacol Sci 25(1):8-15. 2004. [PMID 14723973]

(13) Poburko D, Lee CH, van Breemen C. Vascular smooth muscle mitochondria at the cross roads of Ca(2+) regulation. Cell Calcium 35(6):509-21. 2004. [PMID 15110141]

(14) Rauh MJ, Ho V, Krystal G. SHIP is a negative regulator of M2 (alternative) macrophage programming: implications for cancer and chronic inflammation. Clin Invest Med 27(4):220-1. 2004.

(15) Rauh MJ, Sly LM, Kalesnikoff J, Hughes MR, Cao LP, Lam V, Krystal G. The role of SHIP1 in macrophage programming and activation. Biochem Soc Trans 32(5):785-8. 2004. [PMID 15494015]

(16) Sheldon C, Cheng YM, Church J. Concurrent measurements of the free cytosolic concentrations of H+ and Na+ ions with fluorescent indicators. Pflugers Arch 449(3):307-18. 2004. [PMID 15452716]

(17) Sheldon C, Church J. Reduced contribution from Na+/H+ exchange to acid extrusion during anoxia in adult rat hippocampal CA1 neurons. J Neurochem 88(3):594-603. 2004. [PMID 14720209]

(18) Sheldon C, Diarra A, Cheng YM, Church J. Sodium influx pathways during and after anoxia in rat hippocampal neurons. J Neurosci 24(49):11057-69. 2004. [PMID 15590922]

(19) Sly LM, Omeis SL, Rauh MJ, Krystal G. SHIP is essential for both endotoxin- and CpG-induced tolerance and for their cross-tolerance. Blood 104(11):3340.

(20) Sly LM, Rauh MJ, Kalesnikoff J, Song CH, Krystal G. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21(2):227-39. 2004. [PMID 15308103]

(21) Tan C, Cruet-Hennequart S, Troussard A, Fazli L, Costello P, Sutton K, Wheeler J, Gleave M, Sanghera J, Dedhar S. Regulation of tumor angiogenesis by integrin-linked kinase (ILK). Cancer Cell 5:79-90. 2004. [PMID 14749128]

(22) Zaharik ML, Cullen VL, Fung AM, Libby SJ, Kujat Choy SL, Coburn B, Kehres DG, Maguire ME, Fang FC, Finlay BB. The Salmonella enterica serovar typhimurium divalent cation transport systems MntH and SitABCD are essential for virulence in an Nramp1G169 murine typhoid model. Infect Immun 72(9):5522-5. 2004. [PMID 15322058]

2003 | Top

(01) Brunham, LR, Hayden MR. Clarity is essential when using nucleotide number systems. Atherosclerosis 170(2):349. 2003. [PMID 14612218]

(02) Brunham, L, Lee P, Pinto A. Medical students not mum on Iraq. CMAJ. 169(6):541. 2003. [full text]

(03) Kalesnikoff J, Sly LM, Hughes MR, Buchse T, Rauh MJ, Cao LP et al. The role of SHIP in cytokine-induced signaling. Rev Physiol Biochem Pharmacol 149:87-103. 2003. [PMID 12692707]

(04) Krebs C, Fernandes HB, Sheldon C, Raymond LA, Baimbridge KG. Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. J Neurosci 23:3364-72. 2003. [PMID 12716944]

(05) Kuo KH, Dai J, Seow CY, Lee CH, van Breemen C. Relationship between asynchronous Ca2+ waves and force development in intact smooth muscle bundles of the porcine trachea. Am J Physiol Lung Cell Mol Physiol 285(6):L1345-53. 2003. [PMID 12936908]

(06) Rauh MJ, Kalesnikoff J, Hughes M, Sly L, Lam V, Krystal G. Role of Src homology 2-containing-inositol 5′-phosphatase (SHIP) in mast cells and macrophages. Biochem Soc Trans 31:286-91. 2003. [PMID 12546703]

(07) Rupert JL, Monsalve MV, Kidd KK, Tan C, Hochachka PW, Devine DV. Selective pressure has not acted against hypercoagulability alleles in high-altitude Amerindians 17. Ann Hum Genet 67:426-32. 2003. [PMID 12940916]

(08) Singaraja RR, Brunham LR, Visscher H, Kastelein JJ, Hayden MR. Efflux and atherosclerosis: the clinical and biochemical impact of variations in the ABCA1 gene. Arterioscler Thromb Vasc Biol 23:1322-32. 2003. [PMID 12763760]

(09) Sly LM, Rauh MJ, Kalesnikoff J, Buchse T, Krystal G. SHIP, SHIP2, and PTEN activities are regulated in vivo by modulation of their protein levels: SHIP is up-regulated in macrophages and mast cells by lipopolysaccharide. Exp Hematol 31(12):1170-81. 2003. [PMID 14662322]

(10) Szado T, Kuo KH, Bernard-Helary K, Poburko D, Lee CH, Seow C, Ruegg UT, van Breemen C. Agonist-induced mitochondrial Ca2+ transients in smooth muscle. FASEB J 17:28-37. 2003. [PMID 12522109]

(11) Wellington CL, Brunham LR, Zhou S, Singaraja RR, Visscher H, Gelfer A et al. Alterations of plasma lipids in mice via adenoviral-mediated hepatic overexpression of human ABCA1. J Lipid Res 44:1470-80. 2003. [PMID 12730295]

(12) Yong PJ. Placentology in the world’s most livable city: HLA-G, pre-eclampsia and HIF-11. Clin Invest Med 26:10-11. 2003.

(13) Yong PJ, Barrett IJ, Kalousek DK, Robinson WP. Clinical aspects, prenatal diagnosis, and pathogenesis of trisomy 16 mosaicism. J Med Genet 40:175-82. 2003. [PMID 12624135]

(14) Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee KF, Gage FH. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci USA 100(11):6777-82. 2003. [PMID 12748381]

2002 | Top

(01) Brett CL, Kelly T, Sheldon C, Church J. Regulation of Cl-/HCO3- exchange by cMP-dependent protein kinase in actuely isolated adult rata hippocampal CA1 neurons. J Physiol 545:837-53. 2002. [PMID 12482890]

(02) Crowley CM, Lee CH, Gin SA, Keep AM, Cook RC, van Breemen C. The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein. Am J Physiol Heart Circ Physiol 283:H1271-81. 2002. [PMID 12234776]

(03) Kum WW, Hung RW, Cameron SB, Chow AW. Temporal sequence and functional implications of V beta-specific T cell receptor down-regulation and costimulatory molecule expression following in vitro stimulation with the staphylococcal superantigen Toxic shock syndrome toxin-1. J Infect Dis 185:555-60. 2002. [PMID 11865410]

(04) Lee CH, Rahimian R, Szado T, Sandhu J, Poburko D, Behra T, Chan L, van Breemen C. Sequential opening of IP(3)-sensitive Ca(2+) channels and SOC during alpha-adrenergic activation of rabbit vena cava. Am J Physiol Heart Circ Physiol 282:H1768-77. 2002. [PMID 11959642]

(05) Lee CH, Poburko D, Kuo KH, Seow CY, van Breemen C. Ca(2+) oscillations, gradients, and homeostasis in vascular smooth muscle. Am J Physiol Heart Circ Physiol 282:H1571-83. 2002. [PMID 11959618]

(06) Lee CH, Poburko D, Kuo KH, Seow C, van Breemen C. Relationship between the sarcoplasmic reticulum and the plasma membrane. Novartis Found Symp 246:26-41. 2002. [PMID 12164314]

(07) Otto SP, Yong PJ. The evolution of gene duplicates. Adv Genet 46:451-83. 2002. [PMID 11931235]

(08) Rauh MJ. The forecast is bright for budding clinician-scientists on Canada’s west coast. Clin Invest Med 25:66-7. 2002.

(09) Rauh MJ, Krystal G. Of mice and men: elucidating the role of SH2-containing inositol 5-phosphatase (SHIP) in human disease. Clin Invest Med 25:68-70. 2002.

(10) Rauh MJ. An inspiring model for translational research: nuclear factor-kappaB (NF-kappaB), bench to bedside. Clin Invest Med 25:65-6. 2002.

(11) Sheldon C, Church J. Na+/H+ exchange: molecular regulation to therapeutic development. Clin Invest Med 25:229-32. 2002.

(12) Sheldon C, Church J. Intracellular pH response to anoxia in acutely dissociated adult rat hippocampal CA1 neurons. J Neurophysiol 87:2209-24. 2002. [PMID 11976362]

(13) Takeshita S, Namba N, Zhao JJ, Jiang Y, Genant HK, Silva MJ, Brodt MD, Helgason CD, Kalesnikoff J, Rauh MJ, Humphries RK, Krystal G, Teitelbaum SL, Ross FP. SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts. Nat Med 8:943-9. 2002. [PMID 12161749]

(14) Tan C, Mui A, Dedhar S. Integrin-linked kinase regulates inducible nitric oxide synthase and cylcooxygenase-2 expression in an NF-kappa B-dependent manner. J Biol Chem 277:3109-16. 2002. [PMID 11724787]

(15) Yong PJ, Marion SA, Barrett IJ, Kalousek DK, Robinson WP. Evidence for imprinting on chromosome 16: the effect of uniparental disomy on the outcome of mosaic trisomy 16 pregnancies. Am J Med Genet 112:123-32. 2002. [PMID 12244544]

2001 | Top

(01) Coburn B Two new genes have been identified for the obesity disorder Bardet-Biedl syndrome. Clin Genet 60:176-7. 2001. [PMID 11595018]

(02) Diarra A, Sheldon C, Church J. In situ calibration and [H+] sensitivity of the fluorescent Na+ indicator SBFI. Am J Physiol Cell Physiol 280:C1623-3. 2001. [PMID 11350758]

(03) Kum WW, Cameron SB, Hung RW, Kalyan S, Chow AW. Temporal sequence and kinetics of proinflammatory and anti-inflammatory cytokine secretion induced by toxic shock syndrome toxin 1 in human peripheral blood mononuclear cells. Infect Immun 69:7544-9. 2001. [PMID 11705931]

(04) Lee CH, Poburko D, Sahota P, Sandhu J, Ruehlmann DO, van Breemen C. The mechanism of phenylephrine-mediated [Ca(2+)](i) oscillations underlying tonic contraction in the rabbit inferior vena cava. J Physiol 534:641-50. 2001. [PMID 11483697]

2000 | Top

(01) Ruehlmann DO, Lee CH, Poburko D, van Breemen C. Asynchronous Ca(2+) waves in intact venous smooth muscle. Circ Res 86:E72-9. 2000. [PMID 10700457]

(02) Wright JM, Lee CH, Chambers GK. Real-world effectiveness of anti-hypertensive drugs. (Letter to the editor). CMAJ 162: 190-1. 2000.

1999 | Top

(01) Bernard NF, Yannakis CM, Lee JS, Tsoukas CM. Human immunodeficiency virus (HIV)-specific cytotoxic T lymphocyte activity in HIV-exposed seronegative persons. J Infect Dis 179:538-47. 1999. [PMID 9952359]

(02) Diarra A, Sheldon C, Brett CL, Baimbridge KG, Church J. Anoxia-evoked intracellular pH and Ca2+ concentration changes in cultured postnatal rat hippocampal neurons. Neuroscience 93: 1003-16. 1999. [PMID 10473265]

(03) Rauh MJ, Blackmore V, Andrechek ER, Tortorice CG, Daly R, Lai VK et al. Accelerated mammary tumor development in mutant polyomavirus middle T transgenic mice expressing elevated levels of either the Shc or Grb2 adapter protein. Mol Cell Biol 19: 8169-79. 1999. [PMID 10567542]

(04) Wright JM, Lee CH, Chambers GK. Systematic review of anti-hypertensive therapies: does the evidence assist in choosing a first-line drug? CMAJ 161: 22-35. 1999. [PMID 10420860]

(05) Wright JM, Lee CH, Chambers GK. Choosing a first-line anti-hypertensive. (Letter to the editor). CMAJ 161: 1101. 1999.

1998 | Top

(01) Tang P, Sutherland CL, Gold MR, Finlay BB. Listeria monocytogenes invasion of epithelial cells requires the MEK-1/ERK-2 mitogen-activated protein kinase pathway. Infect Immun 66(3):1106-12. 1998. [PMID 9488402]

(02) Webster MA, Hutchinson JN, Rauh MJ, Muthuswamy SK, Anton M, Tortorice CG et al. Requirement for both Shc and phosphatidylinositol 3′ kinase signaling pathways in polyomavirus middle T-mediated mammary tumorigenesis. Mol Cell Biol 18: 2344-59. 1998. [PMID 9528804]

1997 | Top

(01) Appanna VD, Rauh MJ, Hamel R, Gauthier E. Isolation and characterization of an aluminum sensitive mutant of Pseudomonas fluorescens. FEMS Microbiol Letts. 1997.

(02) Hung RW, Chow AW. Apoptosis – molecular mechanisms, regulation, and role in pathogenesis. Can J Infect Dis. 1997.

1996 | Top

(01) Richter AM, Yip S, Meadows H, Jain AK, Neyndorff H, Moreno G, Salet C, Levy JG. Photosensitizing potencies of the structural analogues of benzoporphyrin derivative in different biological test systems. J Clin Laser Med Surg 14(5):335-41. 1996. [PMID 9612201]

(02) Tang P, Rosenshine I, Cossart P, Finlay BB. Listeriolysin O activates mitogen-activated protein kinase in eucaryotic cells. Infect Immun 64:2359-61. 1996. [PMID 8675352]

1995 | Top

(01) Levy JG, Dowding C, Mitchell D, Sorrenti R, Yip S, Jamieson C. Selective elimination of malignant stem cells using photosensitizers followed by light treatment. Stem Cells 13(4):336-43. 1995. [PMID 7549891]

1994 | Top

(01) Tang P, Rosenshine I, Finlay BB. Listeria monocytogenes, an invasive bacterium, stimulates MAP kinase upon attachment to epithelial cells. Mol Biol Cell 5:455-64. 1994. [PMID 8054686]

1993 | Top

(01) Leitch HA, Yip ST, Jamieson CH, Levy JG. Inhibition of murine hematopoiesis by CAMAL, an inhibitor of human hematopoiesis. Leukemia 7:717-24. 1993. [PMID 8483324]

(02) Mohamedali Z, Auersperg N. A simple method to produce quantifiable cell suspensions from fixed, stained monolayers grown in culture. In Vitro Cell Dev 29A:685-7. 1993.

(03) Mohamedali Z, Auersperg N. Immortalization reduces the capacity of normal cells to inhibit the transformation of their Ha-ras-oncogene infected neighbors in coculture. Am Assoc Can Res 34:177. 1993.

(04) Mohamedali Z, Auersperg N. Quantifiable cell suspensions from fixed, stained monolayers grown in culture. In Vitro Cell Dev Biol Anim 29A(9):685-7. 1993. [PMID 7691790]

(05) Tang P, Foubister V, Pucciarella MG, Finlay BB. Methods to study bacterial invasion. J Micro Methods 18(3): 227-40. 1993.

1992 | Top

(01) Mohamedali Z, Auersperg N. Inhibition of early transformation events by low passage cells exceeds inhibition by immortalized cells. Proc Can Fed Biol Soc 35:69. 1992.

1991 | Top

(01) Richter AM, Yip S, Waterfield E, Logan PM, Slonecker CE, Levy JG. Mouse skin photosensitization with benzoporphyrin derivatives and Photofrin: macroscopic and microscopic evaluation. Photochem Photobiol 53:281-6. 1991. [PMID 1826372]

(02) Mohamedali Z, Auersperg N. Cell interactions in the regulation of transformation. In Vitro Cell Dev 27:130A. 1991.